Novel TRPM8 Antagonist Attenuates Cold Hypersensitivity after Peripheral Nerve Injury in Rats

Abnormal cold sensitivity is a common feature of a range of neuropathies. In the murine somatosensory system, multiple aspects of cold sensitivity are dependent on TRPM8, both short term and in response to peripheral nerve injury. The specialized nature of cold-sensitive afferents and the restricted...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of pharmacology and experimental therapeutics 2014-04, Vol.349 (1), p.47-55
Hauptverfasser:	Patel, Ryan, Gonçalves, Leonor, Newman, Robert, Jiang, Feng Li, Goldby, Anne, Reeve, Jennifer, Hendrick, Alan, Teall, Martin, Hannah, Duncan, Almond, Sarah, Brice, Nicola, Dickenson, Anthony H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Behavior, Animal - drug effects Calcium - metabolism Cryopyrin-Associated Periodic Syndromes - etiology Cryopyrin-Associated Periodic Syndromes - metabolism Cryopyrin-Associated Periodic Syndromes - prevention & control Disease Models, Animal Electrophysiological Phenomena HEK293 Cells Humans Male Nicotinic Acids - administration & dosage Nicotinic Acids - pharmacology Nicotinic Acids - therapeutic use Peripheral Nerve Injuries - complications Peripheral Nerve Injuries - metabolism Peripheral Nerve Injuries - psychology Rats Rats, Sprague-Dawley TRPM Cation Channels - antagonists & inhibitors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!