Endotoxicity of Lipopolysaccharide as a Determinant of T-Cell−Mediated Colitis Induction in Mice

Background & Aims The intestinal microbiota is an important determinant of the mucosal response. In patients with inflammatory bowel diseases, the mucosal immune system has inappropriate interactions with the intestinal microbiota. We investigated how the composition of the intestinal microbiota...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2014-03, Vol.146 (3), p.765-775
Hauptverfasser:	Gronbach, Kerstin, Flade, Isabell, Holst, Otto, Lindner, Buko, Ruscheweyh, Hans Joachim, Wittmann, Alexandra, Menz, Sarah, Schwiertz, Andreas, Adam, Patrick, Stecher, Bärbel, Josenhans, Christine, Suerbaum, Sebastian, Gruber, Achim D, Kulik, Andreas, Huson, Daniel, Autenrieth, Ingo B, Frick, Julia-Stefanie
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacteria Colitis - chemically induced Colitis - pathology Colitis - physiopathology Colon - microbiology Colon - pathology Disease Models, Animal Escherichia coli - isolation & purification Female Gastroenterology and Hepatology Hemostasis - physiology Homeodomain Proteins - genetics Homeodomain Proteins - physiology IBD Immunity - physiology Lipopolysaccharides - adverse effects Male Mice Mice, Inbred C57BL Mice, Knockout Mouse Model Prevention T-Lymphocytes - pathology
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