Targeting a c-MYC G-quadruplex DNA with a fragment library
We report here on the screening of a fragment library against a G-quadruplex element in the human c-MYC promoter. The ten fragment hits had significant concordance between a biophysical assay, in silico modelling and c-MYC expression inhibition, highlighting the feasibility of applying a fragment-ba...
Gespeichert in:
| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2014-01, Vol.50 (14), p.1704-1707 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1707 |
|---|---|
| container_issue | 14 |
| container_start_page | 1704 |
| container_title | Chemical communications (Cambridge, England) |
| container_volume | 50 |
| creator | Nasiri, Hamid R Bell, Neil M McLuckie, Keith I E Husby, Jarmila Abell, Chris Neidle, Stephen Balasubramanian, Shankar |
| description | We report here on the screening of a fragment library against a G-quadruplex element in the human c-MYC promoter. The ten fragment hits had significant concordance between a biophysical assay, in silico modelling and c-MYC expression inhibition, highlighting the feasibility of applying a fragment-based approach to the targeting of a quadruplex nucleic acid. |
| doi_str_mv | 10.1039/c3cc48390h |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1505330460</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1492671928</sourcerecordid><originalsourceid>FETCH-LOGICAL-c361t-b767ac8568f5e00be85caf5fa4ae249d0bb405964e40f1b9154ff0c2fabb00ea3</originalsourceid><addsrcrecordid>eNqFkE1LAzEQhoMotlYv_gDZowjRyeZjE2-yaitUvVTQ05KkSbuy249kF_Xfu7XVq3OZgffhhXkQOiVwSYCqK0utZZIqmO-hPqGCYc7k6_7m5gpnlPEeOorxHbohXB6iXsqoYlymfXQ90WHmmnIxS3Ri8eNbngzxutXT0K4q95ncPt0kH2Uz71If9Kx2iyapShN0-DpGB15X0Z3s9gC93N9N8hEePw8f8psxtlSQBptMZNpKLqTnDsA4ya323GumXcrUFIxhwJVgjoEnRhHOvAebem0MgNN0gM63vauwXLcuNkVdRuuqSi_cso0F4cApBSbgf5SpVGREpbJDL7aoDcsYg_PFKpR191ZBoNhoLXKa5z9aRx18tuttTe2mf-ivR_oNx7hwqQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1492671928</pqid></control><display><type>article</type><title>Targeting a c-MYC G-quadruplex DNA with a fragment library</title><source>MEDLINE</source><source>Royal Society Of Chemistry Journals 2008-</source><source>Alma/SFX Local Collection</source><creator>Nasiri, Hamid R ; Bell, Neil M ; McLuckie, Keith I E ; Husby, Jarmila ; Abell, Chris ; Neidle, Stephen ; Balasubramanian, Shankar</creator><creatorcontrib>Nasiri, Hamid R ; Bell, Neil M ; McLuckie, Keith I E ; Husby, Jarmila ; Abell, Chris ; Neidle, Stephen ; Balasubramanian, Shankar</creatorcontrib><description>We report here on the screening of a fragment library against a G-quadruplex element in the human c-MYC promoter. The ten fragment hits had significant concordance between a biophysical assay, in silico modelling and c-MYC expression inhibition, highlighting the feasibility of applying a fragment-based approach to the targeting of a quadruplex nucleic acid.</description><identifier>ISSN: 1359-7345</identifier><identifier>EISSN: 1364-548X</identifier><identifier>DOI: 10.1039/c3cc48390h</identifier><identifier>PMID: 24394582</identifier><language>eng</language><publisher>England</publisher><subject>Computer Simulation ; G-Quadruplexes ; Humans ; Models, Molecular ; Promoter Regions, Genetic - genetics ; Proto-Oncogene Proteins c-myc - genetics</subject><ispartof>Chemical communications (Cambridge, England), 2014-01, Vol.50 (14), p.1704-1707</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c361t-b767ac8568f5e00be85caf5fa4ae249d0bb405964e40f1b9154ff0c2fabb00ea3</citedby><cites>FETCH-LOGICAL-c361t-b767ac8568f5e00be85caf5fa4ae249d0bb405964e40f1b9154ff0c2fabb00ea3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24394582$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nasiri, Hamid R</creatorcontrib><creatorcontrib>Bell, Neil M</creatorcontrib><creatorcontrib>McLuckie, Keith I E</creatorcontrib><creatorcontrib>Husby, Jarmila</creatorcontrib><creatorcontrib>Abell, Chris</creatorcontrib><creatorcontrib>Neidle, Stephen</creatorcontrib><creatorcontrib>Balasubramanian, Shankar</creatorcontrib><title>Targeting a c-MYC G-quadruplex DNA with a fragment library</title><title>Chemical communications (Cambridge, England)</title><addtitle>Chem Commun (Camb)</addtitle><description>We report here on the screening of a fragment library against a G-quadruplex element in the human c-MYC promoter. The ten fragment hits had significant concordance between a biophysical assay, in silico modelling and c-MYC expression inhibition, highlighting the feasibility of applying a fragment-based approach to the targeting of a quadruplex nucleic acid.</description><subject>Computer Simulation</subject><subject>G-Quadruplexes</subject><subject>Humans</subject><subject>Models, Molecular</subject><subject>Promoter Regions, Genetic - genetics</subject><subject>Proto-Oncogene Proteins c-myc - genetics</subject><issn>1359-7345</issn><issn>1364-548X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LAzEQhoMotlYv_gDZowjRyeZjE2-yaitUvVTQ05KkSbuy249kF_Xfu7XVq3OZgffhhXkQOiVwSYCqK0utZZIqmO-hPqGCYc7k6_7m5gpnlPEeOorxHbohXB6iXsqoYlymfXQ90WHmmnIxS3Ri8eNbngzxutXT0K4q95ncPt0kH2Uz71If9Kx2iyapShN0-DpGB15X0Z3s9gC93N9N8hEePw8f8psxtlSQBptMZNpKLqTnDsA4ya323GumXcrUFIxhwJVgjoEnRhHOvAebem0MgNN0gM63vauwXLcuNkVdRuuqSi_cso0F4cApBSbgf5SpVGREpbJDL7aoDcsYg_PFKpR191ZBoNhoLXKa5z9aRx18tuttTe2mf-ivR_oNx7hwqQ</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Nasiri, Hamid R</creator><creator>Bell, Neil M</creator><creator>McLuckie, Keith I E</creator><creator>Husby, Jarmila</creator><creator>Abell, Chris</creator><creator>Neidle, Stephen</creator><creator>Balasubramanian, Shankar</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TM</scope></search><sort><creationdate>20140101</creationdate><title>Targeting a c-MYC G-quadruplex DNA with a fragment library</title><author>Nasiri, Hamid R ; Bell, Neil M ; McLuckie, Keith I E ; Husby, Jarmila ; Abell, Chris ; Neidle, Stephen ; Balasubramanian, Shankar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c361t-b767ac8568f5e00be85caf5fa4ae249d0bb405964e40f1b9154ff0c2fabb00ea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Computer Simulation</topic><topic>G-Quadruplexes</topic><topic>Humans</topic><topic>Models, Molecular</topic><topic>Promoter Regions, Genetic - genetics</topic><topic>Proto-Oncogene Proteins c-myc - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nasiri, Hamid R</creatorcontrib><creatorcontrib>Bell, Neil M</creatorcontrib><creatorcontrib>McLuckie, Keith I E</creatorcontrib><creatorcontrib>Husby, Jarmila</creatorcontrib><creatorcontrib>Abell, Chris</creatorcontrib><creatorcontrib>Neidle, Stephen</creatorcontrib><creatorcontrib>Balasubramanian, Shankar</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Nucleic Acids Abstracts</collection><jtitle>Chemical communications (Cambridge, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nasiri, Hamid R</au><au>Bell, Neil M</au><au>McLuckie, Keith I E</au><au>Husby, Jarmila</au><au>Abell, Chris</au><au>Neidle, Stephen</au><au>Balasubramanian, Shankar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Targeting a c-MYC G-quadruplex DNA with a fragment library</atitle><jtitle>Chemical communications (Cambridge, England)</jtitle><addtitle>Chem Commun (Camb)</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>50</volume><issue>14</issue><spage>1704</spage><epage>1707</epage><pages>1704-1707</pages><issn>1359-7345</issn><eissn>1364-548X</eissn><abstract>We report here on the screening of a fragment library against a G-quadruplex element in the human c-MYC promoter. The ten fragment hits had significant concordance between a biophysical assay, in silico modelling and c-MYC expression inhibition, highlighting the feasibility of applying a fragment-based approach to the targeting of a quadruplex nucleic acid.</abstract><cop>England</cop><pmid>24394582</pmid><doi>10.1039/c3cc48390h</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1359-7345 |
| ispartof | Chemical communications (Cambridge, England), 2014-01, Vol.50 (14), p.1704-1707 |
| issn | 1359-7345 1364-548X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1505330460 |
| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Computer Simulation G-Quadruplexes Humans Models, Molecular Promoter Regions, Genetic - genetics Proto-Oncogene Proteins c-myc - genetics |
| title | Targeting a c-MYC G-quadruplex DNA with a fragment library |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-12T20%3A05%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Targeting%20a%20c-MYC%20G-quadruplex%20DNA%20with%20a%20fragment%20library&rft.jtitle=Chemical%20communications%20(Cambridge,%20England)&rft.au=Nasiri,%20Hamid%20R&rft.date=2014-01-01&rft.volume=50&rft.issue=14&rft.spage=1704&rft.epage=1707&rft.pages=1704-1707&rft.issn=1359-7345&rft.eissn=1364-548X&rft_id=info:doi/10.1039/c3cc48390h&rft_dat=%3Cproquest_cross%3E1492671928%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1492671928&rft_id=info:pmid/24394582&rfr_iscdi=true |