Synthesis of Thiohydroxamic Acids and Thiohydroximic Acid Derivatives

An improved and expanded preparation of thiohydroxamic acids is reported along with a one-pot conversion of these compounds to novel thiohydroximic acid derivatives. A variety of aryl, heteroaryl, and alkyl substituents are well tolerated to provide a rapid approach to alkene-functionalized thiohydr...

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Veröffentlicht in:Journal of organic chemistry 2014-03, Vol.79 (5), p.2321-2330
Hauptverfasser: Lemercier, Bérénice C, Pierce, Joshua G
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
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Zusammenfassung:An improved and expanded preparation of thiohydroxamic acids is reported along with a one-pot conversion of these compounds to novel thiohydroximic acid derivatives. A variety of aryl, heteroaryl, and alkyl substituents are well tolerated to provide a rapid approach to alkene-functionalized thiohydroximic acids that serve as potentially useful building blocks for organic synthesis.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo500080x