Novel evidence for the specific interaction between cholesterol and α-haemolysin of Escherichia coli

Several toxins that act on animal cells present different, but specific, interactions with cholesterol or sphingomyelin. In the present study we demonstrate that HlyA (α-haemolysin) of Escherichia coli interacts directly with cholesterol. We have recently reported that HlyA became associated with de...

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Veröffentlicht in:	Biochemical journal 2014-03, Vol.458 (3), p.481-489
Hauptverfasser:	Vazquez, Romina F, Maté, Sabina M, Bakás, Laura S, Fernández, Marisa M, Malchiodi, Emilio L, Herlax, Vanesa S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cholesterol - chemistry Cholesterol - metabolism Escherichia coli Proteins - chemistry Escherichia coli Proteins - metabolism Hemolysin Proteins - chemistry Hemolysin Proteins - metabolism Hemolysis In Vitro Techniques Sheep Sphingomyelins - chemistry Sphingomyelins - metabolism Surface Plasmon Resonance Unilamellar Liposomes - chemistry
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