MicroRNA-150 inhibits expression of adiponectin receptor 2 and is a potential therapeutic target in patients with chronic heart failure

Background Adiponectin is an anti-inflammatory adipocytokine believed to be involved in the pathogenesis of chronic heart failure (CHF). We aimed to characterize the expression of adiponectin and its receptors in CHF and to assess the impact of microRNAs on the cardiac adiponectin system. Methods Ex...

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Veröffentlicht in:	The Journal of heart and lung transplantation 2014-03, Vol.33 (3), p.252-260
Hauptverfasser:	Kreth, Simone, MD, PhD, Ledderose, Carola, VMD, Schütz, Stefanie, PhD, Beiras, Andres, MD, Heyn, Jens, MD, Weis, Florian, MD, Beiras-Fernandez, Andres, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	adipocytokines Adiponectin - metabolism adiponectin receptors adiponectin resistance Adult Cells, Cultured Chronic Disease Gene Silencing - drug effects heart failure Heart Failure - drug therapy Heart Failure - metabolism Heart Failure - pathology Humans microRNA-150 MicroRNAs - pharmacology Middle Aged myocardial stress Myocardium - metabolism Myocardium - pathology Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Receptors, Adiponectin - drug effects Receptors, Adiponectin - genetics Receptors, Adiponectin - metabolism RNA, Messenger - metabolism RNA, Small Interfering - pharmacology Surgery Up-Regulation - drug effects
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