The effect of smoking cessation on airway inflammation in young asthma patients
Summary Background Smoking has been shown to have several detrimental effects on asthma, including poor symptom control, attenuated treatment response and accelerated decline in lung function. In spite of this, smoking is at least as common among asthma patients as in the rest of the population. The...
Gespeichert in:
| Veröffentlicht in: | Clinical and experimental allergy 2014-03, Vol.44 (3), p.353-361 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 361 |
|---|---|
| container_issue | 3 |
| container_start_page | 353 |
| container_title | Clinical and experimental allergy |
| container_volume | 44 |
| creator | Westergaard, C. G. Porsbjerg, C. Backer, V. |
| description | Summary
Background
Smoking has been shown to have several detrimental effects on asthma, including poor symptom control, attenuated treatment response and accelerated decline in lung function. In spite of this, smoking is at least as common among asthma patients as in the rest of the population. The aggravations of smoking on asthma may be caused by effects on airway inflammation, which has been found to be changed in asthmatic smokers. It is not known whether these smoking‐induced airway inflammation changes are reversible after smoking cessation.
Objective
The aim of this study was to assess airway changes in asthmatic smokers before and during smoking cessation.
Methods
Forty‐six smokers with asthma, all steroid‐free (age range: 19–40), were recruited. All participants attempted smoking cessation over a period of 3 months. Visits were performed at weeks 0, 6 and 12 and included induced sputum, FeNO, methacholine challenge, lung function, Asthma Control Questionnaire (ACQ6) and exhaled CO.
Results
Twenty‐six of 46 patients succeeded in quitting smoking. In the quitters, improvements in methacholine AHR (77% before and 52% after smoking cessation, respectively, P = 0.016) and ACQ6 score (1.7–0.7, P = 0.034) and FeNO (8.7–14.8 p.p.b., P = 0.002) were observed, whereas no significant changes were found regarding eosinophils or lung function. A small but significant decrease in neutrophils (54.1–52%, P = 0.003) was present in quitters compared with the non‐quitters. Non‐quitters experienced no changes in any parameters.
Conclusion
Smoking cessation improved asthma control, but the changes were not related to change in eosinophilic inflammation, and the reduction in neutrophils was small. Thus, airway inflammation with eosinophils and neutrophils may be less important drivers of asthma control in smokers than other factors.
Clinical Relevance
Smoking cessation may improve clinically important disease parameters such as AHR and symptom score, but likely unrelated to changes in airway inflammation. |
| doi_str_mv | 10.1111/cea.12243 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1504452703</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3309976521</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4923-44691675545a70e2b1fdf2693c55c9e7fec4681e0afc873ef64f4d5bec4393393</originalsourceid><addsrcrecordid>eNp1kElLBDEQhYMoOi4H_4A0eNFDa_Z0jjKuIKPgiMeQyVQ02svY6Ubn3xtt9SBYFBQ8vno8HkK7BB-RNMcO7BGhlLMVNCJMipymWUUjrAXPVaH5BtqM8RljzIQu1tEG5bSQTOkRupk-QQbeg-uyxmexal5C_Zg5iNF2oamztDa0b3aZhdqXtqoGOdTZsukTaWP3VNlskWSou7iN1rwtI-x83y10f342HV_m1zcXV-OT69xxTVnOudREKiG4sAoDnRE_91Rq5oRwGlTKw2VBAFvvCsXAS-75XMySzDRLu4UOBt9F27z2EDtTheigLG0NTR8NEZhzQRVmCd3_gz43fVundImiMjFCfRoeDpRrmxhb8GbRhsq2S0Ow-WzZpJbNV8uJ3ft27GcVzH_Jn1oTcDwAb6GE5f9OZnx28mOZDx8hdvD--2HbFyMVU8I8TC7MKbudqrsJMxP2AUOPlBc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1526270579</pqid></control><display><type>article</type><title>The effect of smoking cessation on airway inflammation in young asthma patients</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Westergaard, C. G. ; Porsbjerg, C. ; Backer, V.</creator><creatorcontrib>Westergaard, C. G. ; Porsbjerg, C. ; Backer, V.</creatorcontrib><description>Summary
Background
Smoking has been shown to have several detrimental effects on asthma, including poor symptom control, attenuated treatment response and accelerated decline in lung function. In spite of this, smoking is at least as common among asthma patients as in the rest of the population. The aggravations of smoking on asthma may be caused by effects on airway inflammation, which has been found to be changed in asthmatic smokers. It is not known whether these smoking‐induced airway inflammation changes are reversible after smoking cessation.
Objective
The aim of this study was to assess airway changes in asthmatic smokers before and during smoking cessation.
Methods
Forty‐six smokers with asthma, all steroid‐free (age range: 19–40), were recruited. All participants attempted smoking cessation over a period of 3 months. Visits were performed at weeks 0, 6 and 12 and included induced sputum, FeNO, methacholine challenge, lung function, Asthma Control Questionnaire (ACQ6) and exhaled CO.
Results
Twenty‐six of 46 patients succeeded in quitting smoking. In the quitters, improvements in methacholine AHR (77% before and 52% after smoking cessation, respectively, P = 0.016) and ACQ6 score (1.7–0.7, P = 0.034) and FeNO (8.7–14.8 p.p.b., P = 0.002) were observed, whereas no significant changes were found regarding eosinophils or lung function. A small but significant decrease in neutrophils (54.1–52%, P = 0.003) was present in quitters compared with the non‐quitters. Non‐quitters experienced no changes in any parameters.
Conclusion
Smoking cessation improved asthma control, but the changes were not related to change in eosinophilic inflammation, and the reduction in neutrophils was small. Thus, airway inflammation with eosinophils and neutrophils may be less important drivers of asthma control in smokers than other factors.
Clinical Relevance
Smoking cessation may improve clinically important disease parameters such as AHR and symptom score, but likely unrelated to changes in airway inflammation.</description><identifier>ISSN: 0954-7894</identifier><identifier>EISSN: 1365-2222</identifier><identifier>DOI: 10.1111/cea.12243</identifier><identifier>PMID: 24286379</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Adult ; airway hyperresponsiveness ; airway inflammation ; asthma ; Asthma - etiology ; Asthma - physiopathology ; Bronchial Provocation Tests ; Exhalation ; Female ; Follow-Up Studies ; Humans ; Immunophenotyping ; Inflammation ; Leukocyte Count ; Leukocytes - immunology ; Leukocytes - metabolism ; Male ; Nitric Oxide ; Respiratory Function Tests ; Risk Factors ; Smoking - adverse effects ; Smoking Cessation ; Sputum - cytology ; Sputum - immunology ; Time Factors ; Young Adult</subject><ispartof>Clinical and experimental allergy, 2014-03, Vol.44 (3), p.353-361</ispartof><rights>2013 John Wiley & Sons Ltd</rights><rights>2013 John Wiley & Sons Ltd.</rights><rights>Copyright © 2014 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4923-44691675545a70e2b1fdf2693c55c9e7fec4681e0afc873ef64f4d5bec4393393</citedby><cites>FETCH-LOGICAL-c4923-44691675545a70e2b1fdf2693c55c9e7fec4681e0afc873ef64f4d5bec4393393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fcea.12243$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fcea.12243$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24286379$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Westergaard, C. G.</creatorcontrib><creatorcontrib>Porsbjerg, C.</creatorcontrib><creatorcontrib>Backer, V.</creatorcontrib><title>The effect of smoking cessation on airway inflammation in young asthma patients</title><title>Clinical and experimental allergy</title><addtitle>Clin Exp Allergy</addtitle><description>Summary
Background
Smoking has been shown to have several detrimental effects on asthma, including poor symptom control, attenuated treatment response and accelerated decline in lung function. In spite of this, smoking is at least as common among asthma patients as in the rest of the population. The aggravations of smoking on asthma may be caused by effects on airway inflammation, which has been found to be changed in asthmatic smokers. It is not known whether these smoking‐induced airway inflammation changes are reversible after smoking cessation.
Objective
The aim of this study was to assess airway changes in asthmatic smokers before and during smoking cessation.
Methods
Forty‐six smokers with asthma, all steroid‐free (age range: 19–40), were recruited. All participants attempted smoking cessation over a period of 3 months. Visits were performed at weeks 0, 6 and 12 and included induced sputum, FeNO, methacholine challenge, lung function, Asthma Control Questionnaire (ACQ6) and exhaled CO.
Results
Twenty‐six of 46 patients succeeded in quitting smoking. In the quitters, improvements in methacholine AHR (77% before and 52% after smoking cessation, respectively, P = 0.016) and ACQ6 score (1.7–0.7, P = 0.034) and FeNO (8.7–14.8 p.p.b., P = 0.002) were observed, whereas no significant changes were found regarding eosinophils or lung function. A small but significant decrease in neutrophils (54.1–52%, P = 0.003) was present in quitters compared with the non‐quitters. Non‐quitters experienced no changes in any parameters.
Conclusion
Smoking cessation improved asthma control, but the changes were not related to change in eosinophilic inflammation, and the reduction in neutrophils was small. Thus, airway inflammation with eosinophils and neutrophils may be less important drivers of asthma control in smokers than other factors.
Clinical Relevance
Smoking cessation may improve clinically important disease parameters such as AHR and symptom score, but likely unrelated to changes in airway inflammation.</description><subject>Adult</subject><subject>airway hyperresponsiveness</subject><subject>airway inflammation</subject><subject>asthma</subject><subject>Asthma - etiology</subject><subject>Asthma - physiopathology</subject><subject>Bronchial Provocation Tests</subject><subject>Exhalation</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Immunophenotyping</subject><subject>Inflammation</subject><subject>Leukocyte Count</subject><subject>Leukocytes - immunology</subject><subject>Leukocytes - metabolism</subject><subject>Male</subject><subject>Nitric Oxide</subject><subject>Respiratory Function Tests</subject><subject>Risk Factors</subject><subject>Smoking - adverse effects</subject><subject>Smoking Cessation</subject><subject>Sputum - cytology</subject><subject>Sputum - immunology</subject><subject>Time Factors</subject><subject>Young Adult</subject><issn>0954-7894</issn><issn>1365-2222</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kElLBDEQhYMoOi4H_4A0eNFDa_Z0jjKuIKPgiMeQyVQ02svY6Ubn3xtt9SBYFBQ8vno8HkK7BB-RNMcO7BGhlLMVNCJMipymWUUjrAXPVaH5BtqM8RljzIQu1tEG5bSQTOkRupk-QQbeg-uyxmexal5C_Zg5iNF2oamztDa0b3aZhdqXtqoGOdTZsukTaWP3VNlskWSou7iN1rwtI-x83y10f342HV_m1zcXV-OT69xxTVnOudREKiG4sAoDnRE_91Rq5oRwGlTKw2VBAFvvCsXAS-75XMySzDRLu4UOBt9F27z2EDtTheigLG0NTR8NEZhzQRVmCd3_gz43fVundImiMjFCfRoeDpRrmxhb8GbRhsq2S0Ow-WzZpJbNV8uJ3ft27GcVzH_Jn1oTcDwAb6GE5f9OZnx28mOZDx8hdvD--2HbFyMVU8I8TC7MKbudqrsJMxP2AUOPlBc</recordid><startdate>201403</startdate><enddate>201403</enddate><creator>Westergaard, C. G.</creator><creator>Porsbjerg, C.</creator><creator>Backer, V.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201403</creationdate><title>The effect of smoking cessation on airway inflammation in young asthma patients</title><author>Westergaard, C. G. ; Porsbjerg, C. ; Backer, V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4923-44691675545a70e2b1fdf2693c55c9e7fec4681e0afc873ef64f4d5bec4393393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>airway hyperresponsiveness</topic><topic>airway inflammation</topic><topic>asthma</topic><topic>Asthma - etiology</topic><topic>Asthma - physiopathology</topic><topic>Bronchial Provocation Tests</topic><topic>Exhalation</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Immunophenotyping</topic><topic>Inflammation</topic><topic>Leukocyte Count</topic><topic>Leukocytes - immunology</topic><topic>Leukocytes - metabolism</topic><topic>Male</topic><topic>Nitric Oxide</topic><topic>Respiratory Function Tests</topic><topic>Risk Factors</topic><topic>Smoking - adverse effects</topic><topic>Smoking Cessation</topic><topic>Sputum - cytology</topic><topic>Sputum - immunology</topic><topic>Time Factors</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Westergaard, C. G.</creatorcontrib><creatorcontrib>Porsbjerg, C.</creatorcontrib><creatorcontrib>Backer, V.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental allergy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Westergaard, C. G.</au><au>Porsbjerg, C.</au><au>Backer, V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of smoking cessation on airway inflammation in young asthma patients</atitle><jtitle>Clinical and experimental allergy</jtitle><addtitle>Clin Exp Allergy</addtitle><date>2014-03</date><risdate>2014</risdate><volume>44</volume><issue>3</issue><spage>353</spage><epage>361</epage><pages>353-361</pages><issn>0954-7894</issn><eissn>1365-2222</eissn><abstract>Summary
Background
Smoking has been shown to have several detrimental effects on asthma, including poor symptom control, attenuated treatment response and accelerated decline in lung function. In spite of this, smoking is at least as common among asthma patients as in the rest of the population. The aggravations of smoking on asthma may be caused by effects on airway inflammation, which has been found to be changed in asthmatic smokers. It is not known whether these smoking‐induced airway inflammation changes are reversible after smoking cessation.
Objective
The aim of this study was to assess airway changes in asthmatic smokers before and during smoking cessation.
Methods
Forty‐six smokers with asthma, all steroid‐free (age range: 19–40), were recruited. All participants attempted smoking cessation over a period of 3 months. Visits were performed at weeks 0, 6 and 12 and included induced sputum, FeNO, methacholine challenge, lung function, Asthma Control Questionnaire (ACQ6) and exhaled CO.
Results
Twenty‐six of 46 patients succeeded in quitting smoking. In the quitters, improvements in methacholine AHR (77% before and 52% after smoking cessation, respectively, P = 0.016) and ACQ6 score (1.7–0.7, P = 0.034) and FeNO (8.7–14.8 p.p.b., P = 0.002) were observed, whereas no significant changes were found regarding eosinophils or lung function. A small but significant decrease in neutrophils (54.1–52%, P = 0.003) was present in quitters compared with the non‐quitters. Non‐quitters experienced no changes in any parameters.
Conclusion
Smoking cessation improved asthma control, but the changes were not related to change in eosinophilic inflammation, and the reduction in neutrophils was small. Thus, airway inflammation with eosinophils and neutrophils may be less important drivers of asthma control in smokers than other factors.
Clinical Relevance
Smoking cessation may improve clinically important disease parameters such as AHR and symptom score, but likely unrelated to changes in airway inflammation.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>24286379</pmid><doi>10.1111/cea.12243</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0954-7894 |
| ispartof | Clinical and experimental allergy, 2014-03, Vol.44 (3), p.353-361 |
| issn | 0954-7894 1365-2222 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1504452703 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult airway hyperresponsiveness airway inflammation asthma Asthma - etiology Asthma - physiopathology Bronchial Provocation Tests Exhalation Female Follow-Up Studies Humans Immunophenotyping Inflammation Leukocyte Count Leukocytes - immunology Leukocytes - metabolism Male Nitric Oxide Respiratory Function Tests Risk Factors Smoking - adverse effects Smoking Cessation Sputum - cytology Sputum - immunology Time Factors Young Adult |
| title | The effect of smoking cessation on airway inflammation in young asthma patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T16%3A28%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20effect%20of%20smoking%20cessation%20on%20airway%20inflammation%20in%20young%20asthma%20patients&rft.jtitle=Clinical%20and%20experimental%20allergy&rft.au=Westergaard,%20C.%20G.&rft.date=2014-03&rft.volume=44&rft.issue=3&rft.spage=353&rft.epage=361&rft.pages=353-361&rft.issn=0954-7894&rft.eissn=1365-2222&rft_id=info:doi/10.1111/cea.12243&rft_dat=%3Cproquest_cross%3E3309976521%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1526270579&rft_id=info:pmid/24286379&rfr_iscdi=true |