Cycloartenyl trans-ferulate, a component of the bran byproduct of sake-brewing rice, inhibits mammalian DNA polymerase and suppresses inflammation

•Cycloartenyl trans-ferulate (CAF) was isolated from sake-brewing rice bran.•CAF inhibited the activity of mammalian DNA polymerases of A-, B-, and X-families.•The components of CAF, cycloartenol, and ferulic acid, had no inhibitory activity.•CAF had anti-inflammatory properties, unlike cycloartenol...

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Veröffentlicht in:	Food chemistry 2013-11, Vol.141 (2), p.1000-1007
Hauptverfasser:	Mizushina, Yoshiyuki, Kuriyama, Isoko, Yamazaki, Asahi, Akashi, Takahiro, Yoshida, Hiromi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-inflammation Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - isolation & purification Anti-Inflammatory Agents - pharmacology Biological and medical sciences Cattle Coumaric Acids - chemistry Coumaric Acids - isolation & purification Coumaric Acids - pharmacology Cycloartenyl trans-ferulate DNA polymerase DNA-Directed DNA Polymerase - analysis DNA-Directed DNA Polymerase - genetics DNA-Directed DNA Polymerase - metabolism Enzyme inhibitor Enzyme Inhibitors - chemistry Enzyme Inhibitors - isolation & purification Enzyme Inhibitors - pharmacology Female Food toxicology Humans Inflammation - drug therapy Inflammation - immunology Medical sciences Mice Mice, Inbred ICR Nucleic Acid Synthesis Inhibitors Oryza - chemistry Oryza sativa Plant Extracts - chemistry Plant Extracts - isolation & purification Plant Extracts - pharmacology Rats Sake-brewing rice bran Seeds - chemistry Toxicology Vitaceae Waste Products - analysis Wine - analysis
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