Development and evaluation of a tacrolimus cream formulation using a binary solvent system

We developed an oil/water-type tacrolimus (FK506) cream formulation as an alternative to Protopic ointment for atopic dermatitis treatment. We determined the effects of solvents used in topical preparations on FK506 solubility and stability, and evaluated FK506 transdermal absorption into rat skin f...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	International journal of pharmaceutics 2014-04, Vol.464 (1-2), p.19-26
Hauptverfasser:	Yamanaka, Masayuki, Yokota, Shoji, Iwao, Yasunori, Noguchi, Shuji, Itai, Shigeru
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binary solvent Chemistry, Pharmaceutical Cream Drug Discovery - methods Emulsion Male Rats Rats, Sprague-Dawley Skin Absorption - drug effects Skin Absorption - physiology Skin Cream - chemistry Skin Cream - pharmacokinetics Solvents - chemistry Surfactant Tacrolimus Tacrolimus - chemistry Tacrolimus - pharmacokinetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!