Synthesis and evaluation of the antimicrobial activities of 3-((5-phenyl-1,3,4-oxadiazol-2-yl)methyl)-2-thioxothiazolidin-4-one derivatives

Two novel series of 3-((5-phenyl-1,3,4-oxadiazol-2-yl)methyl)-2-thioxothiazolidin-4-one derivatives were designed and synthesized, and their anti-bacterial activities evaluated. These compounds showed broad-spectrum inhibitory activities against both Gram-positive and Gram-negative bacteria with min...

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Veröffentlicht in:	European journal of medicinal chemistry 2014-03, Vol.74, p.405-410
Hauptverfasser:	Liu, Jia-Chun, Zheng, Chang-Ji, Wang, Meng-Xiao, Li, Ya-Ru, Ma, Long-xu, Hou, Shao-Pu, Piao, Hu-Ri
Format:	Artikel
Sprache:	eng
Schlagworte:	1,3,4-Oxadiazole 2-Thioxothiazolidin-4-one Anti-Infective Agents - chemical synthesis Anti-Infective Agents - pharmacology Antibacterial activity Magnetic Resonance Spectroscopy Microbial Sensitivity Tests Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Spectrophotometry, Infrared Thiazolidines - chemical synthesis Thiazolidines - pharmacology
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