Anti-TNF antibody-induced psoriasiform skin lesions in patients with inflammatory bowel disease are characterised by interferon-γ-expressing Th1 cells and IL-17A/IL-22-expressing Th17 cells and respond to anti-IL-12/IL-23 antibody treatment

Background We analysed incidence, predictors, histological features and specific treatment options of anti-tumour necrosis factor α (TNF-α) antibody-induced psoriasiform skin lesions in patients with inflammatory bowel diseases (IBD). Design Patients with IBD were prospectively screened for anti-TNF...

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Veröffentlicht in:	Gut 2014-04, Vol.63 (4), p.567-577
Hauptverfasser:	Tillack, Cornelia, Ehmann, Laura Maximiliane, Friedrich, Matthias, Laubender, Rüdiger P, Papay, Pavol, Vogelsang, Harald, Stallhofer, Johannes, Beigel, Florian, Bedynek, Andrea, Wetzke, Martin, Maier, Harald, Koburger, Maria, Wagner, Johanna, Glas, Jürgen, Diegelmann, Julia, Koglin, Sarah, Dombrowski, Yvonne, Schauber, Jürgen, Wollenberg, Andreas, Brand, Stephan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antibodies - immunology Antibodies - therapeutic use Antibodies, Monoclonal, Humanized - immunology Antibodies, Monoclonal, Humanized - therapeutic use Female Humans Inflammatory Bowel Diseases - complications Inflammatory Bowel Diseases - immunology Inflammatory Bowel Diseases - pathology Inflammatory Bowel Diseases - physiopathology Interferon-gamma - immunology Interferon-gamma - physiology Interleukin-12 - immunology Interleukin-12 - physiology Interleukin-17 - immunology Interleukin-17 - physiology Interleukin-22 Interleukin-23 - immunology Interleukin-23 - physiology Interleukins - immunology Interleukins - physiology Male Prospective Studies Psoriasis - etiology Psoriasis - immunology Psoriasis - physiopathology Skin - immunology Skin - pathology Skin - physiopathology Th1 Cells - immunology Th1 Cells - physiology Tumor Necrosis Factor-alpha - immunology Tumor Necrosis Factor-alpha - physiology Ustekinumab
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