Design and Synthesis of Truncated EGF-A Peptides that Restore LDL-R Recycling in the Presence of PCSK9 In Vitro

Disrupting the binding interaction between proprotein convertase (PCSK9) and the epidermal growth factor-like domain A (EGF-A domain) in the low-density lipoprotein receptor (LDL-R) is a promising strategy to promote LDL-R recycling and thereby lower circulating cholesterol levels. In this study, tr...

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Veröffentlicht in:	Chemistry & biology 2014-02, Vol.21 (2), p.284-294
Hauptverfasser:	Schroeder, Christina I., Swedberg, Joakim E., Withka, Jane M., Rosengren, K. Johan, Akcan, Muharrem, Clayton, Daniel J., Daly, Norelle L., Cheneval, Olivier, Borzilleri, Kris A., Griffor, Matt, Stock, Ingrid, Colless, Barbara, Walsh, Phillip, Sunderland, Philip, Reyes, Allan, Dullea, Robert, Ammirati, Mark, Liu, Shenping, McClure, Kim F., Tu, Meihua, Bhattacharya, Samit K., Liras, Spiros, Price, David A., Craik, David J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Binding Sites Cell Line Cholesterol - metabolism Epidermal Growth Factor - chemistry Fluorescence Resonance Energy Transfer Humans Molecular Dynamics Simulation Molecular Sequence Data Mutagenesis Peptides - chemical synthesis Peptides - chemistry Peptides - metabolism Proprotein Convertase 9 Proprotein Convertases - chemistry Proprotein Convertases - genetics Proprotein Convertases - metabolism Protein Binding Protein Structure, Secondary Protein Structure, Tertiary Receptors, LDL - metabolism Serine Endopeptidases - chemistry Serine Endopeptidases - genetics Serine Endopeptidases - metabolism
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