A Fluorogenic Probe with Aggregation-Induced Emission Characteristics for Carboxylesterase Assay through Formation of Supramolecular Microfibers
Herein, we report a novel fluorescent “light‐up” probe useful for carboxylesterase assay that is based on a tetraphenylethylene derivative containing carboxylic ester groups. The specific cleavage of the carboxylic ester bonds by carboxylesterase results in the generation of a relatively hydrophobic...
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| Veröffentlicht in: | Chemistry, an Asian journal an Asian journal, 2014-03, Vol.9 (3), p.784-789 |
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| container_end_page | 789 |
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| container_issue | 3 |
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| container_title | Chemistry, an Asian journal |
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| creator | Wang, Xiaojing Liu, Huan Li, Jingwen Ding, Kaiguo Lv, Zhonglin Yang, Yonggang Chen, Hong Li, Xinming |
| description | Herein, we report a novel fluorescent “light‐up” probe useful for carboxylesterase assay that is based on a tetraphenylethylene derivative containing carboxylic ester groups. The specific cleavage of the carboxylic ester bonds by carboxylesterase results in the generation of a relatively hydrophobic moiety that self‐assembles into supramolecular microfibers, thus giving rise to “turn‐on” fluorescent signals. A high sensitivity towards carboxylesterase was achieved with a detection limit as low as 29 pM, which is much lower than the corresponding assays based on other fluorescent approaches.
A million little fibers: A novel fluorogenic probe based on a tetraphenylethylene derivative containing carboxylic ester groups for carboxylesterase recognition was designed and synthesized. The specific cleavage of the carboxylic ester bond by carboxylesterase results in the generation of a relatively hydrophobic moiety that self‐assembles into highly fluorescent supramolecular microfibers, thus giving rise to “turn‐on” fluorescent signals. |
| doi_str_mv | 10.1002/asia.201301326 |
| format | Article |
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A million little fibers: A novel fluorogenic probe based on a tetraphenylethylene derivative containing carboxylic ester groups for carboxylesterase recognition was designed and synthesized. The specific cleavage of the carboxylic ester bond by carboxylesterase results in the generation of a relatively hydrophobic moiety that self‐assembles into highly fluorescent supramolecular microfibers, thus giving rise to “turn‐on” fluorescent signals.</description><identifier>ISSN: 1861-4728</identifier><identifier>EISSN: 1861-471X</identifier><identifier>DOI: 10.1002/asia.201301326</identifier><identifier>PMID: 24403215</identifier><language>eng</language><publisher>Weinheim: WILEY-VCH Verlag</publisher><subject>aggregation-induced emission ; carboxylesterase ; Carboxylesterase - analysis ; Carboxylesterase - metabolism ; Chemistry ; Enzyme Assays ; fluorescence ; Fluorescent Dyes - analysis ; Fluorescent Dyes - chemistry ; Hydrophobic and Hydrophilic Interactions ; Macromolecular Substances - chemistry ; Molecular Structure ; Particle Size ; self-assembly ; Surface Properties ; tetraphenylethylene</subject><ispartof>Chemistry, an Asian journal, 2014-03, Vol.9 (3), p.784-789</ispartof><rights>Copyright © 2014 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><rights>Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4486-ef8876fc95b005544ae550d28dd27d3fecb7884d9c7c2d067d879109222d13a93</citedby><cites>FETCH-LOGICAL-c4486-ef8876fc95b005544ae550d28dd27d3fecb7884d9c7c2d067d879109222d13a93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fasia.201301326$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fasia.201301326$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27922,27923,45572,45573</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24403215$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Xiaojing</creatorcontrib><creatorcontrib>Liu, Huan</creatorcontrib><creatorcontrib>Li, Jingwen</creatorcontrib><creatorcontrib>Ding, Kaiguo</creatorcontrib><creatorcontrib>Lv, Zhonglin</creatorcontrib><creatorcontrib>Yang, Yonggang</creatorcontrib><creatorcontrib>Chen, Hong</creatorcontrib><creatorcontrib>Li, Xinming</creatorcontrib><title>A Fluorogenic Probe with Aggregation-Induced Emission Characteristics for Carboxylesterase Assay through Formation of Supramolecular Microfibers</title><title>Chemistry, an Asian journal</title><addtitle>Chem. Asian J</addtitle><description>Herein, we report a novel fluorescent “light‐up” probe useful for carboxylesterase assay that is based on a tetraphenylethylene derivative containing carboxylic ester groups. The specific cleavage of the carboxylic ester bonds by carboxylesterase results in the generation of a relatively hydrophobic moiety that self‐assembles into supramolecular microfibers, thus giving rise to “turn‐on” fluorescent signals. A high sensitivity towards carboxylesterase was achieved with a detection limit as low as 29 pM, which is much lower than the corresponding assays based on other fluorescent approaches.
A million little fibers: A novel fluorogenic probe based on a tetraphenylethylene derivative containing carboxylic ester groups for carboxylesterase recognition was designed and synthesized. The specific cleavage of the carboxylic ester bond by carboxylesterase results in the generation of a relatively hydrophobic moiety that self‐assembles into highly fluorescent supramolecular microfibers, thus giving rise to “turn‐on” fluorescent signals.</description><subject>aggregation-induced emission</subject><subject>carboxylesterase</subject><subject>Carboxylesterase - analysis</subject><subject>Carboxylesterase - metabolism</subject><subject>Chemistry</subject><subject>Enzyme Assays</subject><subject>fluorescence</subject><subject>Fluorescent Dyes - analysis</subject><subject>Fluorescent Dyes - chemistry</subject><subject>Hydrophobic and Hydrophilic Interactions</subject><subject>Macromolecular Substances - chemistry</subject><subject>Molecular Structure</subject><subject>Particle Size</subject><subject>self-assembly</subject><subject>Surface Properties</subject><subject>tetraphenylethylene</subject><issn>1861-4728</issn><issn>1861-471X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFu1DAQhiMEoqVw5YgsceGSxXZsxzmGVbcsKtBSENwsx55kXZJ4sTdq9y36yPWyZYW4IFkaa_TNpxn9WfaS4BnBmL7V0ekZxaRIj4pH2TGRguSsJD8eH_5UHmXPYrzGmFNcyafZEWUMF5Tw4-yuRot-8sF3MDqDLoJvAN24zQrVXReg0xvnx3w52smARaeDizE10HylgzYbCC5unImo9QHNdWj87baHmPo6Aqpj1Fu0WQU_dSu08GH4bUO-RVfTOujB92CmXgf00ZngW9dAiM-zJ63uI7x4qCfZt8Xp1_n7_Pzz2XJen-eGMSlyaKUsRWsq3qSzOGMaOMeWSmtpaYsWTFNKyWxlSkMtFqWVZUVwRSm1pNBVcZK92XvXwf-a0s4q3Wag7_UIfoqKcMwYp5UQCX39D3rtpzCm7XZUcmNGd8LZnkqnxBigVevgBh22imC1y0rtslKHrNLAqwft1AxgD_ifcBJQ7YEb18P2PzpVXy3rv-X5fjYFBLeHWR1-KlEWJVffP50pfiEuL9-JD-pLcQ9DhrG2</recordid><startdate>201403</startdate><enddate>201403</enddate><creator>Wang, Xiaojing</creator><creator>Liu, Huan</creator><creator>Li, Jingwen</creator><creator>Ding, Kaiguo</creator><creator>Lv, Zhonglin</creator><creator>Yang, Yonggang</creator><creator>Chen, Hong</creator><creator>Li, Xinming</creator><general>WILEY-VCH Verlag</general><general>WILEY‐VCH Verlag</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201403</creationdate><title>A Fluorogenic Probe with Aggregation-Induced Emission Characteristics for Carboxylesterase Assay through Formation of Supramolecular Microfibers</title><author>Wang, Xiaojing ; Liu, Huan ; Li, Jingwen ; Ding, Kaiguo ; Lv, Zhonglin ; Yang, Yonggang ; Chen, Hong ; Li, Xinming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4486-ef8876fc95b005544ae550d28dd27d3fecb7884d9c7c2d067d879109222d13a93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>aggregation-induced emission</topic><topic>carboxylesterase</topic><topic>Carboxylesterase - analysis</topic><topic>Carboxylesterase - metabolism</topic><topic>Chemistry</topic><topic>Enzyme Assays</topic><topic>fluorescence</topic><topic>Fluorescent Dyes - analysis</topic><topic>Fluorescent Dyes - chemistry</topic><topic>Hydrophobic and Hydrophilic Interactions</topic><topic>Macromolecular Substances - chemistry</topic><topic>Molecular Structure</topic><topic>Particle Size</topic><topic>self-assembly</topic><topic>Surface Properties</topic><topic>tetraphenylethylene</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Xiaojing</creatorcontrib><creatorcontrib>Liu, Huan</creatorcontrib><creatorcontrib>Li, Jingwen</creatorcontrib><creatorcontrib>Ding, Kaiguo</creatorcontrib><creatorcontrib>Lv, Zhonglin</creatorcontrib><creatorcontrib>Yang, Yonggang</creatorcontrib><creatorcontrib>Chen, Hong</creatorcontrib><creatorcontrib>Li, Xinming</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Chemistry, an Asian journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Xiaojing</au><au>Liu, Huan</au><au>Li, Jingwen</au><au>Ding, Kaiguo</au><au>Lv, Zhonglin</au><au>Yang, Yonggang</au><au>Chen, Hong</au><au>Li, Xinming</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Fluorogenic Probe with Aggregation-Induced Emission Characteristics for Carboxylesterase Assay through Formation of Supramolecular Microfibers</atitle><jtitle>Chemistry, an Asian journal</jtitle><addtitle>Chem. Asian J</addtitle><date>2014-03</date><risdate>2014</risdate><volume>9</volume><issue>3</issue><spage>784</spage><epage>789</epage><pages>784-789</pages><issn>1861-4728</issn><eissn>1861-471X</eissn><abstract>Herein, we report a novel fluorescent “light‐up” probe useful for carboxylesterase assay that is based on a tetraphenylethylene derivative containing carboxylic ester groups. The specific cleavage of the carboxylic ester bonds by carboxylesterase results in the generation of a relatively hydrophobic moiety that self‐assembles into supramolecular microfibers, thus giving rise to “turn‐on” fluorescent signals. A high sensitivity towards carboxylesterase was achieved with a detection limit as low as 29 pM, which is much lower than the corresponding assays based on other fluorescent approaches.
A million little fibers: A novel fluorogenic probe based on a tetraphenylethylene derivative containing carboxylic ester groups for carboxylesterase recognition was designed and synthesized. The specific cleavage of the carboxylic ester bond by carboxylesterase results in the generation of a relatively hydrophobic moiety that self‐assembles into highly fluorescent supramolecular microfibers, thus giving rise to “turn‐on” fluorescent signals.</abstract><cop>Weinheim</cop><pub>WILEY-VCH Verlag</pub><pmid>24403215</pmid><doi>10.1002/asia.201301326</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | aggregation-induced emission carboxylesterase Carboxylesterase - analysis Carboxylesterase - metabolism Chemistry Enzyme Assays fluorescence Fluorescent Dyes - analysis Fluorescent Dyes - chemistry Hydrophobic and Hydrophilic Interactions Macromolecular Substances - chemistry Molecular Structure Particle Size self-assembly Surface Properties tetraphenylethylene |
| title | A Fluorogenic Probe with Aggregation-Induced Emission Characteristics for Carboxylesterase Assay through Formation of Supramolecular Microfibers |
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