Type 2 innate lymphoid cells drive CD4+ Th2 cell responses
CD4(+) T cells have long been grouped into distinct helper subsets on the basis of their cytokine-secretion profile. In recent years, several subsets of innate lymphoid cell have been described as key producers of these same Th-associated cytokines. However, the functional relationship between Th ce...
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| Veröffentlicht in: | The Journal of immunology (1950) 2014-03, Vol.192 (5), p.2442-2448 |
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| container_title | The Journal of immunology (1950) |
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| creator | Mirchandani, Ananda S Besnard, Anne-Gaelle Yip, Edwin Scott, Charlotte Bain, Calum C Cerovic, Vuk Salmond, Robert J Liew, Foo Y |
| description | CD4(+) T cells have long been grouped into distinct helper subsets on the basis of their cytokine-secretion profile. In recent years, several subsets of innate lymphoid cell have been described as key producers of these same Th-associated cytokines. However, the functional relationship between Th cells and innate lymphoid cells (ILCs) remains unclear. We show in this study that lineage-negative ST2(+)ICOS(+)CD45(+) type 2 ILCs and CD4(+) T cells can potently stimulate each other's function via distinct mechanisms. CD4(+) T cell provision of IL-2 stimulates type 2 cytokine production by type 2 ILCs. By contrast, type 2 ILCs modulate naive T cell activation in a cell contact-dependent manner, favoring Th2 while suppressing Th1 differentiation. Furthermore, a proportion of type 2 ILCs express MHC class II and can present peptide Ag in vitro. Importantly, cotransfer experiments show that type 2 ILCs also can boost CD4(+) T cell responses to Ag in vivo. |
| doi_str_mv | 10.4049/jimmunol.1300974 |
| format | Article |
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Importantly, cotransfer experiments show that type 2 ILCs also can boost CD4(+) T cell responses to Ag in vivo.</description><subject>Animals</subject><subject>Antigens, Differentiation - genetics</subject><subject>Antigens, Differentiation - immunology</subject><subject>Cell Differentiation - genetics</subject><subject>Cell Differentiation - immunology</subject><subject>Cytokines - genetics</subject><subject>Cytokines - immunology</subject><subject>Histocompatibility Antigens Class II - genetics</subject><subject>Histocompatibility Antigens Class II - immunology</subject><subject>Immunity, Innate - physiology</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Knockout</subject><subject>Th1 Cells - cytology</subject><subject>Th1 Cells - immunology</subject><subject>Th2 Cells - cytology</subject><subject>Th2 Cells - immunology</subject><issn>0022-1767</issn><issn>1550-6606</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEtLAzEUhYMotlb3riRLQabevCfupD6h4Kauw-QxdMq8TDpC_71TbV1duJxz-PgQuiYw58D1_aZqmqHt6jlhAFrxEzQlQkAmJchTNAWgNCNKqgm6SGkDABIoP0cTyrkCAXSKHla7PmCKq7YttgHXu6Zfd5XHLtR1wj5W3wEvnvgdXq3p7xPHkPquTSFdorOyqFO4OtwZ-nx5Xi3esuXH6_vicZk5DmqbeZcLpiiTSlgP1hHF81wFbQm1pRNOMpuzEUwDIdp57axiMoyonpSl5sBm6PZvt4_d1xDS1jRV2qMUbeiGZIgAkjPOcjlG4S_qYpdSDKXpY9UUcWcImL0xczRmDsbGys1hfbBN8P-FoyL2AygKZkk</recordid><startdate>20140301</startdate><enddate>20140301</enddate><creator>Mirchandani, Ananda S</creator><creator>Besnard, Anne-Gaelle</creator><creator>Yip, Edwin</creator><creator>Scott, Charlotte</creator><creator>Bain, Calum C</creator><creator>Cerovic, Vuk</creator><creator>Salmond, Robert J</creator><creator>Liew, Foo Y</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140301</creationdate><title>Type 2 innate lymphoid cells drive CD4+ Th2 cell responses</title><author>Mirchandani, Ananda S ; Besnard, Anne-Gaelle ; Yip, Edwin ; Scott, Charlotte ; Bain, Calum C ; Cerovic, Vuk ; Salmond, Robert J ; Liew, Foo Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c407t-dc853723675bd0bc174887e9b12bfc5c63b8306090119cd9cb736e006d1ff9403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Antigens, Differentiation - genetics</topic><topic>Antigens, Differentiation - immunology</topic><topic>Cell Differentiation - genetics</topic><topic>Cell Differentiation - immunology</topic><topic>Cytokines - genetics</topic><topic>Cytokines - immunology</topic><topic>Histocompatibility Antigens Class II - genetics</topic><topic>Histocompatibility Antigens Class II - immunology</topic><topic>Immunity, Innate - physiology</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Knockout</topic><topic>Th1 Cells - cytology</topic><topic>Th1 Cells - immunology</topic><topic>Th2 Cells - cytology</topic><topic>Th2 Cells - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mirchandani, Ananda S</creatorcontrib><creatorcontrib>Besnard, Anne-Gaelle</creatorcontrib><creatorcontrib>Yip, Edwin</creatorcontrib><creatorcontrib>Scott, Charlotte</creatorcontrib><creatorcontrib>Bain, Calum C</creatorcontrib><creatorcontrib>Cerovic, Vuk</creatorcontrib><creatorcontrib>Salmond, Robert J</creatorcontrib><creatorcontrib>Liew, Foo Y</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of immunology (1950)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mirchandani, Ananda S</au><au>Besnard, Anne-Gaelle</au><au>Yip, Edwin</au><au>Scott, Charlotte</au><au>Bain, Calum C</au><au>Cerovic, Vuk</au><au>Salmond, Robert J</au><au>Liew, Foo Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Type 2 innate lymphoid cells drive CD4+ Th2 cell responses</atitle><jtitle>The Journal of immunology (1950)</jtitle><addtitle>J Immunol</addtitle><date>2014-03-01</date><risdate>2014</risdate><volume>192</volume><issue>5</issue><spage>2442</spage><epage>2448</epage><pages>2442-2448</pages><issn>0022-1767</issn><eissn>1550-6606</eissn><abstract>CD4(+) T cells have long been grouped into distinct helper subsets on the basis of their cytokine-secretion profile. 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| ispartof | The Journal of immunology (1950), 2014-03, Vol.192 (5), p.2442-2448 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Animals Antigens, Differentiation - genetics Antigens, Differentiation - immunology Cell Differentiation - genetics Cell Differentiation - immunology Cytokines - genetics Cytokines - immunology Histocompatibility Antigens Class II - genetics Histocompatibility Antigens Class II - immunology Immunity, Innate - physiology Mice Mice, Inbred BALB C Mice, Knockout Th1 Cells - cytology Th1 Cells - immunology Th2 Cells - cytology Th2 Cells - immunology |
| title | Type 2 innate lymphoid cells drive CD4+ Th2 cell responses |
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