Magnetic resonance spectroscopy imaging-directed transrectal ultrasound biopsy increases prostate cancer detection in men with prostate-specific antigen between 4-10 ng/mL and normal digital rectal examination
Objectives To evaluate the ability of magnetic resonance spectroscopic imaging to improve prostate cancer detection rate. Methods A retrospective analysis was carried out of 278 men with prostate‐specific antigen in the range of 4–10 ng/mL and normal digital rectal examination who underwent transrec...
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| Veröffentlicht in: | International journal of urology 2014-03, Vol.21 (3), p.257-262 |
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| container_title | International journal of urology |
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| creator | Javali, Tarun Dilip Dwivedi, Durgesh Kumar Kumar, Rajeev Jagannathan, Naranamangalam Raghunathan Thulkar, Sanjay Dinda, Amit Kumar |
| description | Objectives
To evaluate the ability of magnetic resonance spectroscopic imaging to improve prostate cancer detection rate.
Methods
A retrospective analysis was carried out of 278 men with prostate‐specific antigen in the range of 4–10 ng/mL and normal digital rectal examination who underwent transrectal ultrasound‐guided prostate biopsy. Outcomes were compared between men who had a standard biopsy versus those who also underwent a prebiopsy magnetic resonance spectroscopic imaging. Men with an abnormal voxel on magnetic resonance spectroscopic imaging had standard transrectal ultrasound biopsies plus biopsies directed to the abnormal voxels.
Results
The study group (n = 140) and control group (n = 138) were similar in baseline parameters, such as mean age, prostate size and mean prostate‐specific antigen. The overall cancer detection in the magnetic resonance spectroscopic imaging positive group (24.4%) was more than double that of the control group (10.1%). On comparing the magnetic resonance spectroscopic imaging results with the transrectal ultrasound biopsy findings, magnetic resonance spectroscopic imaging had 95.6% sensitivity, 41.9% specificity, a positive predictive value of 24.4%, a negative predictive value of 98% and an accuracy of 51.4%.
Conclusions
Magnetic resonance spectroscopic imaging‐directed transrectal ultrasound biopsy increases the cancer detection rate compared with standard transrectal ultrasound biopsy in patients with normal digital rectal examination and elevated prostate‐specific antigen in the range of 4–10 ng/mL. |
| doi_str_mv | 10.1111/iju.12258 |
| format | Article |
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To evaluate the ability of magnetic resonance spectroscopic imaging to improve prostate cancer detection rate.
Methods
A retrospective analysis was carried out of 278 men with prostate‐specific antigen in the range of 4–10 ng/mL and normal digital rectal examination who underwent transrectal ultrasound‐guided prostate biopsy. Outcomes were compared between men who had a standard biopsy versus those who also underwent a prebiopsy magnetic resonance spectroscopic imaging. Men with an abnormal voxel on magnetic resonance spectroscopic imaging had standard transrectal ultrasound biopsies plus biopsies directed to the abnormal voxels.
Results
The study group (n = 140) and control group (n = 138) were similar in baseline parameters, such as mean age, prostate size and mean prostate‐specific antigen. The overall cancer detection in the magnetic resonance spectroscopic imaging positive group (24.4%) was more than double that of the control group (10.1%). On comparing the magnetic resonance spectroscopic imaging results with the transrectal ultrasound biopsy findings, magnetic resonance spectroscopic imaging had 95.6% sensitivity, 41.9% specificity, a positive predictive value of 24.4%, a negative predictive value of 98% and an accuracy of 51.4%.
Conclusions
Magnetic resonance spectroscopic imaging‐directed transrectal ultrasound biopsy increases the cancer detection rate compared with standard transrectal ultrasound biopsy in patients with normal digital rectal examination and elevated prostate‐specific antigen in the range of 4–10 ng/mL.</description><identifier>ISSN: 0919-8172</identifier><identifier>EISSN: 1442-2042</identifier><identifier>DOI: 10.1111/iju.12258</identifier><identifier>PMID: 23980749</identifier><language>eng</language><publisher>Australia: Blackwell Publishing Ltd</publisher><subject>Digital Rectal Examination ; Endoscopic Ultrasound-Guided Fine Needle Aspiration - methods ; Humans ; magnetic resonance spectroscopic imaging ; Magnetic Resonance Spectroscopy ; Male ; Middle Aged ; prostate cancer ; Prostate-Specific Antigen - blood ; Prostatic Neoplasms - blood ; Prostatic Neoplasms - pathology ; Retrospective Studies ; transrectal ultrasound-guided biopsy</subject><ispartof>International journal of urology, 2014-03, Vol.21 (3), p.257-262</ispartof><rights>2013 The Japanese Urological Association</rights><rights>2013 The Japanese Urological Association.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3178-8b1d7955ddbab36b566b3e5c26db18193197e3937c09f31a8d9d9b6aa64388fe3</citedby><cites>FETCH-LOGICAL-c3178-8b1d7955ddbab36b566b3e5c26db18193197e3937c09f31a8d9d9b6aa64388fe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fiju.12258$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fiju.12258$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23980749$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Javali, Tarun Dilip</creatorcontrib><creatorcontrib>Dwivedi, Durgesh Kumar</creatorcontrib><creatorcontrib>Kumar, Rajeev</creatorcontrib><creatorcontrib>Jagannathan, Naranamangalam Raghunathan</creatorcontrib><creatorcontrib>Thulkar, Sanjay</creatorcontrib><creatorcontrib>Dinda, Amit Kumar</creatorcontrib><title>Magnetic resonance spectroscopy imaging-directed transrectal ultrasound biopsy increases prostate cancer detection in men with prostate-specific antigen between 4-10 ng/mL and normal digital rectal examination</title><title>International journal of urology</title><addtitle>Int J Urol</addtitle><description>Objectives
To evaluate the ability of magnetic resonance spectroscopic imaging to improve prostate cancer detection rate.
Methods
A retrospective analysis was carried out of 278 men with prostate‐specific antigen in the range of 4–10 ng/mL and normal digital rectal examination who underwent transrectal ultrasound‐guided prostate biopsy. Outcomes were compared between men who had a standard biopsy versus those who also underwent a prebiopsy magnetic resonance spectroscopic imaging. Men with an abnormal voxel on magnetic resonance spectroscopic imaging had standard transrectal ultrasound biopsies plus biopsies directed to the abnormal voxels.
Results
The study group (n = 140) and control group (n = 138) were similar in baseline parameters, such as mean age, prostate size and mean prostate‐specific antigen. The overall cancer detection in the magnetic resonance spectroscopic imaging positive group (24.4%) was more than double that of the control group (10.1%). On comparing the magnetic resonance spectroscopic imaging results with the transrectal ultrasound biopsy findings, magnetic resonance spectroscopic imaging had 95.6% sensitivity, 41.9% specificity, a positive predictive value of 24.4%, a negative predictive value of 98% and an accuracy of 51.4%.
Conclusions
Magnetic resonance spectroscopic imaging‐directed transrectal ultrasound biopsy increases the cancer detection rate compared with standard transrectal ultrasound biopsy in patients with normal digital rectal examination and elevated prostate‐specific antigen in the range of 4–10 ng/mL.</description><subject>Digital Rectal Examination</subject><subject>Endoscopic Ultrasound-Guided Fine Needle Aspiration - methods</subject><subject>Humans</subject><subject>magnetic resonance spectroscopic imaging</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>prostate cancer</subject><subject>Prostate-Specific Antigen - blood</subject><subject>Prostatic Neoplasms - blood</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Retrospective Studies</subject><subject>transrectal ultrasound-guided biopsy</subject><issn>0919-8172</issn><issn>1442-2042</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1u1DAQxyMEokvhwAsgH-GQbhznwz7CAm3R8iFBBTfLsWeDS-IE29F2b73yfLwBT8KE3e4NX8b2_OY_X0nylGZnFM_SXk9nNM9Lfi9Z0KLI0zwr8vvJIhNUpJzW-UnyKITrLKMsp_xhcpIzwbO6EIvk93vVOohWEw9hcMppIGEEHf0Q9DDuiO1Va12bGuvxFwyJXrkw31VHpg5fYZicIY0dxoC40x5UgEBGVIgqAtGzqCcGIgbZwSFDenBka-P3I5XOSe0G61Au2hbdDcQtoC1Smv25_eXaZb9GpyFu8D3mNra1cw2HUuBG9dapOcHj5MFGdQGeHOxpcvX2zZfVRbr-eH65erlONaM1T3lDTS3K0phGNaxqyqpqGJQ6r0xDORWMihqYYLXOxIZRxY0woqmUqgrG-QbYafJ8r4tN_JwgRNnboKHrlINhCpKWWUGrvOAloi_2qMZ-cXobOXqcrN9Jmsl5hxJ3KP_tENlnB9mp6cEcybulIbDcA1vbwe7_SvLy3dWdZLqPsCHCzTFC-R-yqlldyq8fzuXq9advr0T1GRP9BQq3vFQ</recordid><startdate>201403</startdate><enddate>201403</enddate><creator>Javali, Tarun Dilip</creator><creator>Dwivedi, Durgesh Kumar</creator><creator>Kumar, Rajeev</creator><creator>Jagannathan, Naranamangalam Raghunathan</creator><creator>Thulkar, Sanjay</creator><creator>Dinda, Amit Kumar</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201403</creationdate><title>Magnetic resonance spectroscopy imaging-directed transrectal ultrasound biopsy increases prostate cancer detection in men with prostate-specific antigen between 4-10 ng/mL and normal digital rectal examination</title><author>Javali, Tarun Dilip ; Dwivedi, Durgesh Kumar ; Kumar, Rajeev ; Jagannathan, Naranamangalam Raghunathan ; Thulkar, Sanjay ; Dinda, Amit Kumar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3178-8b1d7955ddbab36b566b3e5c26db18193197e3937c09f31a8d9d9b6aa64388fe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Digital Rectal Examination</topic><topic>Endoscopic Ultrasound-Guided Fine Needle Aspiration - methods</topic><topic>Humans</topic><topic>magnetic resonance spectroscopic imaging</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>prostate cancer</topic><topic>Prostate-Specific Antigen - blood</topic><topic>Prostatic Neoplasms - blood</topic><topic>Prostatic Neoplasms - pathology</topic><topic>Retrospective Studies</topic><topic>transrectal ultrasound-guided biopsy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Javali, Tarun Dilip</creatorcontrib><creatorcontrib>Dwivedi, Durgesh Kumar</creatorcontrib><creatorcontrib>Kumar, Rajeev</creatorcontrib><creatorcontrib>Jagannathan, Naranamangalam Raghunathan</creatorcontrib><creatorcontrib>Thulkar, Sanjay</creatorcontrib><creatorcontrib>Dinda, Amit Kumar</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of urology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Javali, Tarun Dilip</au><au>Dwivedi, Durgesh Kumar</au><au>Kumar, Rajeev</au><au>Jagannathan, Naranamangalam Raghunathan</au><au>Thulkar, Sanjay</au><au>Dinda, Amit Kumar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Magnetic resonance spectroscopy imaging-directed transrectal ultrasound biopsy increases prostate cancer detection in men with prostate-specific antigen between 4-10 ng/mL and normal digital rectal examination</atitle><jtitle>International journal of urology</jtitle><addtitle>Int J Urol</addtitle><date>2014-03</date><risdate>2014</risdate><volume>21</volume><issue>3</issue><spage>257</spage><epage>262</epage><pages>257-262</pages><issn>0919-8172</issn><eissn>1442-2042</eissn><abstract>Objectives
To evaluate the ability of magnetic resonance spectroscopic imaging to improve prostate cancer detection rate.
Methods
A retrospective analysis was carried out of 278 men with prostate‐specific antigen in the range of 4–10 ng/mL and normal digital rectal examination who underwent transrectal ultrasound‐guided prostate biopsy. Outcomes were compared between men who had a standard biopsy versus those who also underwent a prebiopsy magnetic resonance spectroscopic imaging. Men with an abnormal voxel on magnetic resonance spectroscopic imaging had standard transrectal ultrasound biopsies plus biopsies directed to the abnormal voxels.
Results
The study group (n = 140) and control group (n = 138) were similar in baseline parameters, such as mean age, prostate size and mean prostate‐specific antigen. The overall cancer detection in the magnetic resonance spectroscopic imaging positive group (24.4%) was more than double that of the control group (10.1%). On comparing the magnetic resonance spectroscopic imaging results with the transrectal ultrasound biopsy findings, magnetic resonance spectroscopic imaging had 95.6% sensitivity, 41.9% specificity, a positive predictive value of 24.4%, a negative predictive value of 98% and an accuracy of 51.4%.
Conclusions
Magnetic resonance spectroscopic imaging‐directed transrectal ultrasound biopsy increases the cancer detection rate compared with standard transrectal ultrasound biopsy in patients with normal digital rectal examination and elevated prostate‐specific antigen in the range of 4–10 ng/mL.</abstract><cop>Australia</cop><pub>Blackwell Publishing Ltd</pub><pmid>23980749</pmid><doi>10.1111/iju.12258</doi><tpages>6</tpages></addata></record> |
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| ispartof | International journal of urology, 2014-03, Vol.21 (3), p.257-262 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Digital Rectal Examination Endoscopic Ultrasound-Guided Fine Needle Aspiration - methods Humans magnetic resonance spectroscopic imaging Magnetic Resonance Spectroscopy Male Middle Aged prostate cancer Prostate-Specific Antigen - blood Prostatic Neoplasms - blood Prostatic Neoplasms - pathology Retrospective Studies transrectal ultrasound-guided biopsy |
| title | Magnetic resonance spectroscopy imaging-directed transrectal ultrasound biopsy increases prostate cancer detection in men with prostate-specific antigen between 4-10 ng/mL and normal digital rectal examination |
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