Organelle-selective fluorescent Cu2+ ion probes: revealing the endoplasmic reticulum as a reservoir for Cu-overloading

Two novel Cu(2+) sensors, 1 and 2, bearing naphthalimide and a DPA moiety were synthesized to study copper accumulation in organelles by selective Cu(2+) sensing. The ER-selective Cu(2+) sensor 1 that we developed serves as a valuable tool for understanding the subcellular compartmentalization and r...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2014-03, Vol.50 (24), p.3197-3200
Hauptverfasser:	Lee, Yun Hak, Park, Nayoung, Park, Young Bin, Hwang, Yu Jeong, Kang, Chulhun, Kim, Jong Seung
Format:	Artikel
Sprache:	eng
Schlagworte:	Copper - analysis Copper - metabolism Endoplasmic Reticulum - chemistry Endoplasmic Reticulum - metabolism Fluorescent Dyes - chemical synthesis Fluorescent Dyes - chemistry Fluorescent Dyes - metabolism Hep G2 Cells Humans Ions - analysis Ions - metabolism Molecular Structure Organelles - chemistry Organelles - metabolism Organometallic Compounds - chemical synthesis Organometallic Compounds - chemistry Organometallic Compounds - metabolism
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Beschreibung
Zusammenfassung:	Two novel Cu(2+) sensors, 1 and 2, bearing naphthalimide and a DPA moiety were synthesized to study copper accumulation in organelles by selective Cu(2+) sensing. The ER-selective Cu(2+) sensor 1 that we developed serves as a valuable tool for understanding the subcellular compartmentalization and roles of copper ions in physiology and pathophysiology.
ISSN:	1364-548X
DOI:	10.1039/c4cc00091a