Stimulation of NOX2 in isolated hearts reversibly sensitizes RyR2 channels to activation by cytoplasmic calcium

Abstract The response of ryanodine receptor (RyR) channels to cytoplasmic free calcium concentration ([Ca 2 + ]) is redox sensitive. Here, we report the effects of a mild oxidative stress on cardiac RyR (RyR2) channels in Langendorff perfused rat hearts. Single RyR2 channels from control ventricles...

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Veröffentlicht in:	Journal of molecular and cellular cardiology 2014-03, Vol.68, p.38-46
Hauptverfasser:	Donoso, Paulina, Finkelstein, José Pablo, Montecinos, Luis, Said, Matilde, Sánchez, Gina, Vittone, Leticia, Bull, Ricardo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Ca2 +-induced Ca2 + release Calcium Signaling Cardiovascular Heart Ventricles - cytology Heart Ventricles - enzymology In Vitro Techniques Ion Channel Gating Ischemia/reperfusion Kinetics Membrane Glycoproteins - metabolism NADPH Oxidase 2 NADPH Oxidases - metabolism Oxidation-Reduction Oxidative Stress Preconditioning Rats Reactive Oxygen Species - metabolism Redox signaling Ryanodine Receptor Calcium Release Channel - metabolism Sarcoplasmic Reticulum - metabolism Single channel
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