Vitamin D receptor rs2228570 polymorphism and susceptibly to ovarian cancer: a meta-analysis
The role of vitamin D receptor (VDR) rs2228570 polymorphism on the risk of ovarian cancer has been studied in many studies, but the relationship between VDR rs2228570 polymorphism and ovarian cancer is still unclear. We thus performed a meta-analysis of published studies to provide a comprehensive a...
Gespeichert in:
Veröffentlicht in: | Tumor biology 2014-02, Vol.35 (2), p.1319-1322 |
---|---|
Hauptverfasser: | , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 1322 |
---|---|
container_issue | 2 |
container_start_page | 1319 |
container_title | Tumor biology |
container_volume | 35 |
creator | Li, Su Xu, Hui Li, Shuang-Cheng Qi, Xiang-Qun Sun, Wen-Juan |
description | The role of vitamin D receptor (VDR) rs2228570 polymorphism on the risk of ovarian cancer has been studied in many studies, but the relationship between VDR rs2228570 polymorphism and ovarian cancer is still unclear. We thus performed a meta-analysis of published studies to provide a comprehensive assessment of the association. Fourteen individual studies with a total of 10,964 subjects were finally included into the meta-analysis. We assessed the association by calculating the pooled odds ratio (OR) with 95 % confidence intervals (95 % CI). There was no heterogeneity among those included studies. Meta-analysis of 14 studies showed that the VDR rs2228570 polymorphism was associated with risk of ovarian cancer under three main comparison models (T versus C: OR = 1.09, 95 % CI 1.03 to 1.15,
P
= 0.004; TT versus CC: OR = 1.17, 95 % CI 1.04 to 1.32,
P
= 0.01; and TT/CT versus CC: OR = 1.12, 95 % CI 1.03 to 1.21,
P
= 0.007). Subgroup analysis in Caucasians further identified the obvious association. There was no evidence of publications bias. These data from the meta-analysis suggest that VDR rs2228570 polymorphism is associated with risk of ovarian cancer in Caucasians. More studies are warranted to assess the association between the VDR rs2228570 polymorphism and ovarian cancer in Asians and Africans. |
doi_str_mv | 10.1007/s13277-013-1175-3 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1501837732</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1501837732</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-20853d801a7bb671347d0a5032fc16a51f4ef30aa08e8d9c9424b47c53eee9583</originalsourceid><addsrcrecordid>eNp1kE9rFjEQh0NR7B_9AL2UgBcv0ZlM8ibbm1StQsGL9iSE7G5Wt-xu1mRXeL9987KtFMHTDMwzvxkexs4R3iKAeZeRpDECkASi0YKO2AkqSQLIwrPSA4JQ0tIxO835DgB1Ve1esGOpkHZGyRP247Zf_NhP_ANPoQnzEhNPWUpptQE-x2E_xjT_6vPI_dTyvOYD1NfDni-Rxz8-9X7ijZ-akC6552NYvPCTH_a5zy_Z884PObx6qGfs-6eP364-i5uv11-u3t-IhoxchASrqbWA3tT1ziAp04LXQLJrcOc1dip0BN6DDbatmkpJVSvTaAohVNrSGXuz5c4p_l5DXtzYlz-HwU8hrtmhBrRkDMmCvv4HvYtrKv9uFKCqoCoUblSTYs4pdG5O_ejT3iG4g3q3qXdFvTuod1R2Lh6S13oM7d-NR9cFkBuQy2j6GdKT0_9NvQcmkoxq</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1501014909</pqid></control><display><type>article</type><title>Vitamin D receptor rs2228570 polymorphism and susceptibly to ovarian cancer: a meta-analysis</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Li, Su ; Xu, Hui ; Li, Shuang-Cheng ; Qi, Xiang-Qun ; Sun, Wen-Juan</creator><creatorcontrib>Li, Su ; Xu, Hui ; Li, Shuang-Cheng ; Qi, Xiang-Qun ; Sun, Wen-Juan</creatorcontrib><description>The role of vitamin D receptor (VDR) rs2228570 polymorphism on the risk of ovarian cancer has been studied in many studies, but the relationship between VDR rs2228570 polymorphism and ovarian cancer is still unclear. We thus performed a meta-analysis of published studies to provide a comprehensive assessment of the association. Fourteen individual studies with a total of 10,964 subjects were finally included into the meta-analysis. We assessed the association by calculating the pooled odds ratio (OR) with 95 % confidence intervals (95 % CI). There was no heterogeneity among those included studies. Meta-analysis of 14 studies showed that the VDR rs2228570 polymorphism was associated with risk of ovarian cancer under three main comparison models (T versus C: OR = 1.09, 95 % CI 1.03 to 1.15,
P
= 0.004; TT versus CC: OR = 1.17, 95 % CI 1.04 to 1.32,
P
= 0.01; and TT/CT versus CC: OR = 1.12, 95 % CI 1.03 to 1.21,
P
= 0.007). Subgroup analysis in Caucasians further identified the obvious association. There was no evidence of publications bias. These data from the meta-analysis suggest that VDR rs2228570 polymorphism is associated with risk of ovarian cancer in Caucasians. More studies are warranted to assess the association between the VDR rs2228570 polymorphism and ovarian cancer in Asians and Africans.</description><identifier>ISSN: 1010-4283</identifier><identifier>EISSN: 1423-0380</identifier><identifier>DOI: 10.1007/s13277-013-1175-3</identifier><identifier>PMID: 24136742</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Asian Continental Ancestry Group - genetics ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; European Continental Ancestry Group - genetics ; Female ; Genetic Association Studies ; Genetic Predisposition to Disease ; Genetics ; Humans ; Meta-analysis ; Ovarian cancer ; Ovarian Neoplasms - genetics ; Ovarian Neoplasms - pathology ; Polymorphism ; Receptors, Calcitriol - genetics ; Research Article ; Risk Factors ; Vitamin D ; White people</subject><ispartof>Tumor biology, 2014-02, Vol.35 (2), p.1319-1322</ispartof><rights>International Society of Oncology and BioMarkers (ISOBM) 2013</rights><rights>International Society of Oncology and BioMarkers (ISOBM) 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-20853d801a7bb671347d0a5032fc16a51f4ef30aa08e8d9c9424b47c53eee9583</citedby><cites>FETCH-LOGICAL-c372t-20853d801a7bb671347d0a5032fc16a51f4ef30aa08e8d9c9424b47c53eee9583</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s13277-013-1175-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s13277-013-1175-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24136742$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Su</creatorcontrib><creatorcontrib>Xu, Hui</creatorcontrib><creatorcontrib>Li, Shuang-Cheng</creatorcontrib><creatorcontrib>Qi, Xiang-Qun</creatorcontrib><creatorcontrib>Sun, Wen-Juan</creatorcontrib><title>Vitamin D receptor rs2228570 polymorphism and susceptibly to ovarian cancer: a meta-analysis</title><title>Tumor biology</title><addtitle>Tumor Biol</addtitle><addtitle>Tumour Biol</addtitle><description>The role of vitamin D receptor (VDR) rs2228570 polymorphism on the risk of ovarian cancer has been studied in many studies, but the relationship between VDR rs2228570 polymorphism and ovarian cancer is still unclear. We thus performed a meta-analysis of published studies to provide a comprehensive assessment of the association. Fourteen individual studies with a total of 10,964 subjects were finally included into the meta-analysis. We assessed the association by calculating the pooled odds ratio (OR) with 95 % confidence intervals (95 % CI). There was no heterogeneity among those included studies. Meta-analysis of 14 studies showed that the VDR rs2228570 polymorphism was associated with risk of ovarian cancer under three main comparison models (T versus C: OR = 1.09, 95 % CI 1.03 to 1.15,
P
= 0.004; TT versus CC: OR = 1.17, 95 % CI 1.04 to 1.32,
P
= 0.01; and TT/CT versus CC: OR = 1.12, 95 % CI 1.03 to 1.21,
P
= 0.007). Subgroup analysis in Caucasians further identified the obvious association. There was no evidence of publications bias. These data from the meta-analysis suggest that VDR rs2228570 polymorphism is associated with risk of ovarian cancer in Caucasians. More studies are warranted to assess the association between the VDR rs2228570 polymorphism and ovarian cancer in Asians and Africans.</description><subject>Asian Continental Ancestry Group - genetics</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>European Continental Ancestry Group - genetics</subject><subject>Female</subject><subject>Genetic Association Studies</subject><subject>Genetic Predisposition to Disease</subject><subject>Genetics</subject><subject>Humans</subject><subject>Meta-analysis</subject><subject>Ovarian cancer</subject><subject>Ovarian Neoplasms - genetics</subject><subject>Ovarian Neoplasms - pathology</subject><subject>Polymorphism</subject><subject>Receptors, Calcitriol - genetics</subject><subject>Research Article</subject><subject>Risk Factors</subject><subject>Vitamin D</subject><subject>White people</subject><issn>1010-4283</issn><issn>1423-0380</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kE9rFjEQh0NR7B_9AL2UgBcv0ZlM8ibbm1StQsGL9iSE7G5Wt-xu1mRXeL9987KtFMHTDMwzvxkexs4R3iKAeZeRpDECkASi0YKO2AkqSQLIwrPSA4JQ0tIxO835DgB1Ve1esGOpkHZGyRP247Zf_NhP_ANPoQnzEhNPWUpptQE-x2E_xjT_6vPI_dTyvOYD1NfDni-Rxz8-9X7ijZ-akC6552NYvPCTH_a5zy_Z884PObx6qGfs-6eP364-i5uv11-u3t-IhoxchASrqbWA3tT1ziAp04LXQLJrcOc1dip0BN6DDbatmkpJVSvTaAohVNrSGXuz5c4p_l5DXtzYlz-HwU8hrtmhBrRkDMmCvv4HvYtrKv9uFKCqoCoUblSTYs4pdG5O_ejT3iG4g3q3qXdFvTuod1R2Lh6S13oM7d-NR9cFkBuQy2j6GdKT0_9NvQcmkoxq</recordid><startdate>20140201</startdate><enddate>20140201</enddate><creator>Li, Su</creator><creator>Xu, Hui</creator><creator>Li, Shuang-Cheng</creator><creator>Qi, Xiang-Qun</creator><creator>Sun, Wen-Juan</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20140201</creationdate><title>Vitamin D receptor rs2228570 polymorphism and susceptibly to ovarian cancer: a meta-analysis</title><author>Li, Su ; Xu, Hui ; Li, Shuang-Cheng ; Qi, Xiang-Qun ; Sun, Wen-Juan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-20853d801a7bb671347d0a5032fc16a51f4ef30aa08e8d9c9424b47c53eee9583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Asian Continental Ancestry Group - genetics</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>European Continental Ancestry Group - genetics</topic><topic>Female</topic><topic>Genetic Association Studies</topic><topic>Genetic Predisposition to Disease</topic><topic>Genetics</topic><topic>Humans</topic><topic>Meta-analysis</topic><topic>Ovarian cancer</topic><topic>Ovarian Neoplasms - genetics</topic><topic>Ovarian Neoplasms - pathology</topic><topic>Polymorphism</topic><topic>Receptors, Calcitriol - genetics</topic><topic>Research Article</topic><topic>Risk Factors</topic><topic>Vitamin D</topic><topic>White people</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Su</creatorcontrib><creatorcontrib>Xu, Hui</creatorcontrib><creatorcontrib>Li, Shuang-Cheng</creatorcontrib><creatorcontrib>Qi, Xiang-Qun</creatorcontrib><creatorcontrib>Sun, Wen-Juan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Tumor biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Su</au><au>Xu, Hui</au><au>Li, Shuang-Cheng</au><au>Qi, Xiang-Qun</au><au>Sun, Wen-Juan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitamin D receptor rs2228570 polymorphism and susceptibly to ovarian cancer: a meta-analysis</atitle><jtitle>Tumor biology</jtitle><stitle>Tumor Biol</stitle><addtitle>Tumour Biol</addtitle><date>2014-02-01</date><risdate>2014</risdate><volume>35</volume><issue>2</issue><spage>1319</spage><epage>1322</epage><pages>1319-1322</pages><issn>1010-4283</issn><eissn>1423-0380</eissn><abstract>The role of vitamin D receptor (VDR) rs2228570 polymorphism on the risk of ovarian cancer has been studied in many studies, but the relationship between VDR rs2228570 polymorphism and ovarian cancer is still unclear. We thus performed a meta-analysis of published studies to provide a comprehensive assessment of the association. Fourteen individual studies with a total of 10,964 subjects were finally included into the meta-analysis. We assessed the association by calculating the pooled odds ratio (OR) with 95 % confidence intervals (95 % CI). There was no heterogeneity among those included studies. Meta-analysis of 14 studies showed that the VDR rs2228570 polymorphism was associated with risk of ovarian cancer under three main comparison models (T versus C: OR = 1.09, 95 % CI 1.03 to 1.15,
P
= 0.004; TT versus CC: OR = 1.17, 95 % CI 1.04 to 1.32,
P
= 0.01; and TT/CT versus CC: OR = 1.12, 95 % CI 1.03 to 1.21,
P
= 0.007). Subgroup analysis in Caucasians further identified the obvious association. There was no evidence of publications bias. These data from the meta-analysis suggest that VDR rs2228570 polymorphism is associated with risk of ovarian cancer in Caucasians. More studies are warranted to assess the association between the VDR rs2228570 polymorphism and ovarian cancer in Asians and Africans.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>24136742</pmid><doi>10.1007/s13277-013-1175-3</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1010-4283 |
ispartof | Tumor biology, 2014-02, Vol.35 (2), p.1319-1322 |
issn | 1010-4283 1423-0380 |
language | eng |
recordid | cdi_proquest_miscellaneous_1501837732 |
source | MEDLINE; SpringerLink Journals - AutoHoldings |
subjects | Asian Continental Ancestry Group - genetics Biomedical and Life Sciences Biomedicine Cancer Research European Continental Ancestry Group - genetics Female Genetic Association Studies Genetic Predisposition to Disease Genetics Humans Meta-analysis Ovarian cancer Ovarian Neoplasms - genetics Ovarian Neoplasms - pathology Polymorphism Receptors, Calcitriol - genetics Research Article Risk Factors Vitamin D White people |
title | Vitamin D receptor rs2228570 polymorphism and susceptibly to ovarian cancer: a meta-analysis |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T17%3A36%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Vitamin%20D%20receptor%20rs2228570%20polymorphism%20and%20susceptibly%20to%20ovarian%20cancer:%20a%20meta-analysis&rft.jtitle=Tumor%20biology&rft.au=Li,%20Su&rft.date=2014-02-01&rft.volume=35&rft.issue=2&rft.spage=1319&rft.epage=1322&rft.pages=1319-1322&rft.issn=1010-4283&rft.eissn=1423-0380&rft_id=info:doi/10.1007/s13277-013-1175-3&rft_dat=%3Cproquest_cross%3E1501837732%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1501014909&rft_id=info:pmid/24136742&rfr_iscdi=true |