Antioxidant profile in patients with complex regional pain syndrome type I
Objective Complex regional pain syndrome (CRPS) type I is one of the most important problems with regard to physical medicine and rehabilitation. CRPS may cause not only higher therapeutic costs but also greater work time loss. The mechanism and pathogenesis of CRPS still remains unknown. Some findi...
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| Veröffentlicht in: | International journal of rheumatic diseases 2014-02, Vol.17 (2), p.156-158 |
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| container_title | International journal of rheumatic diseases |
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| creator | Baykal, Tuba Seferoglu, Buminhan Karsan, Orhan Kiziltunc, Ahmet Senel, Kazim |
| description | Objective
Complex regional pain syndrome (CRPS) type I is one of the most important problems with regard to physical medicine and rehabilitation. CRPS may cause not only higher therapeutic costs but also greater work time loss. The mechanism and pathogenesis of CRPS still remains unknown. Some findings indicating oxidative stress have been reported. This study was carried out to determine the role of oxidative stress in patients with CRPS.
Materials and methods
Twenty patients (13 women and seven men) with CRPS and 20 age‐ and sex‐matched healthy controls were enrolled in this study. Complex regional pain syndrome was diagnosed according to the modified International Association for the Study of Pain (IASP) criteria. We evaluated demographic, clinical and laboratory characteristics of the patients. Antioxidant enzymatic activities consisting of serum superoxide dismutase (SOD), glutathion peroxidase (GPX) and glutathione S‐transferase (GST) activities were measured using appropriate methods and compared with healthy controls.
Results
The mean age of the patients was 39.5 years and the mean duration of symptoms was 5.5 months. Complex regional pain syndrome devoleped after a traumatic event in 90% of patients. In 10% of patients there were no traumatic events. SOD, GPX and GST levels were significantly higher in patients with CRPS than healthy controls (P = 0.012, P = 0.036 and P = 0.016, respectively).
Conclusion
Our findings suggest a possible role of oxidative stress in the pathogenesis of CRPS. |
| doi_str_mv | 10.1111/1756-185X.12140 |
| format | Article |
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Complex regional pain syndrome (CRPS) type I is one of the most important problems with regard to physical medicine and rehabilitation. CRPS may cause not only higher therapeutic costs but also greater work time loss. The mechanism and pathogenesis of CRPS still remains unknown. Some findings indicating oxidative stress have been reported. This study was carried out to determine the role of oxidative stress in patients with CRPS.
Materials and methods
Twenty patients (13 women and seven men) with CRPS and 20 age‐ and sex‐matched healthy controls were enrolled in this study. Complex regional pain syndrome was diagnosed according to the modified International Association for the Study of Pain (IASP) criteria. We evaluated demographic, clinical and laboratory characteristics of the patients. Antioxidant enzymatic activities consisting of serum superoxide dismutase (SOD), glutathion peroxidase (GPX) and glutathione S‐transferase (GST) activities were measured using appropriate methods and compared with healthy controls.
Results
The mean age of the patients was 39.5 years and the mean duration of symptoms was 5.5 months. Complex regional pain syndrome devoleped after a traumatic event in 90% of patients. In 10% of patients there were no traumatic events. SOD, GPX and GST levels were significantly higher in patients with CRPS than healthy controls (P = 0.012, P = 0.036 and P = 0.016, respectively).
Conclusion
Our findings suggest a possible role of oxidative stress in the pathogenesis of CRPS.</description><identifier>ISSN: 1756-1841</identifier><identifier>EISSN: 1756-185X</identifier><identifier>DOI: 10.1111/1756-185X.12140</identifier><identifier>PMID: 24576270</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Adult ; Antioxidants - analysis ; Biomarkers - blood ; Case-Control Studies ; Female ; Glutathione Peroxidase - blood ; Glutathione Transferase - blood ; Humans ; Male ; Middle Aged ; Oxidative Stress ; Pain Measurement ; Reflex Sympathetic Dystrophy - blood ; Reflex Sympathetic Dystrophy - diagnosis ; regional pain syndromes ; soft tissue rheumatism ; Superoxide Dismutase - blood ; Time Factors</subject><ispartof>International journal of rheumatic diseases, 2014-02, Vol.17 (2), p.156-158</ispartof><rights>2013 Asia Pacific League of Associations for Rheumatology and Wiley Publishing Asia Pty Ltd</rights><rights>2013 Asia Pacific League of Associations for Rheumatology and Wiley Publishing Asia Pty Ltd.</rights><rights>International Journal of Rheumatic Diseases © 2014 Asia Pacific League of Associations for Rheumatology and Wiley Publishing Asia Pty Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4350-c03174225efafdf7ddee3e6e74ce46f31866773be20a3dd4dbe22d6443eb13403</citedby><cites>FETCH-LOGICAL-c4350-c03174225efafdf7ddee3e6e74ce46f31866773be20a3dd4dbe22d6443eb13403</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2F1756-185X.12140$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2F1756-185X.12140$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24576270$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Baykal, Tuba</creatorcontrib><creatorcontrib>Seferoglu, Buminhan</creatorcontrib><creatorcontrib>Karsan, Orhan</creatorcontrib><creatorcontrib>Kiziltunc, Ahmet</creatorcontrib><creatorcontrib>Senel, Kazim</creatorcontrib><title>Antioxidant profile in patients with complex regional pain syndrome type I</title><title>International journal of rheumatic diseases</title><addtitle>Int J Rheum Dis</addtitle><description>Objective
Complex regional pain syndrome (CRPS) type I is one of the most important problems with regard to physical medicine and rehabilitation. CRPS may cause not only higher therapeutic costs but also greater work time loss. The mechanism and pathogenesis of CRPS still remains unknown. Some findings indicating oxidative stress have been reported. This study was carried out to determine the role of oxidative stress in patients with CRPS.
Materials and methods
Twenty patients (13 women and seven men) with CRPS and 20 age‐ and sex‐matched healthy controls were enrolled in this study. Complex regional pain syndrome was diagnosed according to the modified International Association for the Study of Pain (IASP) criteria. We evaluated demographic, clinical and laboratory characteristics of the patients. Antioxidant enzymatic activities consisting of serum superoxide dismutase (SOD), glutathion peroxidase (GPX) and glutathione S‐transferase (GST) activities were measured using appropriate methods and compared with healthy controls.
Results
The mean age of the patients was 39.5 years and the mean duration of symptoms was 5.5 months. Complex regional pain syndrome devoleped after a traumatic event in 90% of patients. In 10% of patients there were no traumatic events. SOD, GPX and GST levels were significantly higher in patients with CRPS than healthy controls (P = 0.012, P = 0.036 and P = 0.016, respectively).
Conclusion
Our findings suggest a possible role of oxidative stress in the pathogenesis of CRPS.</description><subject>Adult</subject><subject>Antioxidants - analysis</subject><subject>Biomarkers - blood</subject><subject>Case-Control Studies</subject><subject>Female</subject><subject>Glutathione Peroxidase - blood</subject><subject>Glutathione Transferase - blood</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Oxidative Stress</subject><subject>Pain Measurement</subject><subject>Reflex Sympathetic Dystrophy - blood</subject><subject>Reflex Sympathetic Dystrophy - diagnosis</subject><subject>regional pain syndromes</subject><subject>soft tissue rheumatism</subject><subject>Superoxide Dismutase - blood</subject><subject>Time Factors</subject><issn>1756-1841</issn><issn>1756-185X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkDtPwzAURi0E4j2zoUgsLGnt-FXGqoLyqAAJEIjFcuMbMOSFnYr23-M2JQMLXnxln--TfRA6IrhHwuoTyUVMBvylRxLC8Aba7U42u5mRHbTn_QfGglAht9FOwrgUicS76HpYNraaW6PLJqpdldkcIltGtW4slI2Pvm3zHqVVUecwjxy82arUebgOjF-UxlUFRM2ihujqAG1lOvdwuN730dPF-ePoMp7cja9Gw0mcMspxnGJKJEsSDpnOTCaNAaAgQLIUmMgoGQghJZ1CgjU1hpkwJUYwRmFKKMN0H522veG5XzPwjSqsTyHPdQnVzCvCMeXsLPQE9OQP-lHNXPjAikoG8gxLHqh-S6Wu8t5BpmpnC-0WimC11KyWItVSqlppDonjde9sWoDp-F-vAeAt8B18Lv7rU8P7yW9x3Oasb2De5bT7VEJSydXz7VgNXh8Yv7kfqTH9AQ_vld8</recordid><startdate>201402</startdate><enddate>201402</enddate><creator>Baykal, Tuba</creator><creator>Seferoglu, Buminhan</creator><creator>Karsan, Orhan</creator><creator>Kiziltunc, Ahmet</creator><creator>Senel, Kazim</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>201402</creationdate><title>Antioxidant profile in patients with complex regional pain syndrome type I</title><author>Baykal, Tuba ; Seferoglu, Buminhan ; Karsan, Orhan ; Kiziltunc, Ahmet ; Senel, Kazim</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4350-c03174225efafdf7ddee3e6e74ce46f31866773be20a3dd4dbe22d6443eb13403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Antioxidants - analysis</topic><topic>Biomarkers - blood</topic><topic>Case-Control Studies</topic><topic>Female</topic><topic>Glutathione Peroxidase - blood</topic><topic>Glutathione Transferase - blood</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Oxidative Stress</topic><topic>Pain Measurement</topic><topic>Reflex Sympathetic Dystrophy - blood</topic><topic>Reflex Sympathetic Dystrophy - diagnosis</topic><topic>regional pain syndromes</topic><topic>soft tissue rheumatism</topic><topic>Superoxide Dismutase - blood</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Baykal, Tuba</creatorcontrib><creatorcontrib>Seferoglu, Buminhan</creatorcontrib><creatorcontrib>Karsan, Orhan</creatorcontrib><creatorcontrib>Kiziltunc, Ahmet</creatorcontrib><creatorcontrib>Senel, Kazim</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of rheumatic diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Baykal, Tuba</au><au>Seferoglu, Buminhan</au><au>Karsan, Orhan</au><au>Kiziltunc, Ahmet</au><au>Senel, Kazim</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antioxidant profile in patients with complex regional pain syndrome type I</atitle><jtitle>International journal of rheumatic diseases</jtitle><addtitle>Int J Rheum Dis</addtitle><date>2014-02</date><risdate>2014</risdate><volume>17</volume><issue>2</issue><spage>156</spage><epage>158</epage><pages>156-158</pages><issn>1756-1841</issn><eissn>1756-185X</eissn><abstract>Objective
Complex regional pain syndrome (CRPS) type I is one of the most important problems with regard to physical medicine and rehabilitation. CRPS may cause not only higher therapeutic costs but also greater work time loss. The mechanism and pathogenesis of CRPS still remains unknown. Some findings indicating oxidative stress have been reported. This study was carried out to determine the role of oxidative stress in patients with CRPS.
Materials and methods
Twenty patients (13 women and seven men) with CRPS and 20 age‐ and sex‐matched healthy controls were enrolled in this study. Complex regional pain syndrome was diagnosed according to the modified International Association for the Study of Pain (IASP) criteria. We evaluated demographic, clinical and laboratory characteristics of the patients. Antioxidant enzymatic activities consisting of serum superoxide dismutase (SOD), glutathion peroxidase (GPX) and glutathione S‐transferase (GST) activities were measured using appropriate methods and compared with healthy controls.
Results
The mean age of the patients was 39.5 years and the mean duration of symptoms was 5.5 months. Complex regional pain syndrome devoleped after a traumatic event in 90% of patients. In 10% of patients there were no traumatic events. SOD, GPX and GST levels were significantly higher in patients with CRPS than healthy controls (P = 0.012, P = 0.036 and P = 0.016, respectively).
Conclusion
Our findings suggest a possible role of oxidative stress in the pathogenesis of CRPS.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>24576270</pmid><doi>10.1111/1756-185X.12140</doi><tpages>3</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Antioxidants - analysis Biomarkers - blood Case-Control Studies Female Glutathione Peroxidase - blood Glutathione Transferase - blood Humans Male Middle Aged Oxidative Stress Pain Measurement Reflex Sympathetic Dystrophy - blood Reflex Sympathetic Dystrophy - diagnosis regional pain syndromes soft tissue rheumatism Superoxide Dismutase - blood Time Factors |
| title | Antioxidant profile in patients with complex regional pain syndrome type I |
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