Ribosomal protein S3 interacts with the NF-κB inhibitor IκBα

•RPS3 interacts with the NF-κB inhibitor IκBα in resting cells and in vitro.•The ankyrin-repeats of IκBα mediate the interaction with the RPS3 C-domain.•IκBα facilitates the formation of a cytoplasmic complex with RPS3 and p65. Ribosomal protein S3 (RPS3) is part of nuclear, transcriptionally active...

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Veröffentlicht in:	FEBS letters 2014-03, Vol.588 (5), p.659-664
Hauptverfasser:	Stanborough, Tamsyn, Niederhauser, Johannes, Koch, Barbara, Bergler, Helmut, Pertschy, Brigitte
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Ankyrin Repeat HEK293 Cells Humans I-kappa B Proteins - chemistry I-kappa B Proteins - metabolism IKK inhibitor of NF-κB IκB IκB kinase IκBα Molecular Sequence Data NF-KappaB Inhibitor alpha NF-κB NF-κB inhibitor NLS Nuclear factor kappa B nuclear localization sequence p65 Protein Binding Protein Interaction Mapping Protein Multimerization Protein Structure, Secondary Ribosomal protein S3 Ribosomal Proteins - chemistry Ribosomal Proteins - metabolism TEV tobacco etch virus Transcription Factor RelA - chemistry Transcription Factor RelA - metabolism
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