Simultaneous determination of four alkaloids in mice plasma and brain by LC–MS/MS for pharmacokinetic studies after administration of Corydalis Rhizoma and Yuanhu Zhitong extracts

•Simultaneous determination of four alkaloids in mice plasma and brain by LC–MS/MS.•We compared the pharmacokinetic profiles between CR and CR–ADR.•ADR affected the pharmacokinetic behavior of CR.•The four monitored alkaloids could pass through the blood brain barrier in vivo. A sensitive and select...

Ausführliche Beschreibung