Increased mortality in systemic inflammatory response syndrome patients with high levels of coagulation factor VIIa

Summary Background The tissue factor (TF)‐ Factor VIIa (FVIIa) complex has a pivotal role in inflammatory and coagulation responses in patients with systemic inflammatory response syndrome (SIRS) and sepsis. Because zymogen FVII (FVII) and FVIIa compete for binding to TF, their plasma levels determi...

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Veröffentlicht in:	Journal of thrombosis and haemostasis 2013-12, Vol.11 (12), p.2111-2117
Hauptverfasser:	Hyseni, A., Kemperman, H., Lange, D. W., Groot, P. G., Linssen, M., Kesecioglu, J., Lisman, T., Roest, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over APACHE Cohort Studies critical care Enzyme-Linked Immunosorbent Assay factor VII factor VIIa Factor VIIa - metabolism Female Humans Male Middle Aged sepsis systemic inflammatory response syndrome Systemic Inflammatory Response Syndrome - blood Systemic Inflammatory Response Syndrome - mortality tissue factor
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