Resolution of streptozotocin-induced diabetes mellitus by pancreatic transplantation in inbred mice
Streptozotocin (SZ), an antineoplastic antibiotic, is a nitrosurea derived from Streptomyces achromogenes and is known to be specifically toxic to the beta cell of the islets of Langerhans in the mammalian pancreas. In this report the authors demonstrate that the hyperglycemia induced by treatment w...
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| Veröffentlicht in: | Transplantation 1988-10, Vol.46 (4), p.611-613 |
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| container_title | Transplantation |
| container_volume | 46 |
| creator | Pollak, R Blanchard, J M Welsh, T |
| description | Streptozotocin (SZ), an antineoplastic antibiotic, is a nitrosurea derived from Streptomyces achromogenes and is known to be specifically toxic to the beta cell of the islets of Langerhans in the mammalian pancreas. In this report the authors demonstrate that the hyperglycemia induced by treatment with low-dose SZ in mice of intermediate sensitivity is curable by the transplantation of an MHC-compatible pancreas, using a technique not previously described. The data suggest that the induction of hyperglycemia in these strains is a result of SZ-mediated cytotoxicity rather than an immunologically mediated phenomenon. |
| doi_str_mv | 10.1097/00007890-198810000-00037 |
| format | Article |
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The data suggest that the induction of hyperglycemia in these strains is a result of SZ-mediated cytotoxicity rather than an immunologically mediated phenomenon.</description><identifier>ISSN: 0041-1337</identifier><identifier>DOI: 10.1097/00007890-198810000-00037</identifier><identifier>PMID: 2972096</identifier><language>eng</language><publisher>United States</publisher><subject>Animals ; Diabetes Mellitus, Experimental - chemically induced ; Diabetes Mellitus, Experimental - therapy ; Hyperglycemia - therapy ; Mice ; Mice, Inbred BALB C - physiology ; Pancreas Transplantation ; Streptozocin</subject><ispartof>Transplantation, 1988-10, Vol.46 (4), p.611-613</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c273t-3bed5c985511cea51c693648ddad3d643c0449f5151fafffbfd7ccbcd5316b523</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27926,27927</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2972096$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pollak, R</creatorcontrib><creatorcontrib>Blanchard, J M</creatorcontrib><creatorcontrib>Welsh, T</creatorcontrib><title>Resolution of streptozotocin-induced diabetes mellitus by pancreatic transplantation in inbred mice</title><title>Transplantation</title><addtitle>Transplantation</addtitle><description>Streptozotocin (SZ), an antineoplastic antibiotic, is a nitrosurea derived from Streptomyces achromogenes and is known to be specifically toxic to the beta cell of the islets of Langerhans in the mammalian pancreas. In this report the authors demonstrate that the hyperglycemia induced by treatment with low-dose SZ in mice of intermediate sensitivity is curable by the transplantation of an MHC-compatible pancreas, using a technique not previously described. The data suggest that the induction of hyperglycemia in these strains is a result of SZ-mediated cytotoxicity rather than an immunologically mediated phenomenon.</description><subject>Animals</subject><subject>Diabetes Mellitus, Experimental - chemically induced</subject><subject>Diabetes Mellitus, Experimental - therapy</subject><subject>Hyperglycemia - therapy</subject><subject>Mice</subject><subject>Mice, Inbred BALB C - physiology</subject><subject>Pancreas Transplantation</subject><subject>Streptozocin</subject><issn>0041-1337</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1PwzAMhnMAjTH4CUg9cSskS9M0RzTxJU1CQnCOEieRgtqmJOlh_HqyMWbZsmz5ta0HoYrgO4IFv8fFeCdwTUTXkX1Vl6D8DC0xbkhNKOUX6DKlr9JmlPMFWqwFX2PRLhG82xT6OfswVsFVKUc75fATcgA_1n40M1hTGa-0zTZVg-17n-dU6V01qRGiVdlDlaMa09SrMavDJr93HYty8GCv0LlTfbLXx7xCn0-PH5uXevv2_Lp52Naw5jTXVFvDQHSMEQJWMQKtoG3TGaMMNW1DATeNcIww4pRzTjvDATQYRkmr2Zqu0O3f3imG79mmLAefoHysRhvmJAkrVHiLy2D3NwgxpBStk1P0g4o7SbDcM5X_TOWJqTwwLdKb441ZD9achEeg9BeaOHcS</recordid><startdate>19881001</startdate><enddate>19881001</enddate><creator>Pollak, R</creator><creator>Blanchard, J M</creator><creator>Welsh, T</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>19881001</creationdate><title>Resolution of streptozotocin-induced diabetes mellitus by pancreatic transplantation in inbred mice</title><author>Pollak, R ; Blanchard, J M ; Welsh, T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c273t-3bed5c985511cea51c693648ddad3d643c0449f5151fafffbfd7ccbcd5316b523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Animals</topic><topic>Diabetes Mellitus, Experimental - chemically induced</topic><topic>Diabetes Mellitus, Experimental - therapy</topic><topic>Hyperglycemia - therapy</topic><topic>Mice</topic><topic>Mice, Inbred BALB C - physiology</topic><topic>Pancreas Transplantation</topic><topic>Streptozocin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pollak, R</creatorcontrib><creatorcontrib>Blanchard, J M</creatorcontrib><creatorcontrib>Welsh, T</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pollak, R</au><au>Blanchard, J M</au><au>Welsh, T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Resolution of streptozotocin-induced diabetes mellitus by pancreatic transplantation in inbred mice</atitle><jtitle>Transplantation</jtitle><addtitle>Transplantation</addtitle><date>1988-10-01</date><risdate>1988</risdate><volume>46</volume><issue>4</issue><spage>611</spage><epage>613</epage><pages>611-613</pages><issn>0041-1337</issn><abstract>Streptozotocin (SZ), an antineoplastic antibiotic, is a nitrosurea derived from Streptomyces achromogenes and is known to be specifically toxic to the beta cell of the islets of Langerhans in the mammalian pancreas. 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| fulltext | fulltext |
| identifier | ISSN: 0041-1337 |
| ispartof | Transplantation, 1988-10, Vol.46 (4), p.611-613 |
| issn | 0041-1337 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Animals Diabetes Mellitus, Experimental - chemically induced Diabetes Mellitus, Experimental - therapy Hyperglycemia - therapy Mice Mice, Inbred BALB C - physiology Pancreas Transplantation Streptozocin |
| title | Resolution of streptozotocin-induced diabetes mellitus by pancreatic transplantation in inbred mice |
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