Persistent anterograde amnesia following limbic encephalitis associated with antibodies to the voltage-gated potassium channel complex
Objective Limbic encephalitis (LE) associated with antibodies to the voltage-gated potassium channel complex (VGKC) is a potentially reversible cause of cognitive impairment. Despite the prominence of cognitive dysfunction in this syndrome, little is known about patients’ neuropsychological profile...
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| Veröffentlicht in: | Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 2014-04, Vol.85 (4), p.387-391 |
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| container_title | Journal of neurology, neurosurgery and psychiatry |
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| creator | Butler, Christopher R Miller, Thomas D Kaur, Manveer S Baker, Ian W Boothroyd, Georgie D Illman, Nathan A Rosenthal, Clive R Vincent, Angela Buckley, Camilla J |
| description | Objective Limbic encephalitis (LE) associated with antibodies to the voltage-gated potassium channel complex (VGKC) is a potentially reversible cause of cognitive impairment. Despite the prominence of cognitive dysfunction in this syndrome, little is known about patients’ neuropsychological profile at presentation or their long-term cognitive outcome. Methods We used a comprehensive neuropsychological test battery to evaluate cognitive function longitudinally in 19 patients with VGKC-LE. Results Before immunotherapy, the group had significant impairment of memory, processing speed and executive function, whereas language and perceptual organisation were intact. At follow-up, cognitive impairment was restricted to the memory domain, with processing speed and executive function having returned to the normal range. Residual memory function was predicted by the antibody titre at presentation. Conclusions The results show that, despite broad cognitive dysfunction in the acute phase, patients with VGKC-LE often make a substantial recovery with immunotherapy but may be left with permanent anterograde amnesia. |
| doi_str_mv | 10.1136/jnnp-2013-306724 |
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Despite the prominence of cognitive dysfunction in this syndrome, little is known about patients’ neuropsychological profile at presentation or their long-term cognitive outcome. Methods We used a comprehensive neuropsychological test battery to evaluate cognitive function longitudinally in 19 patients with VGKC-LE. Results Before immunotherapy, the group had significant impairment of memory, processing speed and executive function, whereas language and perceptual organisation were intact. At follow-up, cognitive impairment was restricted to the memory domain, with processing speed and executive function having returned to the normal range. Residual memory function was predicted by the antibody titre at presentation. Conclusions The results show that, despite broad cognitive dysfunction in the acute phase, patients with VGKC-LE often make a substantial recovery with immunotherapy but may be left with permanent anterograde amnesia.</description><identifier>ISSN: 0022-3050</identifier><identifier>EISSN: 1468-330X</identifier><identifier>DOI: 10.1136/jnnp-2013-306724</identifier><identifier>PMID: 24403282</identifier><identifier>CODEN: JNNPAU</identifier><language>eng</language><publisher>England: BMJ Publishing Group LTD</publisher><subject>Amnesia, Anterograde - blood ; Amnesia, Anterograde - complications ; Amnesia, Anterograde - immunology ; Amnesia, Anterograde - psychology ; Antibodies - blood ; Cognitive ability ; Female ; Humans ; Immunoglobulins ; Immunotherapy ; Limbic Encephalitis - blood ; Limbic Encephalitis - complications ; Limbic Encephalitis - immunology ; Limbic Encephalitis - psychology ; Male ; Memory ; Middle Aged ; Neuropsychological Tests ; Patients ; Potassium Channels, Voltage-Gated - immunology ; Studies ; Variables</subject><ispartof>Journal of neurology, neurosurgery and psychiatry, 2014-04, Vol.85 (4), p.387-391</ispartof><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><rights>Copyright: 2014 Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b363t-bb01a54e81d2bd3e14c45a06b3a0922b0c477da237b39f34a97dc20d7f2406a73</citedby><cites>FETCH-LOGICAL-b363t-bb01a54e81d2bd3e14c45a06b3a0922b0c477da237b39f34a97dc20d7f2406a73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://jnnp.bmj.com/content/85/4/387.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttps://jnnp.bmj.com/content/85/4/387.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,314,776,780,3183,23550,27901,27902,77569,77600</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24403282$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Butler, Christopher R</creatorcontrib><creatorcontrib>Miller, Thomas D</creatorcontrib><creatorcontrib>Kaur, Manveer S</creatorcontrib><creatorcontrib>Baker, Ian W</creatorcontrib><creatorcontrib>Boothroyd, Georgie D</creatorcontrib><creatorcontrib>Illman, Nathan A</creatorcontrib><creatorcontrib>Rosenthal, Clive R</creatorcontrib><creatorcontrib>Vincent, Angela</creatorcontrib><creatorcontrib>Buckley, Camilla J</creatorcontrib><title>Persistent anterograde amnesia following limbic encephalitis associated with antibodies to the voltage-gated potassium channel complex</title><title>Journal of neurology, neurosurgery and psychiatry</title><addtitle>J Neurol Neurosurg Psychiatry</addtitle><description>Objective Limbic encephalitis (LE) associated with antibodies to the voltage-gated potassium channel complex (VGKC) is a potentially reversible cause of cognitive impairment. Despite the prominence of cognitive dysfunction in this syndrome, little is known about patients’ neuropsychological profile at presentation or their long-term cognitive outcome. Methods We used a comprehensive neuropsychological test battery to evaluate cognitive function longitudinally in 19 patients with VGKC-LE. Results Before immunotherapy, the group had significant impairment of memory, processing speed and executive function, whereas language and perceptual organisation were intact. At follow-up, cognitive impairment was restricted to the memory domain, with processing speed and executive function having returned to the normal range. Residual memory function was predicted by the antibody titre at presentation. Conclusions The results show that, despite broad cognitive dysfunction in the acute phase, patients with VGKC-LE often make a substantial recovery with immunotherapy but may be left with permanent anterograde amnesia.</description><subject>Amnesia, Anterograde - blood</subject><subject>Amnesia, Anterograde - complications</subject><subject>Amnesia, Anterograde - immunology</subject><subject>Amnesia, Anterograde - psychology</subject><subject>Antibodies - blood</subject><subject>Cognitive ability</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoglobulins</subject><subject>Immunotherapy</subject><subject>Limbic Encephalitis - blood</subject><subject>Limbic Encephalitis - complications</subject><subject>Limbic Encephalitis - immunology</subject><subject>Limbic Encephalitis - psychology</subject><subject>Male</subject><subject>Memory</subject><subject>Middle Aged</subject><subject>Neuropsychological Tests</subject><subject>Patients</subject><subject>Potassium Channels, Voltage-Gated - immunology</subject><subject>Studies</subject><subject>Variables</subject><issn>0022-3050</issn><issn>1468-330X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkUuLFTEQRoMoznV070oCbgRpzatfSxl8wcC4UHAXKkn1vbmkk7aTdmb-gL_bbu_ows3UphZ1vo-CQ8hzzt5wLpu3xxinSjAuK8maVqgHZMdV01VSsu8PyY4xIdZLzc7Ik5yPbJuuf0zOhFJMik7syK8vOGefC8ZCIRac034GhxTGiNkDHVII6drHPQ1-NN5SjBanAwRffKaQc7IeCjp67ctha_AmOY-ZlkTLAenPFArssdr_gaZU1ohfRmoPECMGatM4Bbx5Sh4NEDI-u9vn5NuH918vPlWXVx8_X7y7rIxsZKmMYRxqhR13wjiJXFlVA2uMBNYLYZhVbetAyNbIfpAK-tZZwVw7CMUaaOU5eXXqneb0Y8Fc9OizxRAgYlqy5jWrRV2LTq7oy__QY1rmuH6nedtxofqmqVeKnSg7p5xnHPQ0-xHmW82Z3hzpzZHeHOmTozXy4q54MSO6f4G_Ulbg9Qkw4_H-ut8KbJ2W</recordid><startdate>20140401</startdate><enddate>20140401</enddate><creator>Butler, Christopher R</creator><creator>Miller, Thomas D</creator><creator>Kaur, Manveer S</creator><creator>Baker, Ian W</creator><creator>Boothroyd, Georgie D</creator><creator>Illman, Nathan A</creator><creator>Rosenthal, Clive R</creator><creator>Vincent, Angela</creator><creator>Buckley, Camilla J</creator><general>BMJ Publishing Group LTD</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2P</scope><scope>NAPCQ</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20140401</creationdate><title>Persistent anterograde amnesia following limbic encephalitis associated with antibodies to the voltage-gated potassium channel complex</title><author>Butler, Christopher R ; Miller, Thomas D ; Kaur, Manveer S ; Baker, Ian W ; Boothroyd, Georgie D ; Illman, Nathan A ; Rosenthal, Clive R ; Vincent, Angela ; Buckley, Camilla J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b363t-bb01a54e81d2bd3e14c45a06b3a0922b0c477da237b39f34a97dc20d7f2406a73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Amnesia, Anterograde - blood</topic><topic>Amnesia, Anterograde - complications</topic><topic>Amnesia, Anterograde - immunology</topic><topic>Amnesia, Anterograde - psychology</topic><topic>Antibodies - blood</topic><topic>Cognitive ability</topic><topic>Female</topic><topic>Humans</topic><topic>Immunoglobulins</topic><topic>Immunotherapy</topic><topic>Limbic Encephalitis - blood</topic><topic>Limbic Encephalitis - complications</topic><topic>Limbic Encephalitis - immunology</topic><topic>Limbic Encephalitis - psychology</topic><topic>Male</topic><topic>Memory</topic><topic>Middle Aged</topic><topic>Neuropsychological Tests</topic><topic>Patients</topic><topic>Potassium Channels, Voltage-Gated - immunology</topic><topic>Studies</topic><topic>Variables</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Butler, Christopher R</creatorcontrib><creatorcontrib>Miller, Thomas D</creatorcontrib><creatorcontrib>Kaur, Manveer S</creatorcontrib><creatorcontrib>Baker, Ian W</creatorcontrib><creatorcontrib>Boothroyd, Georgie D</creatorcontrib><creatorcontrib>Illman, Nathan A</creatorcontrib><creatorcontrib>Rosenthal, Clive R</creatorcontrib><creatorcontrib>Vincent, Angela</creatorcontrib><creatorcontrib>Buckley, Camilla J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neurology, neurosurgery and psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Butler, Christopher R</au><au>Miller, Thomas D</au><au>Kaur, Manveer S</au><au>Baker, Ian W</au><au>Boothroyd, Georgie D</au><au>Illman, Nathan A</au><au>Rosenthal, Clive R</au><au>Vincent, Angela</au><au>Buckley, Camilla J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Persistent anterograde amnesia following limbic encephalitis associated with antibodies to the voltage-gated potassium channel complex</atitle><jtitle>Journal of neurology, neurosurgery and psychiatry</jtitle><addtitle>J Neurol Neurosurg Psychiatry</addtitle><date>2014-04-01</date><risdate>2014</risdate><volume>85</volume><issue>4</issue><spage>387</spage><epage>391</epage><pages>387-391</pages><issn>0022-3050</issn><eissn>1468-330X</eissn><coden>JNNPAU</coden><abstract>Objective Limbic encephalitis (LE) associated with antibodies to the voltage-gated potassium channel complex (VGKC) is a potentially reversible cause of cognitive impairment. Despite the prominence of cognitive dysfunction in this syndrome, little is known about patients’ neuropsychological profile at presentation or their long-term cognitive outcome. Methods We used a comprehensive neuropsychological test battery to evaluate cognitive function longitudinally in 19 patients with VGKC-LE. Results Before immunotherapy, the group had significant impairment of memory, processing speed and executive function, whereas language and perceptual organisation were intact. At follow-up, cognitive impairment was restricted to the memory domain, with processing speed and executive function having returned to the normal range. Residual memory function was predicted by the antibody titre at presentation. Conclusions The results show that, despite broad cognitive dysfunction in the acute phase, patients with VGKC-LE often make a substantial recovery with immunotherapy but may be left with permanent anterograde amnesia.</abstract><cop>England</cop><pub>BMJ Publishing Group LTD</pub><pmid>24403282</pmid><doi>10.1136/jnnp-2013-306724</doi><tpages>5</tpages></addata></record> |
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| subjects | Amnesia, Anterograde - blood Amnesia, Anterograde - complications Amnesia, Anterograde - immunology Amnesia, Anterograde - psychology Antibodies - blood Cognitive ability Female Humans Immunoglobulins Immunotherapy Limbic Encephalitis - blood Limbic Encephalitis - complications Limbic Encephalitis - immunology Limbic Encephalitis - psychology Male Memory Middle Aged Neuropsychological Tests Patients Potassium Channels, Voltage-Gated - immunology Studies Variables |
| title | Persistent anterograde amnesia following limbic encephalitis associated with antibodies to the voltage-gated potassium channel complex |
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