Bioaccumulation of butyltins and liver damage in the demersal fish Cathorops spixii (Siluriformes, Ariidae)
The toxicity of butyltin compounds (BTs), mainly tributyltin (TBT), has been reported in different organisms. However, such an analysis in fish after field exposure with reference to the related biomarkers has not been commonly observed in the literature. This study presents the uptake of BTs in the...
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| Veröffentlicht in: | Environmental science and pollution research international 2014-02, Vol.21 (4), p.3166-3174 |
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| creator | dos Santos, Dayana Moscardi Santos, Gustavo Souza Cestari, Marta Margarete de Oliveira Ribeiro, Ciro Alberto de Assis, Helena Cristina Silva Yamamoto, Flavia Guiloski, Izonete Cristina de Marchi, Mary Rosa Rodrigues Montone, Rosalinda Carmela |
| description | The toxicity of butyltin compounds (BTs), mainly tributyltin (TBT), has been reported in different organisms. However, such an analysis in fish after field exposure with reference to the related biomarkers has not been commonly observed in the literature. This study presents the uptake of BTs in the liver of a neotropical marine catfish Cathorops spixii in Paranagua Bay, an important estuarine system located in southern Brazil. Two different areas, close to and distant from the harbor, were used for chemical analysis evaluation of hepatotoxicity through genetic, enzymatic, and histopathological biomarkers. The presence of polycyclic aromatic hydrocarbons in bile was also considered as a biomarker. The results showed a significant relationship between TBT levels and the inhibition of biotransformation enzymes and high occurrence of melanomacrophages in fish collected close to the harbor site. These effects were linked to the absence of TBT metabolites in the liver. In the second site, the presence of DBT was associated with an increase in EROD and GST activity. The larger amount of DNA damage as well as the highest oxidative stress was noted in fish from the less TBT-polluted area, where DBT and bile PAHs occurred. These findings showed different impact levels due to or increased by the chronic exposure of biota to BTs. |
| doi_str_mv | 10.1007/s11356-013-2280-y |
| format | Article |
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However, such an analysis in fish after field exposure with reference to the related biomarkers has not been commonly observed in the literature. This study presents the uptake of BTs in the liver of a neotropical marine catfish Cathorops spixii in Paranagua Bay, an important estuarine system located in southern Brazil. Two different areas, close to and distant from the harbor, were used for chemical analysis evaluation of hepatotoxicity through genetic, enzymatic, and histopathological biomarkers. The presence of polycyclic aromatic hydrocarbons in bile was also considered as a biomarker. The results showed a significant relationship between TBT levels and the inhibition of biotransformation enzymes and high occurrence of melanomacrophages in fish collected close to the harbor site. These effects were linked to the absence of TBT metabolites in the liver. In the second site, the presence of DBT was associated with an increase in EROD and GST activity. The larger amount of DNA damage as well as the highest oxidative stress was noted in fish from the less TBT-polluted area, where DBT and bile PAHs occurred. 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However, such an analysis in fish after field exposure with reference to the related biomarkers has not been commonly observed in the literature. This study presents the uptake of BTs in the liver of a neotropical marine catfish Cathorops spixii in Paranagua Bay, an important estuarine system located in southern Brazil. Two different areas, close to and distant from the harbor, were used for chemical analysis evaluation of hepatotoxicity through genetic, enzymatic, and histopathological biomarkers. The presence of polycyclic aromatic hydrocarbons in bile was also considered as a biomarker. The results showed a significant relationship between TBT levels and the inhibition of biotransformation enzymes and high occurrence of melanomacrophages in fish collected close to the harbor site. These effects were linked to the absence of TBT metabolites in the liver. In the second site, the presence of DBT was associated with an increase in EROD and GST activity. The larger amount of DNA damage as well as the highest oxidative stress was noted in fish from the less TBT-polluted area, where DBT and bile PAHs occurred. These findings showed different impact levels due to or increased by the chronic exposure of biota to BTs.</description><subject>Analytical chemistry</subject><subject>Animals</subject><subject>Antifouling substances</subject><subject>Aquatic Pollution</subject><subject>Ariidae</subject><subject>Atmospheric Protection/Air Quality Control/Air Pollution</subject><subject>Bile</subject><subject>Bile - chemistry</subject><subject>Bioaccumulation</subject><subject>Biomarkers</subject><subject>Biota</subject><subject>Biotransformation</subject><subject>Brazil</subject><subject>Butyltin</subject><subject>Catfish</subject><subject>Catfishes - metabolism</subject><subject>Cathorops spixii</subject><subject>Chemical analysis</subject><subject>Chronic exposure</subject><subject>Cytochrome P-450 CYP1A1 - metabolism</subject><subject>demersal fish</subject><subject>DNA Damage</subject><subject>Earth and Environmental 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However, such an analysis in fish after field exposure with reference to the related biomarkers has not been commonly observed in the literature. This study presents the uptake of BTs in the liver of a neotropical marine catfish Cathorops spixii in Paranagua Bay, an important estuarine system located in southern Brazil. Two different areas, close to and distant from the harbor, were used for chemical analysis evaluation of hepatotoxicity through genetic, enzymatic, and histopathological biomarkers. The presence of polycyclic aromatic hydrocarbons in bile was also considered as a biomarker. The results showed a significant relationship between TBT levels and the inhibition of biotransformation enzymes and high occurrence of melanomacrophages in fish collected close to the harbor site. These effects were linked to the absence of TBT metabolites in the liver. In the second site, the presence of DBT was associated with an increase in EROD and GST activity. 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| fulltext | fulltext |
| identifier | ISSN: 0944-1344 |
| ispartof | Environmental science and pollution research international, 2014-02, Vol.21 (4), p.3166-3174 |
| issn | 0944-1344 1614-7499 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1505327888 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Analytical chemistry Animals Antifouling substances Aquatic Pollution Ariidae Atmospheric Protection/Air Quality Control/Air Pollution Bile Bile - chemistry Bioaccumulation Biomarkers Biota Biotransformation Brazil Butyltin Catfish Catfishes - metabolism Cathorops spixii Chemical analysis Chronic exposure Cytochrome P-450 CYP1A1 - metabolism demersal fish DNA Damage Earth and Environmental Science Ecotoxicology Environment Environmental Chemistry Environmental Health Enzymes Estuaries Genetic analysis Glutathione Transferase - metabolism Harbors Hepatotoxicity histopathology Indicator organisms Liver Liver - drug effects Liver - enzymology Liver - pathology Metabolites Neotropics Organic contaminants Oxidative stress Polycyclic aromatic hydrocarbons Polycyclic Aromatic Hydrocarbons - metabolism Research Article Siluriformes Studies Toxicity Trialkyltin Compounds - metabolism Trialkyltin Compounds - toxicity Tributyltin Waste Water Technology Water Management Water Pollutants, Chemical - metabolism Water Pollutants, Chemical - toxicity Water pollution Water Pollution Control |
| title | Bioaccumulation of butyltins and liver damage in the demersal fish Cathorops spixii (Siluriformes, Ariidae) |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-21T00%3A46%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Bioaccumulation%20of%20butyltins%20and%20liver%20damage%20in%20the%20demersal%20fish%20Cathorops%20spixii%20(Siluriformes,%20Ariidae)&rft.jtitle=Environmental%20science%20and%20pollution%20research%20international&rft.au=dos%20Santos,%20Dayana%20Moscardi&rft.date=2014-02-01&rft.volume=21&rft.issue=4&rft.spage=3166&rft.epage=3174&rft.pages=3166-3174&rft.issn=0944-1344&rft.eissn=1614-7499&rft_id=info:doi/10.1007/s11356-013-2280-y&rft_dat=%3Cproquest_cross%3E3153555103%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1504828987&rft_id=info:pmid/24217970&rfr_iscdi=true |