Bicyclic Peptide Inhibitor of Urokinase-Type Plasminogen Activator: Mode of Action

The development of protease inhibitors for pharmacological intervention has taken a new turn with the use of peptide‐based inhibitors. Here, we report the rational design of bicyclic peptide inhibitors of the serine protease urokinase‐type plasminogen activator (uPA), based on the established monocy...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2013-11, Vol.14 (16), p.2179-2188
Hauptverfasser:	Roodbeen, Renée, Paaske, Berit, Jiang, Longguang, Jensen, Jan K., Christensen, Anni, Nielsen, Jakob T., Huang, Mingdong, Mulder, Frans A. A., Nielsen, Niels Chr, Andreasen, Peter A., Jensen, Knud J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Binding Sites cancer Crystallography, X-Ray Drug Design Humans isothermal titration calorimetry Kinetics NMR spectroscopy peptide-protease interactions Peptides Peptides, Cyclic - chemical synthesis Peptides, Cyclic - chemistry Peptides, Cyclic - metabolism Protease inhibitors Protease Inhibitors - chemical synthesis Protease Inhibitors - chemistry Protease Inhibitors - metabolism Proteases Protein Binding Protein Structure, Secondary Protein Structure, Tertiary Urokinase-Type Plasminogen Activator - antagonists & inhibitors Urokinase-Type Plasminogen Activator - metabolism X-ray structures
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