Marked effects of combined TPGS and PVA emulsifiers in the fabrication of etoposide-loaded PLGA-PEG nanoparticles: In vitro and in vivo evaluation

Using TPGS in combination with PVA as an emulsifier in fabrication of etoposide (ET) loaded nanoparticles (NPs) markedly increased encapsulation efficiency, sustained drug release and resulted in nanoparticles with noticeable sustainable in vivo disposition. The purpose of this study was to investig...

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Veröffentlicht in:	International journal of pharmaceutics 2014-04, Vol.464 (1-2), p.135-144
Hauptverfasser:	Saadati, Roonak, Dadashzadeh, Simin
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Tocopherol - administration & dosage alpha-Tocopherol - chemistry Animals Drug Evaluation, Preclinical - methods Dual emulsifiers Emulsifying Agents - administration & dosage Emulsifying Agents - chemistry Etoposide Etoposide - chemical synthesis Male Nanoparticles Nanoparticles - chemistry Pharmacokinetics PLGA-PEG Polyethylene Glycols - administration & dosage Polyethylene Glycols - chemical synthesis Polyethylene Glycols - chemistry Polyglactin 910 - chemical synthesis Polyvinyl Alcohol - administration & dosage Polyvinyl Alcohol - chemistry Rats Rats, Wistar TPGS
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