Longitudinal analysis of the electroencephalogram and sleep phenotype in the R6/2 mouse model of Huntington's disease

Deficits in sleep and circadian organization have been identified as common early features in patients with Huntington's disease that correlate with symptom severity and may be instrumental in disease progression. Studies in Huntington's disease gene carriers suggest that alterations in th...

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Veröffentlicht in:	Brain (London, England : 1878) England : 1878), 2013-07, Vol.136 (Pt 7), p.2159-2172
Hauptverfasser:	FISHER, Simon P, BLACK, Sarah W, SCHWARTZ, Michael D, WILK, Alan J, CHEN, Tsui-Ming, LINCOLN, Webster U, LIU, Helen W, KILDUFF, Thomas S, MORAIRTY, Stephen R
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Biological and medical sciences Body Temperature - genetics Brain Waves - genetics Brain Waves - physiology Circadian Rhythm - genetics Circadian Rhythm - physiology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease Models, Animal Disease Progression Electroencephalography Electromyography Humans Huntingtin Protein Huntington Disease - complications Huntington Disease - genetics Longitudinal Studies Male Medical sciences Mice Mice, Inbred C57BL Mice, Transgenic Motor Activity - genetics Nerve Tissue Proteins - genetics Neurology Phenotype Sleep Deprivation - physiopathology Sleep Stages - genetics Sleep Stages - physiology Sleep Wake Disorders - etiology Spectrum Analysis Trinucleotide Repeats - genetics Wakefulness - genetics
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