Analysis of human ITPase nucleobase specificity by site-directed mutagenesis

Inosine triphosphate (ITP) pyrophosphohydrolase, or ITPase, is an intracellular enzyme that is responsible for the hydrolysis of the acidic anhydride bond between the alpha and beta phosphates in ITP, and other noncanonical nucleoside triphosphates, producing the corresponding nucleoside monophospha...

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Veröffentlicht in:	Biochimie 2013-09, Vol.95 (9), p.1711-1721
Hauptverfasser:	Gall, Amanda D., Gall, Anthony, Moore, Ashley C., Aune, Martin K., Heid, Steven, Mori, Ayaka, Burgis, Nicholas E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - analogs & derivatives Adenine - toxicity Conserved Sequence Escherichia coli Escherichia coli - drug effects Escherichia coli - genetics Hepatitis C Humans Hypoxanthine Inosine Triphosphatase ITPA Mutagenesis, Site-Directed Mutation Nucleotides - metabolism Purine metabolism Pyrophosphatases - chemistry Pyrophosphatases - genetics Pyrophosphatases - isolation & purification Pyrophosphatases - metabolism Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - isolation & purification Recombinant Proteins - metabolism Substrate Specificity Thiopurine toxicity
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