Incidence of bcr-abl fusion transcripts in healthy individuals

Bcr-abl fusion transcripts, resulting from translocation t(9;22), are hallmarks of Philadelphia chromosome positive (Ph+) leukemias. This translocation is detected in >90% of patients with chronic myelogenous leukemia and ~20% of acute lymphoblastic leukemia patients, which predominantly express...

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Veröffentlicht in:	Molecular medicine reports 2014-04, Vol.9 (4), p.1271-1276
Hauptverfasser:	ISMAIL, SAID I, NAFFA, RANDA G, YOUSEF, AL-MOTASSEM F, GHANIM, MAJD T
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute lymphoblastic leukemia Adolescent Adult Adults Age Age Distribution Aged Aged, 80 and over BCR-ABL BCR-ABL protein Binding sites Bone marrow Child Child, Preschool Children Children & youth Chromosomes chronic myelogenous leukemia Chronic myeloid leukemia Differential diagnosis Female Females Fusion protein Fusion Proteins, bcr-abl - genetics Fusion Proteins, bcr-abl - metabolism Gender Genetic aspects Genetic transcription GTP-binding protein Health Health aspects Humans Kinases Leukemia Lymphatic leukemia Male Males Middle Aged Myeloid leukemia Philadelphia chromosome Polymerase Chain Reaction Proteins Reverse transcription Ribonucleic acid RNA RNA, Messenger - genetics RNA, Messenger - metabolism Studies Translocation (Genetics) translocation t(9/22) Young Adult
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