Low-dose Aspirin and Comorbidities are Significantly Related to Bleeding Peptic Ulcers in Elderly Patients Compared with Nonelderly Patients in Japan
Objective The present study was conducted using data accumulated from our earlier study of bleeding peptic ulcers, focusing on elderly patients. Methods A total of 461 patients with bleeding peptic ulcers underwent emergency endoscopy at Saga Medical School Hospital between 1999 and 2011. Risk facto...
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| Veröffentlicht in: | Internal Medicine 2014, Vol.53(5), pp.367-373 |
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| creator | Higuchi, Toru Iwakiri, Ryuichi Hara, Megumi Shimoda, Ryo Sakata, Yasuhisa Nakayama, Atsushi Nio, Kenta Yamaguchi, Shunsuke Yamaguchi, Daisuke Watanabe, Akira Akutagawa, Takashi Sakata, Hiroyuki Fujimoto, Kazuma |
| description | Objective The present study was conducted using data accumulated from our earlier study of bleeding peptic ulcers, focusing on elderly patients. Methods A total of 461 patients with bleeding peptic ulcers underwent emergency endoscopy at Saga Medical School Hospital between 1999 and 2011. Risk factors for bleeding peptic ulcers were compared between two groups: an elderly group (≥65 years old) and a nonelderly group ( |
| doi_str_mv | 10.2169/internalmedicine.53.0603 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1504165564</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1504165564</sourcerecordid><originalsourceid>FETCH-LOGICAL-c526t-838b25395dd13b29169dc6997ec081f4190ce10482a2cc68ab86be66c8031483</originalsourceid><addsrcrecordid>eNptkctuWyEQhlHVqHHTvkLFspvjcjlgWKZWepOVREm6RhwYO0SYcwpYUR6k71tcp15E3QwLvvlm4EcIUzJnVOpPIVXIycYt-OBCgrngcyIJf4VmlPe6WzAuXqMZ0VR1rJVT9LaUB0K4Wmj2Bp2yXijeMzZDv1fjY-fHAvi8TCGHhG3yeDluxzwEH2qAgm0GfBs2KayDs6nGJ3wD0VbwuI74c4S2RNrga5hqcPhndJALbqKL6CE3-No2S6plb52ay-PHUO_x5ZjgJdG6ftjJpnfoZG1jgffP5xm6-3Jxt_zWra6-fl-erzonmKyd4mpggmvhPeVDe6jU3kmtF-CIouueauKAkl4xy5yTyg5KDiClU4TTXvEz9PGgnfL4awelmm0oDmK0CcZdMVSQnkohZN9QdUBdHkvJsDZTDlubnwwlZp-JeZmJEdzsM2mtH56n7IZ2eWz8F0IDLg_AQ6l2A0fA5vahEf5rFn_LYcIRdPc2G0j8D6RUrBs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1504165564</pqid></control><display><type>article</type><title>Low-dose Aspirin and Comorbidities are Significantly Related to Bleeding Peptic Ulcers in Elderly Patients Compared with Nonelderly Patients in Japan</title><source>J-STAGE Free</source><source>MEDLINE</source><creator>Higuchi, Toru ; Iwakiri, Ryuichi ; Hara, Megumi ; Shimoda, Ryo ; Sakata, Yasuhisa ; Nakayama, Atsushi ; Nio, Kenta ; Yamaguchi, Shunsuke ; Yamaguchi, Daisuke ; Watanabe, Akira ; Akutagawa, Takashi ; Sakata, Hiroyuki ; Fujimoto, Kazuma</creator><creatorcontrib>Higuchi, Toru ; Iwakiri, Ryuichi ; Hara, Megumi ; Shimoda, Ryo ; Sakata, Yasuhisa ; Nakayama, Atsushi ; Nio, Kenta ; Yamaguchi, Shunsuke ; Yamaguchi, Daisuke ; Watanabe, Akira ; Akutagawa, Takashi ; Sakata, Hiroyuki ; Fujimoto, Kazuma</creatorcontrib><description>Objective The present study was conducted using data accumulated from our earlier study of bleeding peptic ulcers, focusing on elderly patients. Methods A total of 461 patients with bleeding peptic ulcers underwent emergency endoscopy at Saga Medical School Hospital between 1999 and 2011. Risk factors for bleeding peptic ulcers were compared between two groups: an elderly group (≥65 years old) and a nonelderly group (<65 years old). The relationship between drug use and age was examined using multiple logistic regression models. In the elderly group, the factors were compared between Period I (1999-2005) and Period II (2006-2011). Results The proportion of men and the incidence of Helicobacter pylori infection were lower in the elderly group than in the nonelderly group. The use of low-dose aspirin, antithrombotic drugs and corticosteroids, but not nonsteroidal anti-inflammatory drugs, was higher in the elderly group. A multiple logistic regression analysis of prescribed medications indicated that low-dose aspirin was more frequently used in the elderly group. The rate of comorbidities was higher and the hemoglobin levels were lower in the elderly group. The rates of rebleeding within one week and death within one month did not differ in the elderly group. Compared with that observed in Period I, the incidence of Helicobacter pylori infection was decreased and the rate of comorbidities was increased in Period II. Conclusion This study indicates that factors related to bleeding peptic ulcers in elderly patients have shifted from Helicobacter pylori infection to comorbidities associated with low-dose aspirin, suggesting a close relationship between low-dose aspirin therapy and comorbidities in elderly patients with peptic ulcers.</description><identifier>ISSN: 0918-2918</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.53.0603</identifier><identifier>PMID: 24583422</identifier><language>eng</language><publisher>Japan: The Japanese Society of Internal Medicine</publisher><subject>Adolescent ; Adult ; Age Distribution ; Age Factors ; Aged ; Aged, 80 and over ; Anti-Inflammatory Agents, Non-Steroidal - administration & dosage ; Anti-Inflammatory Agents, Non-Steroidal - adverse effects ; antithrombotic drugs ; Aspirin - administration & dosage ; Aspirin - adverse effects ; Comorbidity ; corticosteroids ; Dose-Response Relationship, Drug ; Endoscopy, Gastrointestinal ; Female ; Follow-Up Studies ; Helicobacter Infections - epidemiology ; Helicobacter Infections - microbiology ; Helicobacter pylori ; Helicobacter pylori - isolation & purification ; hemostasis ; Humans ; Incidence ; Japan - epidemiology ; Male ; Middle Aged ; nonsteroidal anti-inflammatory drugs ; Peptic Ulcer Hemorrhage - diagnosis ; Peptic Ulcer Hemorrhage - epidemiology ; Retrospective Studies ; Risk Factors ; Stomach Ulcer - diagnosis ; Stomach Ulcer - epidemiology ; Stomach Ulcer - microbiology ; Young Adult</subject><ispartof>Internal Medicine, 2014, Vol.53(5), pp.367-373</ispartof><rights>2014 by The Japanese Society of Internal Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-838b25395dd13b29169dc6997ec081f4190ce10482a2cc68ab86be66c8031483</citedby><cites>FETCH-LOGICAL-c526t-838b25395dd13b29169dc6997ec081f4190ce10482a2cc68ab86be66c8031483</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,1885,27931,27932</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24583422$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Higuchi, Toru</creatorcontrib><creatorcontrib>Iwakiri, Ryuichi</creatorcontrib><creatorcontrib>Hara, Megumi</creatorcontrib><creatorcontrib>Shimoda, Ryo</creatorcontrib><creatorcontrib>Sakata, Yasuhisa</creatorcontrib><creatorcontrib>Nakayama, Atsushi</creatorcontrib><creatorcontrib>Nio, Kenta</creatorcontrib><creatorcontrib>Yamaguchi, Shunsuke</creatorcontrib><creatorcontrib>Yamaguchi, Daisuke</creatorcontrib><creatorcontrib>Watanabe, Akira</creatorcontrib><creatorcontrib>Akutagawa, Takashi</creatorcontrib><creatorcontrib>Sakata, Hiroyuki</creatorcontrib><creatorcontrib>Fujimoto, Kazuma</creatorcontrib><title>Low-dose Aspirin and Comorbidities are Significantly Related to Bleeding Peptic Ulcers in Elderly Patients Compared with Nonelderly Patients in Japan</title><title>Internal Medicine</title><addtitle>Intern. Med.</addtitle><description>Objective The present study was conducted using data accumulated from our earlier study of bleeding peptic ulcers, focusing on elderly patients. Methods A total of 461 patients with bleeding peptic ulcers underwent emergency endoscopy at Saga Medical School Hospital between 1999 and 2011. Risk factors for bleeding peptic ulcers were compared between two groups: an elderly group (≥65 years old) and a nonelderly group (<65 years old). The relationship between drug use and age was examined using multiple logistic regression models. In the elderly group, the factors were compared between Period I (1999-2005) and Period II (2006-2011). Results The proportion of men and the incidence of Helicobacter pylori infection were lower in the elderly group than in the nonelderly group. The use of low-dose aspirin, antithrombotic drugs and corticosteroids, but not nonsteroidal anti-inflammatory drugs, was higher in the elderly group. A multiple logistic regression analysis of prescribed medications indicated that low-dose aspirin was more frequently used in the elderly group. The rate of comorbidities was higher and the hemoglobin levels were lower in the elderly group. The rates of rebleeding within one week and death within one month did not differ in the elderly group. Compared with that observed in Period I, the incidence of Helicobacter pylori infection was decreased and the rate of comorbidities was increased in Period II. Conclusion This study indicates that factors related to bleeding peptic ulcers in elderly patients have shifted from Helicobacter pylori infection to comorbidities associated with low-dose aspirin, suggesting a close relationship between low-dose aspirin therapy and comorbidities in elderly patients with peptic ulcers.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Distribution</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - administration & dosage</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - adverse effects</subject><subject>antithrombotic drugs</subject><subject>Aspirin - administration & dosage</subject><subject>Aspirin - adverse effects</subject><subject>Comorbidity</subject><subject>corticosteroids</subject><subject>Dose-Response Relationship, Drug</subject><subject>Endoscopy, Gastrointestinal</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Helicobacter Infections - epidemiology</subject><subject>Helicobacter Infections - microbiology</subject><subject>Helicobacter pylori</subject><subject>Helicobacter pylori - isolation & purification</subject><subject>hemostasis</subject><subject>Humans</subject><subject>Incidence</subject><subject>Japan - epidemiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>nonsteroidal anti-inflammatory drugs</subject><subject>Peptic Ulcer Hemorrhage - diagnosis</subject><subject>Peptic Ulcer Hemorrhage - epidemiology</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Stomach Ulcer - diagnosis</subject><subject>Stomach Ulcer - epidemiology</subject><subject>Stomach Ulcer - microbiology</subject><subject>Young Adult</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkctuWyEQhlHVqHHTvkLFspvjcjlgWKZWepOVREm6RhwYO0SYcwpYUR6k71tcp15E3QwLvvlm4EcIUzJnVOpPIVXIycYt-OBCgrngcyIJf4VmlPe6WzAuXqMZ0VR1rJVT9LaUB0K4Wmj2Bp2yXijeMzZDv1fjY-fHAvi8TCGHhG3yeDluxzwEH2qAgm0GfBs2KayDs6nGJ3wD0VbwuI74c4S2RNrga5hqcPhndJALbqKL6CE3-No2S6plb52ay-PHUO_x5ZjgJdG6ftjJpnfoZG1jgffP5xm6-3Jxt_zWra6-fl-erzonmKyd4mpggmvhPeVDe6jU3kmtF-CIouueauKAkl4xy5yTyg5KDiClU4TTXvEz9PGgnfL4awelmm0oDmK0CcZdMVSQnkohZN9QdUBdHkvJsDZTDlubnwwlZp-JeZmJEdzsM2mtH56n7IZ2eWz8F0IDLg_AQ6l2A0fA5vahEf5rFn_LYcIRdPc2G0j8D6RUrBs</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Higuchi, Toru</creator><creator>Iwakiri, Ryuichi</creator><creator>Hara, Megumi</creator><creator>Shimoda, Ryo</creator><creator>Sakata, Yasuhisa</creator><creator>Nakayama, Atsushi</creator><creator>Nio, Kenta</creator><creator>Yamaguchi, Shunsuke</creator><creator>Yamaguchi, Daisuke</creator><creator>Watanabe, Akira</creator><creator>Akutagawa, Takashi</creator><creator>Sakata, Hiroyuki</creator><creator>Fujimoto, Kazuma</creator><general>The Japanese Society of Internal Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140101</creationdate><title>Low-dose Aspirin and Comorbidities are Significantly Related to Bleeding Peptic Ulcers in Elderly Patients Compared with Nonelderly Patients in Japan</title><author>Higuchi, Toru ; Iwakiri, Ryuichi ; Hara, Megumi ; Shimoda, Ryo ; Sakata, Yasuhisa ; Nakayama, Atsushi ; Nio, Kenta ; Yamaguchi, Shunsuke ; Yamaguchi, Daisuke ; Watanabe, Akira ; Akutagawa, Takashi ; Sakata, Hiroyuki ; Fujimoto, Kazuma</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526t-838b25395dd13b29169dc6997ec081f4190ce10482a2cc68ab86be66c8031483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age Distribution</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - administration & dosage</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - adverse effects</topic><topic>antithrombotic drugs</topic><topic>Aspirin - administration & dosage</topic><topic>Aspirin - adverse effects</topic><topic>Comorbidity</topic><topic>corticosteroids</topic><topic>Dose-Response Relationship, Drug</topic><topic>Endoscopy, Gastrointestinal</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Helicobacter Infections - epidemiology</topic><topic>Helicobacter Infections - microbiology</topic><topic>Helicobacter pylori</topic><topic>Helicobacter pylori - isolation & purification</topic><topic>hemostasis</topic><topic>Humans</topic><topic>Incidence</topic><topic>Japan - epidemiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>nonsteroidal anti-inflammatory drugs</topic><topic>Peptic Ulcer Hemorrhage - diagnosis</topic><topic>Peptic Ulcer Hemorrhage - epidemiology</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Stomach Ulcer - diagnosis</topic><topic>Stomach Ulcer - epidemiology</topic><topic>Stomach Ulcer - microbiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Higuchi, Toru</creatorcontrib><creatorcontrib>Iwakiri, Ryuichi</creatorcontrib><creatorcontrib>Hara, Megumi</creatorcontrib><creatorcontrib>Shimoda, Ryo</creatorcontrib><creatorcontrib>Sakata, Yasuhisa</creatorcontrib><creatorcontrib>Nakayama, Atsushi</creatorcontrib><creatorcontrib>Nio, Kenta</creatorcontrib><creatorcontrib>Yamaguchi, Shunsuke</creatorcontrib><creatorcontrib>Yamaguchi, Daisuke</creatorcontrib><creatorcontrib>Watanabe, Akira</creatorcontrib><creatorcontrib>Akutagawa, Takashi</creatorcontrib><creatorcontrib>Sakata, Hiroyuki</creatorcontrib><creatorcontrib>Fujimoto, Kazuma</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Higuchi, Toru</au><au>Iwakiri, Ryuichi</au><au>Hara, Megumi</au><au>Shimoda, Ryo</au><au>Sakata, Yasuhisa</au><au>Nakayama, Atsushi</au><au>Nio, Kenta</au><au>Yamaguchi, Shunsuke</au><au>Yamaguchi, Daisuke</au><au>Watanabe, Akira</au><au>Akutagawa, Takashi</au><au>Sakata, Hiroyuki</au><au>Fujimoto, Kazuma</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low-dose Aspirin and Comorbidities are Significantly Related to Bleeding Peptic Ulcers in Elderly Patients Compared with Nonelderly Patients in Japan</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. Med.</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>53</volume><issue>5</issue><spage>367</spage><epage>373</epage><pages>367-373</pages><issn>0918-2918</issn><eissn>1349-7235</eissn><abstract>Objective The present study was conducted using data accumulated from our earlier study of bleeding peptic ulcers, focusing on elderly patients. Methods A total of 461 patients with bleeding peptic ulcers underwent emergency endoscopy at Saga Medical School Hospital between 1999 and 2011. Risk factors for bleeding peptic ulcers were compared between two groups: an elderly group (≥65 years old) and a nonelderly group (<65 years old). The relationship between drug use and age was examined using multiple logistic regression models. In the elderly group, the factors were compared between Period I (1999-2005) and Period II (2006-2011). Results The proportion of men and the incidence of Helicobacter pylori infection were lower in the elderly group than in the nonelderly group. The use of low-dose aspirin, antithrombotic drugs and corticosteroids, but not nonsteroidal anti-inflammatory drugs, was higher in the elderly group. A multiple logistic regression analysis of prescribed medications indicated that low-dose aspirin was more frequently used in the elderly group. The rate of comorbidities was higher and the hemoglobin levels were lower in the elderly group. The rates of rebleeding within one week and death within one month did not differ in the elderly group. Compared with that observed in Period I, the incidence of Helicobacter pylori infection was decreased and the rate of comorbidities was increased in Period II. Conclusion This study indicates that factors related to bleeding peptic ulcers in elderly patients have shifted from Helicobacter pylori infection to comorbidities associated with low-dose aspirin, suggesting a close relationship between low-dose aspirin therapy and comorbidities in elderly patients with peptic ulcers.</abstract><cop>Japan</cop><pub>The Japanese Society of Internal Medicine</pub><pmid>24583422</pmid><doi>10.2169/internalmedicine.53.0603</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Age Distribution Age Factors Aged Aged, 80 and over Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - adverse effects antithrombotic drugs Aspirin - administration & dosage Aspirin - adverse effects Comorbidity corticosteroids Dose-Response Relationship, Drug Endoscopy, Gastrointestinal Female Follow-Up Studies Helicobacter Infections - epidemiology Helicobacter Infections - microbiology Helicobacter pylori Helicobacter pylori - isolation & purification hemostasis Humans Incidence Japan - epidemiology Male Middle Aged nonsteroidal anti-inflammatory drugs Peptic Ulcer Hemorrhage - diagnosis Peptic Ulcer Hemorrhage - epidemiology Retrospective Studies Risk Factors Stomach Ulcer - diagnosis Stomach Ulcer - epidemiology Stomach Ulcer - microbiology Young Adult |
| title | Low-dose Aspirin and Comorbidities are Significantly Related to Bleeding Peptic Ulcers in Elderly Patients Compared with Nonelderly Patients in Japan |
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