Detection and severity grading of COPD exacerbations using the exacerbations of chronic pulmonary disease tool (EXACT)
Uncertainty exists over the ability of the exacerbations of chronic pulmonary disease tool (EXACT) patient-reported outcome diary to quantify exacerbation severity and frequency. To clarify this, we investigated the ability of the EXACT to assess severity of exacerbations and examined the relationsh...
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| Veröffentlicht in: | The European respiratory journal 2014-03, Vol.43 (3), p.735-744 |
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| container_title | The European respiratory journal |
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| creator | MACKAY, Alex J DONALDSON, Gavin C PATEL, Anant R. C SINGH, Richa KOWLESSAR, Beverly WEDZICHA, Jadwiga A |
| description | Uncertainty exists over the ability of the exacerbations of chronic pulmonary disease tool (EXACT) patient-reported outcome diary to quantify exacerbation severity and frequency. To clarify this, we investigated the ability of the EXACT to assess severity of exacerbations and examined the relationship between exacerbations diagnosed using London chronic obstructive pulmonary disease (COPD) cohort diary cards, physician review and symptom-defined events using the EXACT. 58 patients enrolled in the London Chronic Obstructive Pulmonary Disease (COPD) cohort prospectively completed the EXACT during 128 cohort diary card-defined exacerbations between January 2010 and April 2012. Mean ± sd EXACT scores increased from 42.6 ± 8.6 at baseline to 48.0 ± 8.6 at exacerbation onset (p |
| doi_str_mv | 10.1183/09031936.00110913 |
| format | Article |
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Mean ± sd EXACT scores increased from 42.6 ± 8.6 at baseline to 48.0 ± 8.6 at exacerbation onset (p<0.001), and rose further to a maximum score of 54.1 ± 8.9. Maximum EXACT scores were significantly higher in treated than untreated events. Time taken for EXACT scores to return to baseline was significantly related to symptom recovery time as judged by London COPD cohort diary cards, and to peak expiratory flow rate recovery. ∼50% of both diary card-defined and healthcare utilisation exacerbations crossed the EXACT event threshold. However, only 27.9% of diary card-defined and 34.6% of healthcare utilisation exacerbations fully met the criteria for an EXACT event. Patients exhibited smaller rises in the EXACT score at exacerbation as baseline disease severity increased. The EXACT is an effective method of evaluating chronic obstructive pulmonary disease exacerbation severity. However, concerns remain about the ability of the EXACT to accurately detect exacerbations.</description><identifier>ISSN: 0903-1936</identifier><identifier>EISSN: 1399-3003</identifier><identifier>DOI: 10.1183/09031936.00110913</identifier><identifier>PMID: 23988767</identifier><language>eng</language><publisher>Leeds: Maney</publisher><subject>Aged ; Biological and medical sciences ; Chronic obstructive pulmonary disease, asthma ; Cohort Studies ; Disease Progression ; Female ; Forced Expiratory Volume ; Humans ; Inflammation ; Lung - physiopathology ; Male ; Medical sciences ; Middle Aged ; Outpatients ; Patient Participation ; Peak Expiratory Flow Rate ; Pneumology ; Pulmonary Disease, Chronic Obstructive - diagnosis ; Pulmonary Disease, Chronic Obstructive - physiopathology ; Severity of Illness Index ; Time Factors ; Treatment Outcome</subject><ispartof>The European respiratory journal, 2014-03, Vol.43 (3), p.735-744</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c440t-4cbdcd635ff1f1c6adab584f3e6291a9e020de07c75f0120c3407a9457d790363</citedby><cites>FETCH-LOGICAL-c440t-4cbdcd635ff1f1c6adab584f3e6291a9e020de07c75f0120c3407a9457d790363</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28203714$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23988767$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MACKAY, Alex J</creatorcontrib><creatorcontrib>DONALDSON, Gavin C</creatorcontrib><creatorcontrib>PATEL, Anant R. 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To clarify this, we investigated the ability of the EXACT to assess severity of exacerbations and examined the relationship between exacerbations diagnosed using London chronic obstructive pulmonary disease (COPD) cohort diary cards, physician review and symptom-defined events using the EXACT. 58 patients enrolled in the London Chronic Obstructive Pulmonary Disease (COPD) cohort prospectively completed the EXACT during 128 cohort diary card-defined exacerbations between January 2010 and April 2012. Mean ± sd EXACT scores increased from 42.6 ± 8.6 at baseline to 48.0 ± 8.6 at exacerbation onset (p<0.001), and rose further to a maximum score of 54.1 ± 8.9. Maximum EXACT scores were significantly higher in treated than untreated events. Time taken for EXACT scores to return to baseline was significantly related to symptom recovery time as judged by London COPD cohort diary cards, and to peak expiratory flow rate recovery. ∼50% of both diary card-defined and healthcare utilisation exacerbations crossed the EXACT event threshold. However, only 27.9% of diary card-defined and 34.6% of healthcare utilisation exacerbations fully met the criteria for an EXACT event. Patients exhibited smaller rises in the EXACT score at exacerbation as baseline disease severity increased. The EXACT is an effective method of evaluating chronic obstructive pulmonary disease exacerbation severity. However, concerns remain about the ability of the EXACT to accurately detect exacerbations.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Chronic obstructive pulmonary disease, asthma</subject><subject>Cohort Studies</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Forced Expiratory Volume</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Lung - physiopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Outpatients</subject><subject>Patient Participation</subject><subject>Peak Expiratory Flow Rate</subject><subject>Pneumology</subject><subject>Pulmonary Disease, Chronic Obstructive - diagnosis</subject><subject>Pulmonary Disease, Chronic Obstructive - physiopathology</subject><subject>Severity of Illness Index</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><issn>0903-1936</issn><issn>1399-3003</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0E1LxDAQBuAgiq4fP8CL5CLooTrTpB85yvoJgh4UvJVsMtFKt1mTdtF_b4u7Cp4CmecdmJexQ4QzxFKcgwKBSuRnAIigUGywCQqlEgEgNtlknCcj2GG7Mb4PKpcCt9lOKlRZFnkxYctL6sh0tW-5bi2PtKRQd1_8NWhbt6_cOz59eLzk9KkNhZkeZeR9HGfdG_37H7R5C76tDV_0zdy3OnxxW0fSkXjnfcNPrl4upk-n-2zL6SbSwerdY8_XV0_T2-T-4eZuenGfGCmhS6SZWWNzkTmHDk2urZ5lpXSC8lShVgQpWILCFJkDTMEICYVWMitsMdyeiz128rN3EfxHT7Gr5nU01DS6Jd_HCjOQKLMhMVD8oSb4GAO5ahHq-XBAhVCNdVfruqt13UPmaLW-n83J_ibW_Q7geAV0NLpxQbemjn-uTEEUKMU30tSHgw</recordid><startdate>20140301</startdate><enddate>20140301</enddate><creator>MACKAY, Alex J</creator><creator>DONALDSON, Gavin C</creator><creator>PATEL, Anant R. 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C</creatorcontrib><creatorcontrib>SINGH, Richa</creatorcontrib><creatorcontrib>KOWLESSAR, Beverly</creatorcontrib><creatorcontrib>WEDZICHA, Jadwiga A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The European respiratory journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MACKAY, Alex J</au><au>DONALDSON, Gavin C</au><au>PATEL, Anant R. 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To clarify this, we investigated the ability of the EXACT to assess severity of exacerbations and examined the relationship between exacerbations diagnosed using London chronic obstructive pulmonary disease (COPD) cohort diary cards, physician review and symptom-defined events using the EXACT. 58 patients enrolled in the London Chronic Obstructive Pulmonary Disease (COPD) cohort prospectively completed the EXACT during 128 cohort diary card-defined exacerbations between January 2010 and April 2012. Mean ± sd EXACT scores increased from 42.6 ± 8.6 at baseline to 48.0 ± 8.6 at exacerbation onset (p<0.001), and rose further to a maximum score of 54.1 ± 8.9. Maximum EXACT scores were significantly higher in treated than untreated events. Time taken for EXACT scores to return to baseline was significantly related to symptom recovery time as judged by London COPD cohort diary cards, and to peak expiratory flow rate recovery. ∼50% of both diary card-defined and healthcare utilisation exacerbations crossed the EXACT event threshold. However, only 27.9% of diary card-defined and 34.6% of healthcare utilisation exacerbations fully met the criteria for an EXACT event. Patients exhibited smaller rises in the EXACT score at exacerbation as baseline disease severity increased. The EXACT is an effective method of evaluating chronic obstructive pulmonary disease exacerbation severity. However, concerns remain about the ability of the EXACT to accurately detect exacerbations.</abstract><cop>Leeds</cop><pub>Maney</pub><pmid>23988767</pmid><doi>10.1183/09031936.00110913</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Biological and medical sciences Chronic obstructive pulmonary disease, asthma Cohort Studies Disease Progression Female Forced Expiratory Volume Humans Inflammation Lung - physiopathology Male Medical sciences Middle Aged Outpatients Patient Participation Peak Expiratory Flow Rate Pneumology Pulmonary Disease, Chronic Obstructive - diagnosis Pulmonary Disease, Chronic Obstructive - physiopathology Severity of Illness Index Time Factors Treatment Outcome |
| title | Detection and severity grading of COPD exacerbations using the exacerbations of chronic pulmonary disease tool (EXACT) |
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