MicroRNA-206 induces G1 arrest in melanoma by inhibition of CDK4 and Cyclin D

Summary Expression profiling of microRNAs in melanoma lesional skin biopsies compared with normal donor skin biopsies, as well as melanoma cell lines compared with normal melanocytes, revealed that hsa‐miR‐206 was down‐regulated in melanoma (−75.4‐fold, P = 1.7 × 10−4). MiR‐206 has been implicated i...

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Veröffentlicht in:	Pigment cell and melanoma research 2014-03, Vol.27 (2), p.275-286
Hauptverfasser:	Georgantas III, Robert W., Streicher, Katie, Luo, Xiaobing, Greenlees, Lydia, Zhu, Wei, Liu, Zheng, Brohawn, Philip, Morehouse, Christopher, Higgs, Brandon W., Richman, Laura, Jallal, Bahija, Yao, Yihong, Ranade, Koustubh
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Base Sequence Biopsy Carcinogenesis - genetics Carcinogenesis - pathology Caspase 3 - metabolism Caspase 7 - metabolism cell cycle cell growth Cell Movement - genetics Cell Proliferation Computational Biology Cyclin D - antagonists & inhibitors Cyclin D - metabolism Cyclin-Dependent Kinase 4 - antagonists & inhibitors Cyclin-Dependent Kinase 4 - metabolism Enzyme Activation G1 arrest G1 Phase Cell Cycle Checkpoints - genetics Gene Expression Regulation, Neoplastic Humans invasion Melanoma - enzymology Melanoma - genetics Melanoma - pathology microRNA MicroRNAs - genetics MicroRNAs - metabolism Middle Aged migration Models, Biological Molecular Sequence Data Neoplasm Invasiveness Protein Biosynthesis Skin Neoplasms - enzymology Skin Neoplasms - genetics Skin Neoplasms - pathology Tissue Donors
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