Exploration of optimal dosing regimens of vancomycin in patients infected with methicillin-resistant Staphylococcus aureus by modeling and simulation

Summary What is known and objective Vancomycin is the drug of choice for methicillin‐resistant Staphylococcus aureus (MRSA) infection and shows time‐dependent bacterial killing. The current study evaluated the pharmacokinetics (PK) and pharmacodynamics (PD) of vancomycin and explored its optimal dos...

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Veröffentlicht in:	Journal of clinical pharmacy and therapeutics 2014-04, Vol.39 (2), p.196-203
Hauptverfasser:	Lim, H.-S., Chong, Y. P., Noh, Y.-H., Jung, J.-A., Kim, Y. S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - pharmacokinetics Anti-Bacterial Agents - pharmacology Biological and medical sciences Computer Simulation Dose-Response Relationship, Drug Female Humans Male Medical sciences Methicillin-Resistant Staphylococcus aureus - drug effects Microbial Sensitivity Tests Middle Aged Models, Biological Nonlinear Dynamics optimal dosing regimen pharmacokinetics/pharmacodynamics Pharmacology. Drug treatments simulation Staphylococcal Infections - drug therapy Staphylococcal Infections - microbiology Time Factors vancomycin Vancomycin - administration & dosage Vancomycin - pharmacokinetics Vancomycin - pharmacology Young Adult
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