Synthesis of Imperatorin Analogs and Their Evaluation as Acetylcholinesterase and Butyrylcholinesterase Inhibitors

In this study, we synthesized several imperatorin analogs using imperatorin and xanthotoxin as substrates. The anti‐cholinesterase activities of all compounds were evaluated in in vitro experiments according to the modified Ellman's method. For each synthesized compound, IC50 values for both en...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Archiv der Pharmazie (Weinheim) 2013-11, Vol.346 (11), p.775-782
Hauptverfasser:	Granica, Sebastian, Kiss, Anna K., Jarończyk, Małgorzata, Maurin, Jan K., Mazurek, Aleksander P., Czarnocki, Zbigniew
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase Acetylcholinesterase - metabolism Alzheimer Disease - drug therapy Alzheimer Disease - enzymology Alzheimer's disease Angelica archangelica Animals Binding Sites Butyrylcholinesterase Butyrylcholinesterase - metabolism Cholinesterase Inhibitors - chemical synthesis Cholinesterase Inhibitors - pharmacology Furocoumarins Furocoumarins - chemical synthesis Furocoumarins - pharmacology Galantamine - pharmacology Molecular Docking Simulation Structure-Activity Relationship
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!