A multiplex technology platform for the rapid analysis of clinically actionable genetic alterations and validation for BRAF p.V600E detection in 1549 cytologic and histologic specimens

Current clinicopathologic assessment of malignant neoplastic diseases entails the analysis of specific genetic alterations that provide diagnostic, prognostic, or therapy-determining information. To develop and validate a robust molecular method to detect clinically relevant mutations in various tis...

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Veröffentlicht in:	Archives of pathology & laboratory medicine (1976) 2014-03, Vol.138 (3), p.371-378
Hauptverfasser:	Smith, David L, Lamy, Aude, Beaudenon-Huibregtse, Sylvie, Sesboüé, Richard, Laosinchai-Wolf, Walairat, Sabourin, Jean-Christophe, Labourier, Emmanuel
Format:	Artikel
Sprache:	eng
Schlagworte:	Colorectal cancer Colorectal Neoplasms - diagnosis Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology DNA Mutational Analysis - instrumentation DNA Mutational Analysis - methods Flow cytometry Formaldehyde Gene mutations Genes Humans Kinases Laboratories Metastasis Methods Mutation Oncology Pathology Plasmids Polymerase chain reaction Proto-Oncogene Proteins B-raf - genetics Reproducibility of Results Sensitivity and Specificity Technology Thyroid cancer Thyroid diseases Thyroid Neoplasms - diagnosis Thyroid Neoplasms - genetics Thyroid Neoplasms - pathology Thyroid Nodule - diagnosis Thyroid Nodule - genetics Thyroid Nodule - pathology
Online-Zugang:	Volltext
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