Genetic selection for benzodiazepine ataxia produces functional changes in the γ-aminobutyric acid receptor chloride channel complex

The γ-aminobutyric acid (GABA) receptor-operated chloride channel complex was evaluated in mice selected for differential sensitivity to the ataxic effects of diazepam (diazepam-sensitive (DS) and diazepam-resistant (DR) lines). The ataxic effects of several drugs purported to produce some of their...

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Veröffentlicht in:	Brain research 1988-06, Vol.452 (1), p.118-126
Hauptverfasser:	Allan, Andrea M., Gallaher, Edward J., Gionet, Susanne E., Harris, R. Adron
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Ataxia - chemically induced Ataxia - genetics Ataxia - metabolism Benzodiazepine benzodiazepines Biological and medical sciences brain Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors chloride Chlorides - pharmacokinetics Chlorides - physiology Diazepam - pharmacology Diazepam-resistant (DR) mouse Diazepam-sensitive (DS) mouse Ethanol - pharmacology Flunitrazepam - pharmacology Fundamental and applied biological sciences. Psychology gamma -aminobutyric acid Ion Channels - physiology Isoxazoles - pharmacology Mice Muscimol - pharmacology Phenobarbital - pharmacology Receptors, GABA-A - genetics Receptors, GABA-A - physiology Selective breeding t-Butylbicyclophosphorothionate (TBPS) Time Factors Vertebrates: nervous system and sense organs γ-Aminobutyric acid (GABA)
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