Development of a recombinant antibody towards PAPP-A for immunohistochemical use in multiple animal species

The metalloproteinase, pregnancy-associated plasma protein-A (PAPP-A), is increasingly recognized as a modulator of insulin-like growth factor (IGF) signaling; it cleaves IGF binding proteins causing the release of bioactive IGF. Accumulating evidence supports an important role of PAPP-A in both nor...

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Veröffentlicht in:	Journal of immunological methods 2014-02, Vol.404, p.33-40
Hauptverfasser:	Mikkelsen, Jakob H., Steffensen, Lasse B., Oxvig, Claus
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity maturation Amino Acid Sequence Animals Antibody Affinity Antibody Specificity Conserved Sequence Epitopes - chemistry Epitopes - immunology Female Formaldehyde Humans Immunoglobulin G - biosynthesis Immunoglobulin G - immunology Immunohistochemistry Immunohistochemistry - methods Mice Molecular Sequence Data Paraffin Embedding Pregnancy Pregnancy-Associated Plasma Protein-A - analysis Pregnancy-Associated Plasma Protein-A - immunology Pregnancy-associated plasma-protein-A Recombinant antibody Recombinant Proteins - biosynthesis Recombinant Proteins - immunology Sequence Alignment Single-Chain Antibodies - biosynthesis Single-Chain Antibodies - immunology Swine Tissue Fixation
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