Whole-body MRI with diffusion-weighted sequence for staging of patients with suspected ovarian cancer: a clinical feasibility study in comparison to CT and FDG-PET/CT
Objectives To evaluate whole-body MRI with diffusion-weighted sequence (WB-DWI/MRI) for staging and assessing operability compared with CT and FDG-PET/CT in patients with suspected ovarian cancer. Methods Thirty-two patients underwent 3-T WB-DWI/MRI, 18 F-fluorodeoxyglucose positron emission tomogr...
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| Veröffentlicht in: | European radiology 2014-04, Vol.24 (4), p.889-901 |
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| creator | Michielsen, Katrijn Vergote, Ignace Op de beeck, Katya Amant, Frederic Leunen, Karin Moerman, Philippe Deroose, Christophe Souverijns, Geert Dymarkowski, Steven De Keyzer, Frederik Vandecaveye, Vincent |
| description | Objectives
To evaluate whole-body MRI with diffusion-weighted sequence (WB-DWI/MRI) for staging and assessing operability compared with CT and FDG-PET/CT in patients with suspected ovarian cancer.
Methods
Thirty-two patients underwent 3-T WB-DWI/MRI,
18
F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) and CT before diagnostic open laparoscopy (DOL). Imaging findings for tumour characterisation, peritoneal and retroperitoneal staging were correlated with histopathology after DOL and/or open surgery. For distant metastases, FDG-PET/CT or image-guided biopsies were the reference standards. For tumour characterisation and peritoneal staging, WB-DWI/MRI was compared with CT and FDG-PET/CT. Interobserver agreement for WB-DWI/MRI was determined.
Results
WB-DWI/MRI showed 94 % accuracy for primary tumour characterisation compared with 88 % for CT and 94 % for FDG-PET/CT. WB-DWI/MRI showed higher accuracy of 91 % for peritoneal staging compared with CT (75 %) and FDG-PET/CT (71 %). WB-DWI/MRI and FDG-PET/CT showed higher accuracy of 87 % for detecting retroperitoneal lymphadenopathies compared with CT (71 %). WB-DWI/MRI showed excellent correlation with FDG-PET/CT (κ = 1.00) for detecting distant metastases compared with CT (κ = 0.34). Interobserver agreement was moderate to almost perfect (κ = 0.58–0.91).
Conclusions
WB-DWI/MRI shows high accuracy for characterising primary tumours, peritoneal and distant staging compared with CT and FDG-PET/CT and may be valuable for assessing operability in ovarian cancer patients.
Key Points
•
Whole
-
body MRI with diffusion weighting
(
WB
-
DWI
/
MRI
)
helps to assess the operability of suspected ovarian cancer
.
•
Interobserver agreement is good for primary tumour characterisation
,
peritoneal and distant staging
.
•
WB
-
DWI
/
MRI improves mesenteric
/
serosal metastatic spread assessment compared with CT and FDG
-
PET
/
CT
.
•
Retroperitoneal
/
cervical
-
thoracic nodal staging using qualitative DWI criteria was reasonably accurate
.
•
WB
-
DWI
/
MRI and FDG
-
PET
/
CT showed the highest diagnostic impact for detecting thoracic metastases
. |
| doi_str_mv | 10.1007/s00330-013-3083-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1504735666</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1504735666</sourcerecordid><originalsourceid>FETCH-LOGICAL-c420t-6ee461c1672ad026b7f7e30aeb80b4ed932f90436f74c92e0e3c0e654a11ba663</originalsourceid><addsrcrecordid>eNp1kc1u1DAURi0EotOWB2CDLLFhY3ode-KEHZr-UKkIVA1iGTnO9YyrjB3shGpeqM-JpykIIbHywuf7rq8PIa85vOcA6iwBCAEMuGACKsGqZ2TBpSgYh0o-JwuoRcVUXcsjcpzSHQDUXKqX5KjIULHksCAP37ehR9aGbk8_317TezduaeesnZILnt2j22xH7GjCHxN6g9SGSNOoN85vaLB00KNDP6Y5mKY0oDnw4aeOTntqdA7FD1RT0zvvjO6pRZ1c63o37nPTlAe7zIXdkBMpeDoGulpT7Tt6eX7Fvl6sz1brU_LC6j7hq6fzhHy7vFivPrGbL1fXq483zMgCRlYiypIbXqpCd1CUrbIKBWhsK2gldrUobA1SlFZJUxcIKAxguZSa81aXpTgh7-beIYa8cBqbnUsG-157DFNq-BKkEsvyEX37D3oXpujz6x6p_NWcq0zxmTIxpBTRNkN0Ox33DYfmILGZJTZZYnOQ2FQ58-apeWp32P1J_LaWgWIGUr7yG4x_jf5v6y8w9Kfh</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1504091117</pqid></control><display><type>article</type><title>Whole-body MRI with diffusion-weighted sequence for staging of patients with suspected ovarian cancer: a clinical feasibility study in comparison to CT and FDG-PET/CT</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Michielsen, Katrijn ; Vergote, Ignace ; Op de beeck, Katya ; Amant, Frederic ; Leunen, Karin ; Moerman, Philippe ; Deroose, Christophe ; Souverijns, Geert ; Dymarkowski, Steven ; De Keyzer, Frederik ; Vandecaveye, Vincent</creator><creatorcontrib>Michielsen, Katrijn ; Vergote, Ignace ; Op de beeck, Katya ; Amant, Frederic ; Leunen, Karin ; Moerman, Philippe ; Deroose, Christophe ; Souverijns, Geert ; Dymarkowski, Steven ; De Keyzer, Frederik ; Vandecaveye, Vincent</creatorcontrib><description>Objectives
To evaluate whole-body MRI with diffusion-weighted sequence (WB-DWI/MRI) for staging and assessing operability compared with CT and FDG-PET/CT in patients with suspected ovarian cancer.
Methods
Thirty-two patients underwent 3-T WB-DWI/MRI,
18
F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) and CT before diagnostic open laparoscopy (DOL). Imaging findings for tumour characterisation, peritoneal and retroperitoneal staging were correlated with histopathology after DOL and/or open surgery. For distant metastases, FDG-PET/CT or image-guided biopsies were the reference standards. For tumour characterisation and peritoneal staging, WB-DWI/MRI was compared with CT and FDG-PET/CT. Interobserver agreement for WB-DWI/MRI was determined.
Results
WB-DWI/MRI showed 94 % accuracy for primary tumour characterisation compared with 88 % for CT and 94 % for FDG-PET/CT. WB-DWI/MRI showed higher accuracy of 91 % for peritoneal staging compared with CT (75 %) and FDG-PET/CT (71 %). WB-DWI/MRI and FDG-PET/CT showed higher accuracy of 87 % for detecting retroperitoneal lymphadenopathies compared with CT (71 %). WB-DWI/MRI showed excellent correlation with FDG-PET/CT (κ = 1.00) for detecting distant metastases compared with CT (κ = 0.34). Interobserver agreement was moderate to almost perfect (κ = 0.58–0.91).
Conclusions
WB-DWI/MRI shows high accuracy for characterising primary tumours, peritoneal and distant staging compared with CT and FDG-PET/CT and may be valuable for assessing operability in ovarian cancer patients.
Key Points
•
Whole
-
body MRI with diffusion weighting
(
WB
-
DWI
/
MRI
)
helps to assess the operability of suspected ovarian cancer
.
•
Interobserver agreement is good for primary tumour characterisation
,
peritoneal and distant staging
.
•
WB
-
DWI
/
MRI improves mesenteric
/
serosal metastatic spread assessment compared with CT and FDG
-
PET
/
CT
.
•
Retroperitoneal
/
cervical
-
thoracic nodal staging using qualitative DWI criteria was reasonably accurate
.
•
WB
-
DWI
/
MRI and FDG
-
PET
/
CT showed the highest diagnostic impact for detecting thoracic metastases
.</description><identifier>ISSN: 0938-7994</identifier><identifier>EISSN: 1432-1084</identifier><identifier>DOI: 10.1007/s00330-013-3083-8</identifier><identifier>PMID: 24322510</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Carcinoma - pathology ; Diagnostic Radiology ; Diffusion ; Diffusion Magnetic Resonance Imaging - methods ; Feasibility Studies ; Female ; Fluorodeoxyglucose F18 ; Humans ; Image-Guided Biopsy ; Imaging ; Internal Medicine ; Interventional Radiology ; Lymph Nodes - pathology ; Medicine ; Medicine & Public Health ; Middle Aged ; Neoplasm Staging ; Neuroradiology ; Ovarian cancer ; Ovarian Neoplasms - pathology ; Positron-Emission Tomography - methods ; Radiology ; Radiopharmaceuticals ; Tomography, X-Ray Computed - methods ; Ultrasound ; Urogenital ; Whole Body Imaging ; Young Adult</subject><ispartof>European radiology, 2014-04, Vol.24 (4), p.889-901</ispartof><rights>European Society of Radiology 2013</rights><rights>European Society of Radiology 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-6ee461c1672ad026b7f7e30aeb80b4ed932f90436f74c92e0e3c0e654a11ba663</citedby><cites>FETCH-LOGICAL-c420t-6ee461c1672ad026b7f7e30aeb80b4ed932f90436f74c92e0e3c0e654a11ba663</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00330-013-3083-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00330-013-3083-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24322510$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Michielsen, Katrijn</creatorcontrib><creatorcontrib>Vergote, Ignace</creatorcontrib><creatorcontrib>Op de beeck, Katya</creatorcontrib><creatorcontrib>Amant, Frederic</creatorcontrib><creatorcontrib>Leunen, Karin</creatorcontrib><creatorcontrib>Moerman, Philippe</creatorcontrib><creatorcontrib>Deroose, Christophe</creatorcontrib><creatorcontrib>Souverijns, Geert</creatorcontrib><creatorcontrib>Dymarkowski, Steven</creatorcontrib><creatorcontrib>De Keyzer, Frederik</creatorcontrib><creatorcontrib>Vandecaveye, Vincent</creatorcontrib><title>Whole-body MRI with diffusion-weighted sequence for staging of patients with suspected ovarian cancer: a clinical feasibility study in comparison to CT and FDG-PET/CT</title><title>European radiology</title><addtitle>Eur Radiol</addtitle><addtitle>Eur Radiol</addtitle><description>Objectives
To evaluate whole-body MRI with diffusion-weighted sequence (WB-DWI/MRI) for staging and assessing operability compared with CT and FDG-PET/CT in patients with suspected ovarian cancer.
Methods
Thirty-two patients underwent 3-T WB-DWI/MRI,
18
F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) and CT before diagnostic open laparoscopy (DOL). Imaging findings for tumour characterisation, peritoneal and retroperitoneal staging were correlated with histopathology after DOL and/or open surgery. For distant metastases, FDG-PET/CT or image-guided biopsies were the reference standards. For tumour characterisation and peritoneal staging, WB-DWI/MRI was compared with CT and FDG-PET/CT. Interobserver agreement for WB-DWI/MRI was determined.
Results
WB-DWI/MRI showed 94 % accuracy for primary tumour characterisation compared with 88 % for CT and 94 % for FDG-PET/CT. WB-DWI/MRI showed higher accuracy of 91 % for peritoneal staging compared with CT (75 %) and FDG-PET/CT (71 %). WB-DWI/MRI and FDG-PET/CT showed higher accuracy of 87 % for detecting retroperitoneal lymphadenopathies compared with CT (71 %). WB-DWI/MRI showed excellent correlation with FDG-PET/CT (κ = 1.00) for detecting distant metastases compared with CT (κ = 0.34). Interobserver agreement was moderate to almost perfect (κ = 0.58–0.91).
Conclusions
WB-DWI/MRI shows high accuracy for characterising primary tumours, peritoneal and distant staging compared with CT and FDG-PET/CT and may be valuable for assessing operability in ovarian cancer patients.
Key Points
•
Whole
-
body MRI with diffusion weighting
(
WB
-
DWI
/
MRI
)
helps to assess the operability of suspected ovarian cancer
.
•
Interobserver agreement is good for primary tumour characterisation
,
peritoneal and distant staging
.
•
WB
-
DWI
/
MRI improves mesenteric
/
serosal metastatic spread assessment compared with CT and FDG
-
PET
/
CT
.
•
Retroperitoneal
/
cervical
-
thoracic nodal staging using qualitative DWI criteria was reasonably accurate
.
•
WB
-
DWI
/
MRI and FDG
-
PET
/
CT showed the highest diagnostic impact for detecting thoracic metastases
.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Carcinoma - pathology</subject><subject>Diagnostic Radiology</subject><subject>Diffusion</subject><subject>Diffusion Magnetic Resonance Imaging - methods</subject><subject>Feasibility Studies</subject><subject>Female</subject><subject>Fluorodeoxyglucose F18</subject><subject>Humans</subject><subject>Image-Guided Biopsy</subject><subject>Imaging</subject><subject>Internal Medicine</subject><subject>Interventional Radiology</subject><subject>Lymph Nodes - pathology</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Neuroradiology</subject><subject>Ovarian cancer</subject><subject>Ovarian Neoplasms - pathology</subject><subject>Positron-Emission Tomography - methods</subject><subject>Radiology</subject><subject>Radiopharmaceuticals</subject><subject>Tomography, X-Ray Computed - methods</subject><subject>Ultrasound</subject><subject>Urogenital</subject><subject>Whole Body Imaging</subject><subject>Young Adult</subject><issn>0938-7994</issn><issn>1432-1084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kc1u1DAURi0EotOWB2CDLLFhY3ode-KEHZr-UKkIVA1iGTnO9YyrjB3shGpeqM-JpykIIbHywuf7rq8PIa85vOcA6iwBCAEMuGACKsGqZ2TBpSgYh0o-JwuoRcVUXcsjcpzSHQDUXKqX5KjIULHksCAP37ehR9aGbk8_317TezduaeesnZILnt2j22xH7GjCHxN6g9SGSNOoN85vaLB00KNDP6Y5mKY0oDnw4aeOTntqdA7FD1RT0zvvjO6pRZ1c63o37nPTlAe7zIXdkBMpeDoGulpT7Tt6eX7Fvl6sz1brU_LC6j7hq6fzhHy7vFivPrGbL1fXq483zMgCRlYiypIbXqpCd1CUrbIKBWhsK2gldrUobA1SlFZJUxcIKAxguZSa81aXpTgh7-beIYa8cBqbnUsG-157DFNq-BKkEsvyEX37D3oXpujz6x6p_NWcq0zxmTIxpBTRNkN0Ox33DYfmILGZJTZZYnOQ2FQ58-apeWp32P1J_LaWgWIGUr7yG4x_jf5v6y8w9Kfh</recordid><startdate>20140401</startdate><enddate>20140401</enddate><creator>Michielsen, Katrijn</creator><creator>Vergote, Ignace</creator><creator>Op de beeck, Katya</creator><creator>Amant, Frederic</creator><creator>Leunen, Karin</creator><creator>Moerman, Philippe</creator><creator>Deroose, Christophe</creator><creator>Souverijns, Geert</creator><creator>Dymarkowski, Steven</creator><creator>De Keyzer, Frederik</creator><creator>Vandecaveye, Vincent</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20140401</creationdate><title>Whole-body MRI with diffusion-weighted sequence for staging of patients with suspected ovarian cancer: a clinical feasibility study in comparison to CT and FDG-PET/CT</title><author>Michielsen, Katrijn ; Vergote, Ignace ; Op de beeck, Katya ; Amant, Frederic ; Leunen, Karin ; Moerman, Philippe ; Deroose, Christophe ; Souverijns, Geert ; Dymarkowski, Steven ; De Keyzer, Frederik ; Vandecaveye, Vincent</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-6ee461c1672ad026b7f7e30aeb80b4ed932f90436f74c92e0e3c0e654a11ba663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Carcinoma - pathology</topic><topic>Diagnostic Radiology</topic><topic>Diffusion</topic><topic>Diffusion Magnetic Resonance Imaging - methods</topic><topic>Feasibility Studies</topic><topic>Female</topic><topic>Fluorodeoxyglucose F18</topic><topic>Humans</topic><topic>Image-Guided Biopsy</topic><topic>Imaging</topic><topic>Internal Medicine</topic><topic>Interventional Radiology</topic><topic>Lymph Nodes - pathology</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Neuroradiology</topic><topic>Ovarian cancer</topic><topic>Ovarian Neoplasms - pathology</topic><topic>Positron-Emission Tomography - methods</topic><topic>Radiology</topic><topic>Radiopharmaceuticals</topic><topic>Tomography, X-Ray Computed - methods</topic><topic>Ultrasound</topic><topic>Urogenital</topic><topic>Whole Body Imaging</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Michielsen, Katrijn</creatorcontrib><creatorcontrib>Vergote, Ignace</creatorcontrib><creatorcontrib>Op de beeck, Katya</creatorcontrib><creatorcontrib>Amant, Frederic</creatorcontrib><creatorcontrib>Leunen, Karin</creatorcontrib><creatorcontrib>Moerman, Philippe</creatorcontrib><creatorcontrib>Deroose, Christophe</creatorcontrib><creatorcontrib>Souverijns, Geert</creatorcontrib><creatorcontrib>Dymarkowski, Steven</creatorcontrib><creatorcontrib>De Keyzer, Frederik</creatorcontrib><creatorcontrib>Vandecaveye, Vincent</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>European radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Michielsen, Katrijn</au><au>Vergote, Ignace</au><au>Op de beeck, Katya</au><au>Amant, Frederic</au><au>Leunen, Karin</au><au>Moerman, Philippe</au><au>Deroose, Christophe</au><au>Souverijns, Geert</au><au>Dymarkowski, Steven</au><au>De Keyzer, Frederik</au><au>Vandecaveye, Vincent</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Whole-body MRI with diffusion-weighted sequence for staging of patients with suspected ovarian cancer: a clinical feasibility study in comparison to CT and FDG-PET/CT</atitle><jtitle>European radiology</jtitle><stitle>Eur Radiol</stitle><addtitle>Eur Radiol</addtitle><date>2014-04-01</date><risdate>2014</risdate><volume>24</volume><issue>4</issue><spage>889</spage><epage>901</epage><pages>889-901</pages><issn>0938-7994</issn><eissn>1432-1084</eissn><abstract>Objectives
To evaluate whole-body MRI with diffusion-weighted sequence (WB-DWI/MRI) for staging and assessing operability compared with CT and FDG-PET/CT in patients with suspected ovarian cancer.
Methods
Thirty-two patients underwent 3-T WB-DWI/MRI,
18
F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) and CT before diagnostic open laparoscopy (DOL). Imaging findings for tumour characterisation, peritoneal and retroperitoneal staging were correlated with histopathology after DOL and/or open surgery. For distant metastases, FDG-PET/CT or image-guided biopsies were the reference standards. For tumour characterisation and peritoneal staging, WB-DWI/MRI was compared with CT and FDG-PET/CT. Interobserver agreement for WB-DWI/MRI was determined.
Results
WB-DWI/MRI showed 94 % accuracy for primary tumour characterisation compared with 88 % for CT and 94 % for FDG-PET/CT. WB-DWI/MRI showed higher accuracy of 91 % for peritoneal staging compared with CT (75 %) and FDG-PET/CT (71 %). WB-DWI/MRI and FDG-PET/CT showed higher accuracy of 87 % for detecting retroperitoneal lymphadenopathies compared with CT (71 %). WB-DWI/MRI showed excellent correlation with FDG-PET/CT (κ = 1.00) for detecting distant metastases compared with CT (κ = 0.34). Interobserver agreement was moderate to almost perfect (κ = 0.58–0.91).
Conclusions
WB-DWI/MRI shows high accuracy for characterising primary tumours, peritoneal and distant staging compared with CT and FDG-PET/CT and may be valuable for assessing operability in ovarian cancer patients.
Key Points
•
Whole
-
body MRI with diffusion weighting
(
WB
-
DWI
/
MRI
)
helps to assess the operability of suspected ovarian cancer
.
•
Interobserver agreement is good for primary tumour characterisation
,
peritoneal and distant staging
.
•
WB
-
DWI
/
MRI improves mesenteric
/
serosal metastatic spread assessment compared with CT and FDG
-
PET
/
CT
.
•
Retroperitoneal
/
cervical
-
thoracic nodal staging using qualitative DWI criteria was reasonably accurate
.
•
WB
-
DWI
/
MRI and FDG
-
PET
/
CT showed the highest diagnostic impact for detecting thoracic metastases
.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>24322510</pmid><doi>10.1007/s00330-013-3083-8</doi><tpages>13</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0938-7994 |
| ispartof | European radiology, 2014-04, Vol.24 (4), p.889-901 |
| issn | 0938-7994 1432-1084 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1504735666 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adult Aged Aged, 80 and over Carcinoma - pathology Diagnostic Radiology Diffusion Diffusion Magnetic Resonance Imaging - methods Feasibility Studies Female Fluorodeoxyglucose F18 Humans Image-Guided Biopsy Imaging Internal Medicine Interventional Radiology Lymph Nodes - pathology Medicine Medicine & Public Health Middle Aged Neoplasm Staging Neuroradiology Ovarian cancer Ovarian Neoplasms - pathology Positron-Emission Tomography - methods Radiology Radiopharmaceuticals Tomography, X-Ray Computed - methods Ultrasound Urogenital Whole Body Imaging Young Adult |
| title | Whole-body MRI with diffusion-weighted sequence for staging of patients with suspected ovarian cancer: a clinical feasibility study in comparison to CT and FDG-PET/CT |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T05%3A51%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Whole-body%20MRI%20with%20diffusion-weighted%20sequence%20for%20staging%20of%20patients%20with%20suspected%20ovarian%20cancer:%20a%20clinical%20feasibility%20study%20in%20comparison%20to%20CT%20and%20FDG-PET/CT&rft.jtitle=European%20radiology&rft.au=Michielsen,%20Katrijn&rft.date=2014-04-01&rft.volume=24&rft.issue=4&rft.spage=889&rft.epage=901&rft.pages=889-901&rft.issn=0938-7994&rft.eissn=1432-1084&rft_id=info:doi/10.1007/s00330-013-3083-8&rft_dat=%3Cproquest_cross%3E1504735666%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1504091117&rft_id=info:pmid/24322510&rfr_iscdi=true |