Lithium and the heart: unanswered questions
Lithium carbonate has been of the most frequently used drugs in the treatment of affective disorders. There was an initial reluctance to prescribe the drug in the United States as lithium chloride had been linked to several cardiac deaths when used as a salt substitute in the treatment of hypertensi...
Gespeichert in:
| Veröffentlicht in: | Chest 1988, Vol.93 (1), p.166-169 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 169 |
|---|---|
| container_issue | 1 |
| container_start_page | 166 |
| container_title | Chest |
| container_volume | 93 |
| creator | BRADY, H. R HORGAN, J. H |
| description | Lithium carbonate has been of the most frequently used drugs in the treatment of affective disorders. There was an initial reluctance to prescribe the drug in the United States as lithium chloride had been linked to several cardiac deaths when used as a salt substitute in the treatment of hypertension. A more critical review of these cases revealed that arrhythmias and hypotension were terminal events in comatose moribund patients and were difficult to ascribe to lithium alone. These observations persuaded the Federal Drug Administration to approve the drug in 1970. Since then, lithium has been implicated in the causation of a variety of cardiac abnormalities. Review of the literature reveals many unanswered questions regarding the prevalence and clinical significance of lithium-related cardiac abnormalities, making it difficult to judge the cardiotoxicity. |
| doi_str_mv | 10.1378/chest.93.1.166 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_15051338</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>15051338</sourcerecordid><originalsourceid>FETCH-LOGICAL-p266t-7289296a9943300876132361d88249ccbc22e137e3111d818a2c166228bdf2823</originalsourceid><addsrcrecordid>eNo9kM1LxDAQxYMo67p69Sb0IF6kNTPTpom3ZfELCl70XNI0pZV-2bSI_71Bi6dh5v2Y92YYuwQeAaXyztTWzZGiCCIQ4ohtQRGElMR0zLacA4YkFJ6yM-c-uO9BiQ3bEKZJgmLLbrNmrpulC3RfBnNtg9rqab4Pll737stOtgw-F-_QDL07ZyeVbp29WOuOvT8-vB2ew-z16eWwz8IRhZjDFKVCJbRSMRHnMhVASAJKKTFWxhQG0frslgD8EKRG46MjyqKsUCLt2M3f3nEafs3zrnHGtq3u7bC4HBKeAJH04NUKLkVny3ycmk5P3_l6ndevV107o9tq0r1p3D-Weib27_oBfFBbUQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>15051338</pqid></control><display><type>article</type><title>Lithium and the heart: unanswered questions</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>BRADY, H. R ; HORGAN, J. H</creator><creatorcontrib>BRADY, H. R ; HORGAN, J. H</creatorcontrib><description>Lithium carbonate has been of the most frequently used drugs in the treatment of affective disorders. There was an initial reluctance to prescribe the drug in the United States as lithium chloride had been linked to several cardiac deaths when used as a salt substitute in the treatment of hypertension. A more critical review of these cases revealed that arrhythmias and hypotension were terminal events in comatose moribund patients and were difficult to ascribe to lithium alone. These observations persuaded the Federal Drug Administration to approve the drug in 1970. Since then, lithium has been implicated in the causation of a variety of cardiac abnormalities. Review of the literature reveals many unanswered questions regarding the prevalence and clinical significance of lithium-related cardiac abnormalities, making it difficult to judge the cardiotoxicity.</description><identifier>ISSN: 0012-3692</identifier><identifier>EISSN: 1931-3543</identifier><identifier>DOI: 10.1378/chest.93.1.166</identifier><identifier>PMID: 3275526</identifier><identifier>CODEN: CHETBF</identifier><language>eng</language><publisher>Northbrook, IL: American College of Chest Physicians</publisher><subject>Arrhythmias, Cardiac - chemically induced ; Biological and medical sciences ; Drug toxicity and drugs side effects treatment ; Electrocardiography ; Heart - drug effects ; Heart Defects, Congenital - chemically induced ; Humans ; Lithium - adverse effects ; Medical sciences ; Myocarditis - chemically induced ; Pharmacology. Drug treatments ; Toxicity: cardiovascular system</subject><ispartof>Chest, 1988, Vol.93 (1), p.166-169</ispartof><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7526419$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3275526$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BRADY, H. R</creatorcontrib><creatorcontrib>HORGAN, J. H</creatorcontrib><title>Lithium and the heart: unanswered questions</title><title>Chest</title><addtitle>Chest</addtitle><description>Lithium carbonate has been of the most frequently used drugs in the treatment of affective disorders. There was an initial reluctance to prescribe the drug in the United States as lithium chloride had been linked to several cardiac deaths when used as a salt substitute in the treatment of hypertension. A more critical review of these cases revealed that arrhythmias and hypotension were terminal events in comatose moribund patients and were difficult to ascribe to lithium alone. These observations persuaded the Federal Drug Administration to approve the drug in 1970. Since then, lithium has been implicated in the causation of a variety of cardiac abnormalities. Review of the literature reveals many unanswered questions regarding the prevalence and clinical significance of lithium-related cardiac abnormalities, making it difficult to judge the cardiotoxicity.</description><subject>Arrhythmias, Cardiac - chemically induced</subject><subject>Biological and medical sciences</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Electrocardiography</subject><subject>Heart - drug effects</subject><subject>Heart Defects, Congenital - chemically induced</subject><subject>Humans</subject><subject>Lithium - adverse effects</subject><subject>Medical sciences</subject><subject>Myocarditis - chemically induced</subject><subject>Pharmacology. Drug treatments</subject><subject>Toxicity: cardiovascular system</subject><issn>0012-3692</issn><issn>1931-3543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kM1LxDAQxYMo67p69Sb0IF6kNTPTpom3ZfELCl70XNI0pZV-2bSI_71Bi6dh5v2Y92YYuwQeAaXyztTWzZGiCCIQ4ohtQRGElMR0zLacA4YkFJ6yM-c-uO9BiQ3bEKZJgmLLbrNmrpulC3RfBnNtg9rqab4Pll737stOtgw-F-_QDL07ZyeVbp29WOuOvT8-vB2ew-z16eWwz8IRhZjDFKVCJbRSMRHnMhVASAJKKTFWxhQG0frslgD8EKRG46MjyqKsUCLt2M3f3nEafs3zrnHGtq3u7bC4HBKeAJH04NUKLkVny3ycmk5P3_l6ndevV107o9tq0r1p3D-Weib27_oBfFBbUQ</recordid><startdate>1988</startdate><enddate>1988</enddate><creator>BRADY, H. R</creator><creator>HORGAN, J. H</creator><general>American College of Chest Physicians</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>1988</creationdate><title>Lithium and the heart: unanswered questions</title><author>BRADY, H. R ; HORGAN, J. H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p266t-7289296a9943300876132361d88249ccbc22e137e3111d818a2c166228bdf2823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Arrhythmias, Cardiac - chemically induced</topic><topic>Biological and medical sciences</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Electrocardiography</topic><topic>Heart - drug effects</topic><topic>Heart Defects, Congenital - chemically induced</topic><topic>Humans</topic><topic>Lithium - adverse effects</topic><topic>Medical sciences</topic><topic>Myocarditis - chemically induced</topic><topic>Pharmacology. Drug treatments</topic><topic>Toxicity: cardiovascular system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BRADY, H. R</creatorcontrib><creatorcontrib>HORGAN, J. H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Chest</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BRADY, H. R</au><au>HORGAN, J. H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lithium and the heart: unanswered questions</atitle><jtitle>Chest</jtitle><addtitle>Chest</addtitle><date>1988</date><risdate>1988</risdate><volume>93</volume><issue>1</issue><spage>166</spage><epage>169</epage><pages>166-169</pages><issn>0012-3692</issn><eissn>1931-3543</eissn><coden>CHETBF</coden><abstract>Lithium carbonate has been of the most frequently used drugs in the treatment of affective disorders. There was an initial reluctance to prescribe the drug in the United States as lithium chloride had been linked to several cardiac deaths when used as a salt substitute in the treatment of hypertension. A more critical review of these cases revealed that arrhythmias and hypotension were terminal events in comatose moribund patients and were difficult to ascribe to lithium alone. These observations persuaded the Federal Drug Administration to approve the drug in 1970. Since then, lithium has been implicated in the causation of a variety of cardiac abnormalities. Review of the literature reveals many unanswered questions regarding the prevalence and clinical significance of lithium-related cardiac abnormalities, making it difficult to judge the cardiotoxicity.</abstract><cop>Northbrook, IL</cop><pub>American College of Chest Physicians</pub><pmid>3275526</pmid><doi>10.1378/chest.93.1.166</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0012-3692 |
| ispartof | Chest, 1988, Vol.93 (1), p.166-169 |
| issn | 0012-3692 1931-3543 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_15051338 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Arrhythmias, Cardiac - chemically induced Biological and medical sciences Drug toxicity and drugs side effects treatment Electrocardiography Heart - drug effects Heart Defects, Congenital - chemically induced Humans Lithium - adverse effects Medical sciences Myocarditis - chemically induced Pharmacology. Drug treatments Toxicity: cardiovascular system |
| title | Lithium and the heart: unanswered questions |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-19T04%3A46%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Lithium%20and%20the%20heart:%20unanswered%20questions&rft.jtitle=Chest&rft.au=BRADY,%20H.%20R&rft.date=1988&rft.volume=93&rft.issue=1&rft.spage=166&rft.epage=169&rft.pages=166-169&rft.issn=0012-3692&rft.eissn=1931-3543&rft.coden=CHETBF&rft_id=info:doi/10.1378/chest.93.1.166&rft_dat=%3Cproquest_pubme%3E15051338%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=15051338&rft_id=info:pmid/3275526&rfr_iscdi=true |