Fertilization-induced K63-linked ubiquitylation mediates clearance of maternal membrane proteins

In Caenorhabditis elegans, fertilization triggers endocytosis and rapid turnover of maternal surface membrane proteins in lysosomes, although the precise mechanism of this inducible endocytosis is unknown. We found that high levels of K63-linked ubiquitin chains transiently accumulated on endosomes...

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Veröffentlicht in:	Development (Cambridge) 2014-03, Vol.141 (6), p.1324-1331
Hauptverfasser:	Sato, Miyuki, Konuma, Ryosuke, Sato, Katsuya, Tomura, Kotone, Sato, Ken
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Genetically Modified Caenorhabditis elegans - genetics Caenorhabditis elegans - growth & development Caenorhabditis elegans - metabolism Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - metabolism Caveolins - genetics Caveolins - metabolism Endocytosis Female Fertilization Genes, Helminth Male Membrane Proteins - genetics Membrane Proteins - metabolism Mutation Oocytes - metabolism Protein Transport Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Ubiquitin-Conjugating Enzymes - genetics Ubiquitin-Conjugating Enzymes - metabolism Ubiquitination Zygote - metabolism
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