Placebo Response in Binge Eating Disorder: A Pooled Analysis of 10 Clinical Trials from One Research Group
ABSTRACT Objective The aim of this study was to gain further understanding of placebo response in binge eating disorder. Method We pooled participant‐level data from 10 double‐blind, placebo‐controlled, randomized trials of medications for binge eating disorder. The primary outcomes were response (7...
Gespeichert in:
| Veröffentlicht in: | European eating disorders review 2014-03, Vol.22 (2), p.140-146 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 146 |
|---|---|
| container_issue | 2 |
| container_start_page | 140 |
| container_title | European eating disorders review |
| container_volume | 22 |
| creator | Blom, Thomas J. Mingione, Carolyn J. Guerdjikova, Anna I. Keck Jr, Paul E. Welge, Jeffrey A. McElroy, Susan L. |
| description | ABSTRACT
Objective
The aim of this study was to gain further understanding of placebo response in binge eating disorder.
Method
We pooled participant‐level data from 10 double‐blind, placebo‐controlled, randomized trials of medications for binge eating disorder. The primary outcomes were response (75% reduction in binge eating episodes), cessation of binge eating episodes, change in mean weekly binge eating episodes and binge eating episodes per week.
Results
Of 234 participants receiving placebo, 89 (38%) were responders and 59 (26%) attained cessation. Placebo‐treated participants significantly reduced their binge eating. The mean (SD) binge eating episodes per week at baseline was 5.2 (3.2) and at endpoint was 2.2 (2.6). Lower baseline binge eating episode frequency and longer study participation were significantly associated with response and cessation.
Discussion
Less severe eating pathology at baseline was associated with higher placebo response and cessation rates. Future clinical trials may want to stipulate that participants exceed a threshold of illness severity, which may lead to better placebo and drug separation. Copyright © 2014 John Wiley & Sons, Ltd and Eating Disorders Association. |
| doi_str_mv | 10.1002/erv.2277 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1504450962</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1504450962</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3877-342e8f12d620b1b2ba664b3499911e52e6e06cae6d515a56d322313702abd8fc3</originalsourceid><addsrcrecordid>eNp1kF1P2zAUQC3ENL4m8QsmS7zsJcwfiR3zVrpSJqFRVd3gzXKSm83FjYvdAP33uKMwaRJP98r36Eg-CB1TckoJYV8hPJwyJuUO2qdEqYwoUe5udsmynHK-hw5inBOS3ovyI9pjOVdpZftoPnGmhsrjKcSl7yJg2-Fz2_0GPDKrNPE3G31oIJzhAZ5476DBg864dbQR-xZTgofOdrY2Ds-CNS7iNvgFvu5g4wQT6j94HHy_PEIf2nSGT9t5iH5ejGbDy-zqevx9OLjKal5KmfGcQdlS1ghGKlqxygiRVzxXSlEKBQMBRNQGRFPQwhSi4YxxyiVhpmrKtuaH6MuLdxn8fQ9xpRc21uCc6cD3UdOC5HmRUrCEnvyHzn0f0u_-UpwyKQT5J6yDjzFAq5fBLkxYa0r0pr9O_fWmf0I_b4V9tYDmDXwNnoDsBXi0DtbvivRo-msr3PI2ruDpjTfhTgvJZaFvfoy1Gs6mEzW71YQ_A1dCmyM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1503127660</pqid></control><display><type>article</type><title>Placebo Response in Binge Eating Disorder: A Pooled Analysis of 10 Clinical Trials from One Research Group</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Blom, Thomas J. ; Mingione, Carolyn J. ; Guerdjikova, Anna I. ; Keck Jr, Paul E. ; Welge, Jeffrey A. ; McElroy, Susan L.</creator><creatorcontrib>Blom, Thomas J. ; Mingione, Carolyn J. ; Guerdjikova, Anna I. ; Keck Jr, Paul E. ; Welge, Jeffrey A. ; McElroy, Susan L.</creatorcontrib><description>ABSTRACT
Objective
The aim of this study was to gain further understanding of placebo response in binge eating disorder.
Method
We pooled participant‐level data from 10 double‐blind, placebo‐controlled, randomized trials of medications for binge eating disorder. The primary outcomes were response (75% reduction in binge eating episodes), cessation of binge eating episodes, change in mean weekly binge eating episodes and binge eating episodes per week.
Results
Of 234 participants receiving placebo, 89 (38%) were responders and 59 (26%) attained cessation. Placebo‐treated participants significantly reduced their binge eating. The mean (SD) binge eating episodes per week at baseline was 5.2 (3.2) and at endpoint was 2.2 (2.6). Lower baseline binge eating episode frequency and longer study participation were significantly associated with response and cessation.
Discussion
Less severe eating pathology at baseline was associated with higher placebo response and cessation rates. Future clinical trials may want to stipulate that participants exceed a threshold of illness severity, which may lead to better placebo and drug separation. Copyright © 2014 John Wiley & Sons, Ltd and Eating Disorders Association.</description><identifier>ISSN: 1072-4133</identifier><identifier>EISSN: 1099-0968</identifier><identifier>DOI: 10.1002/erv.2277</identifier><identifier>PMID: 24399652</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Adult ; binge eating disorder ; Binge-Eating Disorder - diagnosis ; Binge-Eating Disorder - drug therapy ; Binge-Eating Disorder - psychology ; Body Mass Index ; Bulimia ; clinical ; Clinical trials ; Diagnostic and Statistical Manual of Mental Disorders ; Double-Blind Method ; Humans ; Logistic Models ; Medical treatment ; Middle Aged ; Multivariate Analysis ; Odds Ratio ; placebo response ; pooled analysis ; Serotonin Uptake Inhibitors - administration & dosage ; Treatment Outcome ; trial</subject><ispartof>European eating disorders review, 2014-03, Vol.22 (2), p.140-146</ispartof><rights>Copyright © 2014 John Wiley & Sons, Ltd and Eating Disorders Association.</rights><rights>Copyright John Wiley and Sons, Limited Mar 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3877-342e8f12d620b1b2ba664b3499911e52e6e06cae6d515a56d322313702abd8fc3</citedby><cites>FETCH-LOGICAL-c3877-342e8f12d620b1b2ba664b3499911e52e6e06cae6d515a56d322313702abd8fc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Ferv.2277$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Ferv.2277$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24399652$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Blom, Thomas J.</creatorcontrib><creatorcontrib>Mingione, Carolyn J.</creatorcontrib><creatorcontrib>Guerdjikova, Anna I.</creatorcontrib><creatorcontrib>Keck Jr, Paul E.</creatorcontrib><creatorcontrib>Welge, Jeffrey A.</creatorcontrib><creatorcontrib>McElroy, Susan L.</creatorcontrib><title>Placebo Response in Binge Eating Disorder: A Pooled Analysis of 10 Clinical Trials from One Research Group</title><title>European eating disorders review</title><addtitle>Eur. Eat. Disorders Rev</addtitle><description>ABSTRACT
Objective
The aim of this study was to gain further understanding of placebo response in binge eating disorder.
Method
We pooled participant‐level data from 10 double‐blind, placebo‐controlled, randomized trials of medications for binge eating disorder. The primary outcomes were response (75% reduction in binge eating episodes), cessation of binge eating episodes, change in mean weekly binge eating episodes and binge eating episodes per week.
Results
Of 234 participants receiving placebo, 89 (38%) were responders and 59 (26%) attained cessation. Placebo‐treated participants significantly reduced their binge eating. The mean (SD) binge eating episodes per week at baseline was 5.2 (3.2) and at endpoint was 2.2 (2.6). Lower baseline binge eating episode frequency and longer study participation were significantly associated with response and cessation.
Discussion
Less severe eating pathology at baseline was associated with higher placebo response and cessation rates. Future clinical trials may want to stipulate that participants exceed a threshold of illness severity, which may lead to better placebo and drug separation. Copyright © 2014 John Wiley & Sons, Ltd and Eating Disorders Association.</description><subject>Adult</subject><subject>binge eating disorder</subject><subject>Binge-Eating Disorder - diagnosis</subject><subject>Binge-Eating Disorder - drug therapy</subject><subject>Binge-Eating Disorder - psychology</subject><subject>Body Mass Index</subject><subject>Bulimia</subject><subject>clinical</subject><subject>Clinical trials</subject><subject>Diagnostic and Statistical Manual of Mental Disorders</subject><subject>Double-Blind Method</subject><subject>Humans</subject><subject>Logistic Models</subject><subject>Medical treatment</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Odds Ratio</subject><subject>placebo response</subject><subject>pooled analysis</subject><subject>Serotonin Uptake Inhibitors - administration & dosage</subject><subject>Treatment Outcome</subject><subject>trial</subject><issn>1072-4133</issn><issn>1099-0968</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kF1P2zAUQC3ENL4m8QsmS7zsJcwfiR3zVrpSJqFRVd3gzXKSm83FjYvdAP33uKMwaRJP98r36Eg-CB1TckoJYV8hPJwyJuUO2qdEqYwoUe5udsmynHK-hw5inBOS3ovyI9pjOVdpZftoPnGmhsrjKcSl7yJg2-Fz2_0GPDKrNPE3G31oIJzhAZ5476DBg864dbQR-xZTgofOdrY2Ds-CNS7iNvgFvu5g4wQT6j94HHy_PEIf2nSGT9t5iH5ejGbDy-zqevx9OLjKal5KmfGcQdlS1ghGKlqxygiRVzxXSlEKBQMBRNQGRFPQwhSi4YxxyiVhpmrKtuaH6MuLdxn8fQ9xpRc21uCc6cD3UdOC5HmRUrCEnvyHzn0f0u_-UpwyKQT5J6yDjzFAq5fBLkxYa0r0pr9O_fWmf0I_b4V9tYDmDXwNnoDsBXi0DtbvivRo-msr3PI2ruDpjTfhTgvJZaFvfoy1Gs6mEzW71YQ_A1dCmyM</recordid><startdate>201403</startdate><enddate>201403</enddate><creator>Blom, Thomas J.</creator><creator>Mingione, Carolyn J.</creator><creator>Guerdjikova, Anna I.</creator><creator>Keck Jr, Paul E.</creator><creator>Welge, Jeffrey A.</creator><creator>McElroy, Susan L.</creator><general>Blackwell Publishing Ltd</general><general>John Wiley and Sons, Limited</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201403</creationdate><title>Placebo Response in Binge Eating Disorder: A Pooled Analysis of 10 Clinical Trials from One Research Group</title><author>Blom, Thomas J. ; Mingione, Carolyn J. ; Guerdjikova, Anna I. ; Keck Jr, Paul E. ; Welge, Jeffrey A. ; McElroy, Susan L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3877-342e8f12d620b1b2ba664b3499911e52e6e06cae6d515a56d322313702abd8fc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>binge eating disorder</topic><topic>Binge-Eating Disorder - diagnosis</topic><topic>Binge-Eating Disorder - drug therapy</topic><topic>Binge-Eating Disorder - psychology</topic><topic>Body Mass Index</topic><topic>Bulimia</topic><topic>clinical</topic><topic>Clinical trials</topic><topic>Diagnostic and Statistical Manual of Mental Disorders</topic><topic>Double-Blind Method</topic><topic>Humans</topic><topic>Logistic Models</topic><topic>Medical treatment</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Odds Ratio</topic><topic>placebo response</topic><topic>pooled analysis</topic><topic>Serotonin Uptake Inhibitors - administration & dosage</topic><topic>Treatment Outcome</topic><topic>trial</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Blom, Thomas J.</creatorcontrib><creatorcontrib>Mingione, Carolyn J.</creatorcontrib><creatorcontrib>Guerdjikova, Anna I.</creatorcontrib><creatorcontrib>Keck Jr, Paul E.</creatorcontrib><creatorcontrib>Welge, Jeffrey A.</creatorcontrib><creatorcontrib>McElroy, Susan L.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European eating disorders review</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Blom, Thomas J.</au><au>Mingione, Carolyn J.</au><au>Guerdjikova, Anna I.</au><au>Keck Jr, Paul E.</au><au>Welge, Jeffrey A.</au><au>McElroy, Susan L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Placebo Response in Binge Eating Disorder: A Pooled Analysis of 10 Clinical Trials from One Research Group</atitle><jtitle>European eating disorders review</jtitle><addtitle>Eur. Eat. Disorders Rev</addtitle><date>2014-03</date><risdate>2014</risdate><volume>22</volume><issue>2</issue><spage>140</spage><epage>146</epage><pages>140-146</pages><issn>1072-4133</issn><eissn>1099-0968</eissn><abstract>ABSTRACT
Objective
The aim of this study was to gain further understanding of placebo response in binge eating disorder.
Method
We pooled participant‐level data from 10 double‐blind, placebo‐controlled, randomized trials of medications for binge eating disorder. The primary outcomes were response (75% reduction in binge eating episodes), cessation of binge eating episodes, change in mean weekly binge eating episodes and binge eating episodes per week.
Results
Of 234 participants receiving placebo, 89 (38%) were responders and 59 (26%) attained cessation. Placebo‐treated participants significantly reduced their binge eating. The mean (SD) binge eating episodes per week at baseline was 5.2 (3.2) and at endpoint was 2.2 (2.6). Lower baseline binge eating episode frequency and longer study participation were significantly associated with response and cessation.
Discussion
Less severe eating pathology at baseline was associated with higher placebo response and cessation rates. Future clinical trials may want to stipulate that participants exceed a threshold of illness severity, which may lead to better placebo and drug separation. Copyright © 2014 John Wiley & Sons, Ltd and Eating Disorders Association.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>24399652</pmid><doi>10.1002/erv.2277</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1072-4133 |
| ispartof | European eating disorders review, 2014-03, Vol.22 (2), p.140-146 |
| issn | 1072-4133 1099-0968 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1504450962 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult binge eating disorder Binge-Eating Disorder - diagnosis Binge-Eating Disorder - drug therapy Binge-Eating Disorder - psychology Body Mass Index Bulimia clinical Clinical trials Diagnostic and Statistical Manual of Mental Disorders Double-Blind Method Humans Logistic Models Medical treatment Middle Aged Multivariate Analysis Odds Ratio placebo response pooled analysis Serotonin Uptake Inhibitors - administration & dosage Treatment Outcome trial |
| title | Placebo Response in Binge Eating Disorder: A Pooled Analysis of 10 Clinical Trials from One Research Group |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-18T06%3A29%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Placebo%20Response%20in%20Binge%20Eating%20Disorder:%20A%20Pooled%20Analysis%20of%2010%20Clinical%20Trials%20from%20One%20Research%20Group&rft.jtitle=European%20eating%20disorders%20review&rft.au=Blom,%20Thomas%20J.&rft.date=2014-03&rft.volume=22&rft.issue=2&rft.spage=140&rft.epage=146&rft.pages=140-146&rft.issn=1072-4133&rft.eissn=1099-0968&rft_id=info:doi/10.1002/erv.2277&rft_dat=%3Cproquest_cross%3E1504450962%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1503127660&rft_id=info:pmid/24399652&rfr_iscdi=true |