Longitudinal assessment in COPD patients: multidimensional variability and outcomes
The value and timing of multidimensional assessments in chronic obstructive pulmonary disease (COPD) remains unclear because there is little information about their variability and relationship to outcome. The aim of this study was to determine the progression of COPD using clinical and spirometric...
Gespeichert in:
| Veröffentlicht in: | The European respiratory journal 2014-03, Vol.43 (3), p.745-753 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 753 |
|---|---|
| container_issue | 3 |
| container_start_page | 745 |
| container_title | The European respiratory journal |
| container_volume | 43 |
| creator | CASANOVA, Ciro AGUIRRE-JAIME, Armando CELLI, Bartolomé R DE TORRES, Juan P PINTO-PLATA, Victor BAZ, Rebeca MARIN, Jose M DIVO, Miguel CORDOBA, Elizabeth BASALDUA, Santiago COTE, Claudia |
| description | The value and timing of multidimensional assessments in chronic obstructive pulmonary disease (COPD) remains unclear because there is little information about their variability and relationship to outcome. The aim of this study was to determine the progression of COPD using clinical and spirometric variability over time with mortality as the outcome. We determined the annual intra-individual variability of forced expiratory volume in 1 s (FEV1) and BODE (body mass index, airflow obstruction, dyspnoea, exercise capacity) index in 403 patients with at least five measurements. The pattern was defined as "stable" if the annual change remained constant in ≥66% of the observations and "unstable" if it did not meet that threshold. We explored the minimum number of yearly observations that related to mortality in the 704 patients of the cohort. The "unstable" pattern of FEV1 was seen in 53% and 40% of patients using a threshold of 40 mL·year(-1) and 100 mL·year(-1), respectively. There was a slightly more "stable" pattern in the BODE index (62% for 1 point). A profile associated with mortality was defined by a baseline measurement followed by annual measurements for 2 years of the BODE index, but not its individual components, including FEV1 (p |
| doi_str_mv | 10.1183/09031936.00096913 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1504143485</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1504143485</sourcerecordid><originalsourceid>FETCH-LOGICAL-c374t-5a44b4662f98ea3725956dff85fdde8b7fc90d95c1e97a719a0c1e52201ffa583</originalsourceid><addsrcrecordid>eNpFkE1Lw0AQhhdRbK3-AC-Si-AlOpPdTbLepH5CoYJ6DtNkV1byUTOJ0H9vQls9zQzv887hEeIc4RoxlTdgQKKR8TUAmNigPBBTlMaEEkAeiumYhyMwESfMXwAYK4nHYhIpSKIIYSreFk396bu-8DWVATFb5srWXeDrYL58vQ_W1Pnh5tug6svOF35I2Tcj_UOtp5UvfbcJqC6Cpu_yprJ8Ko4clWzPdnMmPh4f3ufP4WL59DK_W4S5TFQXalJqpeI4cia1JJNIGx0XzqXaFYVNV4nLDRRG52hNQgkagmHVUQToHOlUzsTV9u-6bb57y11Wec5tWVJtm54z1KBQSZXqAcUtmrcNc2tdtm59Re0mQ8hGl9neZbZ3OXQudu_7VWWLv8Ze3gBc7gDinErXUp17_ufSCGSCWv4CoP98Jw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1504143485</pqid></control><display><type>article</type><title>Longitudinal assessment in COPD patients: multidimensional variability and outcomes</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>CASANOVA, Ciro ; AGUIRRE-JAIME, Armando ; CELLI, Bartolomé R ; DE TORRES, Juan P ; PINTO-PLATA, Victor ; BAZ, Rebeca ; MARIN, Jose M ; DIVO, Miguel ; CORDOBA, Elizabeth ; BASALDUA, Santiago ; COTE, Claudia</creator><creatorcontrib>CASANOVA, Ciro ; AGUIRRE-JAIME, Armando ; CELLI, Bartolomé R ; DE TORRES, Juan P ; PINTO-PLATA, Victor ; BAZ, Rebeca ; MARIN, Jose M ; DIVO, Miguel ; CORDOBA, Elizabeth ; BASALDUA, Santiago ; COTE, Claudia</creatorcontrib><description>The value and timing of multidimensional assessments in chronic obstructive pulmonary disease (COPD) remains unclear because there is little information about their variability and relationship to outcome. The aim of this study was to determine the progression of COPD using clinical and spirometric variability over time with mortality as the outcome. We determined the annual intra-individual variability of forced expiratory volume in 1 s (FEV1) and BODE (body mass index, airflow obstruction, dyspnoea, exercise capacity) index in 403 patients with at least five measurements. The pattern was defined as "stable" if the annual change remained constant in ≥66% of the observations and "unstable" if it did not meet that threshold. We explored the minimum number of yearly observations that related to mortality in the 704 patients of the cohort. The "unstable" pattern of FEV1 was seen in 53% and 40% of patients using a threshold of 40 mL·year(-1) and 100 mL·year(-1), respectively. There was a slightly more "stable" pattern in the BODE index (62% for 1 point). A profile associated with mortality was defined by a baseline measurement followed by annual measurements for 2 years of the BODE index, but not its individual components, including FEV1 (p<0.001). Progression of COPD measured using FEV1 is inconsistent and relates poorly to outcome. Monitoring the more stable BODE index better assesses disease progression.</description><identifier>ISSN: 0903-1936</identifier><identifier>EISSN: 1399-3003</identifier><identifier>DOI: 10.1183/09031936.00096913</identifier><identifier>PMID: 24072210</identifier><language>eng</language><publisher>Leeds: Maney</publisher><subject>Aged ; Algorithms ; Biological and medical sciences ; Body Mass Index ; Chronic obstructive pulmonary disease, asthma ; Disease Progression ; Dyspnea - physiopathology ; Exercise Tolerance ; Female ; Forced Expiratory Volume ; Humans ; Longitudinal Studies ; Male ; Medical sciences ; Middle Aged ; Pneumology ; Pulmonary Disease, Chronic Obstructive - diagnosis ; Pulmonary Disease, Chronic Obstructive - mortality ; Pulmonary Disease, Chronic Obstructive - physiopathology ; Reproducibility of Results ; Respiratory Function Tests ; Risk ; Severity of Illness Index ; Spirometry - methods ; Time Factors ; Treatment Outcome</subject><ispartof>The European respiratory journal, 2014-03, Vol.43 (3), p.745-753</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c374t-5a44b4662f98ea3725956dff85fdde8b7fc90d95c1e97a719a0c1e52201ffa583</citedby><cites>FETCH-LOGICAL-c374t-5a44b4662f98ea3725956dff85fdde8b7fc90d95c1e97a719a0c1e52201ffa583</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27911,27912</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28203715$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24072210$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CASANOVA, Ciro</creatorcontrib><creatorcontrib>AGUIRRE-JAIME, Armando</creatorcontrib><creatorcontrib>CELLI, Bartolomé R</creatorcontrib><creatorcontrib>DE TORRES, Juan P</creatorcontrib><creatorcontrib>PINTO-PLATA, Victor</creatorcontrib><creatorcontrib>BAZ, Rebeca</creatorcontrib><creatorcontrib>MARIN, Jose M</creatorcontrib><creatorcontrib>DIVO, Miguel</creatorcontrib><creatorcontrib>CORDOBA, Elizabeth</creatorcontrib><creatorcontrib>BASALDUA, Santiago</creatorcontrib><creatorcontrib>COTE, Claudia</creatorcontrib><title>Longitudinal assessment in COPD patients: multidimensional variability and outcomes</title><title>The European respiratory journal</title><addtitle>Eur Respir J</addtitle><description>The value and timing of multidimensional assessments in chronic obstructive pulmonary disease (COPD) remains unclear because there is little information about their variability and relationship to outcome. The aim of this study was to determine the progression of COPD using clinical and spirometric variability over time with mortality as the outcome. We determined the annual intra-individual variability of forced expiratory volume in 1 s (FEV1) and BODE (body mass index, airflow obstruction, dyspnoea, exercise capacity) index in 403 patients with at least five measurements. The pattern was defined as "stable" if the annual change remained constant in ≥66% of the observations and "unstable" if it did not meet that threshold. We explored the minimum number of yearly observations that related to mortality in the 704 patients of the cohort. The "unstable" pattern of FEV1 was seen in 53% and 40% of patients using a threshold of 40 mL·year(-1) and 100 mL·year(-1), respectively. There was a slightly more "stable" pattern in the BODE index (62% for 1 point). A profile associated with mortality was defined by a baseline measurement followed by annual measurements for 2 years of the BODE index, but not its individual components, including FEV1 (p<0.001). Progression of COPD measured using FEV1 is inconsistent and relates poorly to outcome. Monitoring the more stable BODE index better assesses disease progression.</description><subject>Aged</subject><subject>Algorithms</subject><subject>Biological and medical sciences</subject><subject>Body Mass Index</subject><subject>Chronic obstructive pulmonary disease, asthma</subject><subject>Disease Progression</subject><subject>Dyspnea - physiopathology</subject><subject>Exercise Tolerance</subject><subject>Female</subject><subject>Forced Expiratory Volume</subject><subject>Humans</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pneumology</subject><subject>Pulmonary Disease, Chronic Obstructive - diagnosis</subject><subject>Pulmonary Disease, Chronic Obstructive - mortality</subject><subject>Pulmonary Disease, Chronic Obstructive - physiopathology</subject><subject>Reproducibility of Results</subject><subject>Respiratory Function Tests</subject><subject>Risk</subject><subject>Severity of Illness Index</subject><subject>Spirometry - methods</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><issn>0903-1936</issn><issn>1399-3003</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1Lw0AQhhdRbK3-AC-Si-AlOpPdTbLepH5CoYJ6DtNkV1byUTOJ0H9vQls9zQzv887hEeIc4RoxlTdgQKKR8TUAmNigPBBTlMaEEkAeiumYhyMwESfMXwAYK4nHYhIpSKIIYSreFk396bu-8DWVATFb5srWXeDrYL58vQ_W1Pnh5tug6svOF35I2Tcj_UOtp5UvfbcJqC6Cpu_yprJ8Ko4clWzPdnMmPh4f3ufP4WL59DK_W4S5TFQXalJqpeI4cia1JJNIGx0XzqXaFYVNV4nLDRRG52hNQgkagmHVUQToHOlUzsTV9u-6bb57y11Wec5tWVJtm54z1KBQSZXqAcUtmrcNc2tdtm59Re0mQ8hGl9neZbZ3OXQudu_7VWWLv8Ze3gBc7gDinErXUp17_ufSCGSCWv4CoP98Jw</recordid><startdate>20140301</startdate><enddate>20140301</enddate><creator>CASANOVA, Ciro</creator><creator>AGUIRRE-JAIME, Armando</creator><creator>CELLI, Bartolomé R</creator><creator>DE TORRES, Juan P</creator><creator>PINTO-PLATA, Victor</creator><creator>BAZ, Rebeca</creator><creator>MARIN, Jose M</creator><creator>DIVO, Miguel</creator><creator>CORDOBA, Elizabeth</creator><creator>BASALDUA, Santiago</creator><creator>COTE, Claudia</creator><general>Maney</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140301</creationdate><title>Longitudinal assessment in COPD patients: multidimensional variability and outcomes</title><author>CASANOVA, Ciro ; AGUIRRE-JAIME, Armando ; CELLI, Bartolomé R ; DE TORRES, Juan P ; PINTO-PLATA, Victor ; BAZ, Rebeca ; MARIN, Jose M ; DIVO, Miguel ; CORDOBA, Elizabeth ; BASALDUA, Santiago ; COTE, Claudia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c374t-5a44b4662f98ea3725956dff85fdde8b7fc90d95c1e97a719a0c1e52201ffa583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Algorithms</topic><topic>Biological and medical sciences</topic><topic>Body Mass Index</topic><topic>Chronic obstructive pulmonary disease, asthma</topic><topic>Disease Progression</topic><topic>Dyspnea - physiopathology</topic><topic>Exercise Tolerance</topic><topic>Female</topic><topic>Forced Expiratory Volume</topic><topic>Humans</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pneumology</topic><topic>Pulmonary Disease, Chronic Obstructive - diagnosis</topic><topic>Pulmonary Disease, Chronic Obstructive - mortality</topic><topic>Pulmonary Disease, Chronic Obstructive - physiopathology</topic><topic>Reproducibility of Results</topic><topic>Respiratory Function Tests</topic><topic>Risk</topic><topic>Severity of Illness Index</topic><topic>Spirometry - methods</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CASANOVA, Ciro</creatorcontrib><creatorcontrib>AGUIRRE-JAIME, Armando</creatorcontrib><creatorcontrib>CELLI, Bartolomé R</creatorcontrib><creatorcontrib>DE TORRES, Juan P</creatorcontrib><creatorcontrib>PINTO-PLATA, Victor</creatorcontrib><creatorcontrib>BAZ, Rebeca</creatorcontrib><creatorcontrib>MARIN, Jose M</creatorcontrib><creatorcontrib>DIVO, Miguel</creatorcontrib><creatorcontrib>CORDOBA, Elizabeth</creatorcontrib><creatorcontrib>BASALDUA, Santiago</creatorcontrib><creatorcontrib>COTE, Claudia</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The European respiratory journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CASANOVA, Ciro</au><au>AGUIRRE-JAIME, Armando</au><au>CELLI, Bartolomé R</au><au>DE TORRES, Juan P</au><au>PINTO-PLATA, Victor</au><au>BAZ, Rebeca</au><au>MARIN, Jose M</au><au>DIVO, Miguel</au><au>CORDOBA, Elizabeth</au><au>BASALDUA, Santiago</au><au>COTE, Claudia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Longitudinal assessment in COPD patients: multidimensional variability and outcomes</atitle><jtitle>The European respiratory journal</jtitle><addtitle>Eur Respir J</addtitle><date>2014-03-01</date><risdate>2014</risdate><volume>43</volume><issue>3</issue><spage>745</spage><epage>753</epage><pages>745-753</pages><issn>0903-1936</issn><eissn>1399-3003</eissn><abstract>The value and timing of multidimensional assessments in chronic obstructive pulmonary disease (COPD) remains unclear because there is little information about their variability and relationship to outcome. The aim of this study was to determine the progression of COPD using clinical and spirometric variability over time with mortality as the outcome. We determined the annual intra-individual variability of forced expiratory volume in 1 s (FEV1) and BODE (body mass index, airflow obstruction, dyspnoea, exercise capacity) index in 403 patients with at least five measurements. The pattern was defined as "stable" if the annual change remained constant in ≥66% of the observations and "unstable" if it did not meet that threshold. We explored the minimum number of yearly observations that related to mortality in the 704 patients of the cohort. The "unstable" pattern of FEV1 was seen in 53% and 40% of patients using a threshold of 40 mL·year(-1) and 100 mL·year(-1), respectively. There was a slightly more "stable" pattern in the BODE index (62% for 1 point). A profile associated with mortality was defined by a baseline measurement followed by annual measurements for 2 years of the BODE index, but not its individual components, including FEV1 (p<0.001). Progression of COPD measured using FEV1 is inconsistent and relates poorly to outcome. Monitoring the more stable BODE index better assesses disease progression.</abstract><cop>Leeds</cop><pub>Maney</pub><pmid>24072210</pmid><doi>10.1183/09031936.00096913</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0903-1936 |
| ispartof | The European respiratory journal, 2014-03, Vol.43 (3), p.745-753 |
| issn | 0903-1936 1399-3003 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1504143485 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Aged Algorithms Biological and medical sciences Body Mass Index Chronic obstructive pulmonary disease, asthma Disease Progression Dyspnea - physiopathology Exercise Tolerance Female Forced Expiratory Volume Humans Longitudinal Studies Male Medical sciences Middle Aged Pneumology Pulmonary Disease, Chronic Obstructive - diagnosis Pulmonary Disease, Chronic Obstructive - mortality Pulmonary Disease, Chronic Obstructive - physiopathology Reproducibility of Results Respiratory Function Tests Risk Severity of Illness Index Spirometry - methods Time Factors Treatment Outcome |
| title | Longitudinal assessment in COPD patients: multidimensional variability and outcomes |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T19%3A16%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Longitudinal%20assessment%20in%20COPD%20patients:%20multidimensional%20variability%20and%20outcomes&rft.jtitle=The%20European%20respiratory%20journal&rft.au=CASANOVA,%20Ciro&rft.date=2014-03-01&rft.volume=43&rft.issue=3&rft.spage=745&rft.epage=753&rft.pages=745-753&rft.issn=0903-1936&rft.eissn=1399-3003&rft_id=info:doi/10.1183/09031936.00096913&rft_dat=%3Cproquest_cross%3E1504143485%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1504143485&rft_id=info:pmid/24072210&rfr_iscdi=true |