Essential Role of Program Death 1-Ligand 1 in Regulatory T-Cell―Afforded Protection Against Blood―Brain Barrier Damage After Stroke

Our recent research revealed that adoptively transferred regulatory T cells (Tregs) reduced acute ischemic brain injury by inhibiting neutrophil-derived matrix metalloproteinase-9 (MMP-9) and protecting against blood-brain barrier damage. The mechanisms underlying Treg interactions with neutrophils...

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Veröffentlicht in:	Stroke (1970) 2014-03, Vol.45 (3), p.857-864
Hauptverfasser:	PEIYING LI, LEILEI MAO, XIANGRONG LIU, YU GAN, JING ZHENG, THOMSON, Angus W, YANQIN GAO, JUN CHEN, XIAOMING HU
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B7-H1 Antigen - physiology Biological and medical sciences Blood-Brain Barrier - pathology Brain - pathology Brain Ischemia - pathology Cell Count Coculture Techniques Cytokines - metabolism Enzyme-Linked Immunosorbent Assay Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Immunohistochemistry Infarction, Middle Cerebral Artery - pathology Ischemic Attack, Transient - pathology Male Matrix Metalloproteinase 9 - metabolism Medical sciences Mice Mice, Inbred C57BL Nervous system (semeiology, syndromes) Nervous System Diseases - physiopathology Neurology Neutrophil Infiltration - physiology Neutrophils - physiology Stroke - pathology T-Lymphocytes, Regulatory - physiology Vascular diseases and vascular malformations of the nervous system
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