Free light chain content in culture media reflects recombinant monoclonal antibody productivity and quality

Monoclonal antibodies (mAbs) are currently the dominant class of biopharmaceuticals. Due to the high dosage requirements of most mAb therapeutics, high productivity and low aggregation are prevailing criteria during cell line generation and process development. Given that light chains (LCs) play an...

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Veröffentlicht in:	Biotechnology progress 2013-09, Vol.29 (5), p.1131-1139
Hauptverfasser:	Bhoskar, Prachi, Belongia, Brett, Smith, Robert, Yoon, Seongkyu, Carter, Tyler, Xu, Jin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - biosynthesis antibody aggregation antibody productivity cell culture optimization Cell Survival CHO Cells Chromatography, Liquid clone selection Cloning, Molecular Cricetulus Culture Media - chemistry Electrophoresis, Polyacrylamide Gel free light chains Gene Expression Regulation Immunoglobulin G - biosynthesis Immunoglobulin Light Chains - biosynthesis Mass Spectrometry Protein Folding Recombinant Proteins - biosynthesis
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