Double‐blind, randomized, phase 2 trial of maintenance sunitinib versus placebo after response to chemotherapy in patients with advanced urothelial carcinoma

BACKGROUND Angiogenesis contributes to the progression of urothelial carcinoma (UC). In the current study, the authors investigated the role of maintenance sunitinib in patients with advanced UC. METHODS Patients with locally recurrent/metastatic UC and adequate organ function who achieved stable di...

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Veröffentlicht in:	Cancer 2014-03, Vol.120 (5), p.692-701
Hauptverfasser:	Grivas, Petros D., Daignault, Stephanie, Tagawa, Scott T., Nanus, David M., Stadler, Walter M., Dreicer, Robert, Kohli, Manish, Petrylak, Daniel P., Vaughn, David J., Bylow, Kathryn A., Wong, Steven G., Sottnik, Joseph L., Keller, Evan T., Al‐Hawary, Mahmoud, Smith, David C., Hussain, Maha
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged angiogenesis Angiogenesis Inhibitors - administration & dosage Angiogenesis Inhibitors - therapeutic use Antineoplastic Agents - therapeutic use Biological and medical sciences bladder cancer Carcinoma, Transitional Cell - drug therapy chemotherapy Confounding Factors (Epidemiology) Disease Progression Disease-Free Survival Double-Blind Method Drug Administration Schedule Early Termination of Clinical Trials Female Humans Indoles - administration & dosage Indoles - therapeutic use Kaplan-Meier Estimate maintenance therapy Male Medical sciences Middle Aged Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Nephrology. Urinary tract diseases Pyrroles - administration & dosage Pyrroles - therapeutic use Sample Size sunitinib Treatment Outcome Tumors Tumors of the urinary system Urinary tract. Prostate gland Urologic Neoplasms - drug therapy urothelial carcinoma Vascular Endothelial Growth Factor A - blood Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors Vascular Endothelial Growth Factor Receptor-2 - blood
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