Organelle-selective fluorescent Cu2+ ion probes: revealing the endoplasmic reticulum as a reservoir for Cu-overloading
Two novel Cu(2+) sensors, 1 and 2, bearing naphthalimide and a DPA moiety were synthesized to study copper accumulation in organelles by selective Cu(2+) sensing. The ER-selective Cu(2+) sensor 1 that we developed serves as a valuable tool for understanding the subcellular compartmentalization and r...
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| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2014-03, Vol.50 (24), p.3197-3200 |
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| container_end_page | 3200 |
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| container_issue | 24 |
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| container_title | Chemical communications (Cambridge, England) |
| container_volume | 50 |
| creator | Lee, Yun Hak Park, Nayoung Park, Young Bin Hwang, Yu Jeong Kang, Chulhun Kim, Jong Seung |
| description | Two novel Cu(2+) sensors, 1 and 2, bearing naphthalimide and a DPA moiety were synthesized to study copper accumulation in organelles by selective Cu(2+) sensing. The ER-selective Cu(2+) sensor 1 that we developed serves as a valuable tool for understanding the subcellular compartmentalization and roles of copper ions in physiology and pathophysiology. |
| doi_str_mv | 10.1039/c4cc00091a |
| format | Article |
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| identifier | EISSN: 1364-548X |
| ispartof | Chemical communications (Cambridge, England), 2014-03, Vol.50 (24), p.3197-3200 |
| issn | 1364-548X |
| language | eng |
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| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Copper - analysis Copper - metabolism Endoplasmic Reticulum - chemistry Endoplasmic Reticulum - metabolism Fluorescent Dyes - chemical synthesis Fluorescent Dyes - chemistry Fluorescent Dyes - metabolism Hep G2 Cells Humans Ions - analysis Ions - metabolism Molecular Structure Organelles - chemistry Organelles - metabolism Organometallic Compounds - chemical synthesis Organometallic Compounds - chemistry Organometallic Compounds - metabolism |
| title | Organelle-selective fluorescent Cu2+ ion probes: revealing the endoplasmic reticulum as a reservoir for Cu-overloading |
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