Protective Effect of Esculin on Streptozotocin-Induced Diabetic Renal Damage in Mice

The present study investigated the presence and mechanism of esculin-mediated renoprotection to assess its therapeutic potential. Esculin was orally administered at 20 mg/kg/day for 2 weeks to streptozotocin-induced diabetic mice, and its effects were compared with those of the vehicle in normal and...

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Veröffentlicht in:	Journal of agricultural and food chemistry 2014-03, Vol.62 (9), p.2069-2076
Hauptverfasser:	Kang, Ki Sung, Lee, Woojung, Jung, Yujung, Lee, Ji Hwan, Lee, Seungyong, Eom, Dae-Woon, Jeon, Youngsic, Yoo, Hye Hyun, Jin, Ming Ji, Song, Kyung Il, Kim, Won Jun, Ham, Jungyeob, Kim, Hyoung Ja, Kim, Su-Nam
Format:	Artikel
Sprache:	eng
Schlagworte:	animal disease models Animals blood blood glucose Blood Glucose - metabolism Caspase 3 - metabolism caspase-3 creatinine diabetes mellitus Diabetic Nephropathies - drug therapy Diabetic Nephropathies - metabolism Diabetic Nephropathies - prevention & control Esculin - administration & dosage glucose glucose-6-phosphatase glycemic effect glycogen synthase kinases Humans Insulin - metabolism insulin receptors insulin resistance Kidney - drug effects Kidney - enzymology kidneys Male Mice Mice, Inbred ICR myotubes oral administration phosphorylation protective effect Streptozocin - adverse effects tau-protein kinase
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