Regulation of MKL1 via actin cytoskeleton dynamics drives adipocyte differentiation

Cellular differentiation is regulated through activation and repression of defined transcription factors. A hallmark of differentiation is a pronounced change in cell shape, which is determined by dynamics of the actin cytoskeleton. Here we show that regulation of the transcriptional coactivator MKL...

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Veröffentlicht in:	Nature communications 2014-02, Vol.5 (1), p.3368-3368, Article 3368
Hauptverfasser:	Nobusue, Hiroyuki, Onishi, Nobuyuki, Shimizu, Takatsune, Sugihara, Eiji, Oki, Yoshinao, Sumikawa, Yuko, Chiyoda, Tatsuyuki, Akashi, Koichi, Saya, Hideyuki, Kano, Koichiro
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/106 13/109 13/51 13/89 14/19 38/61 3T3-L1 Cells 631/136/142 631/80/128/1276 631/80/86 692/698/690/2816 Actin Cytoskeleton - metabolism Actins - genetics Actins - metabolism Adipocytes - cytology Adipocytes - metabolism Animals Cell Differentiation Cell Line Gene Expression Profiling Gene Expression Regulation Humanities and Social Sciences Immunoblotting Kinetics Mice Microscopy, Fluorescence multidisciplinary NIH 3T3 Cells Oligonucleotide Array Sequence Analysis PPAR gamma - genetics PPAR gamma - metabolism Protein Binding Protein Transport Reverse Transcriptase Polymerase Chain Reaction rho-Associated Kinases - genetics rho-Associated Kinases - metabolism rhoA GTP-Binding Protein RNA Interference Science Science (multidisciplinary) Signal Transduction Time-Lapse Imaging Trans-Activators - genetics Trans-Activators - metabolism
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