Maternal–Fetal Transmission of Hepatitis C Infection: What Is So Special About Babies?
ABSTRACTChildren with hepatitis C virus infection often differ from adults regarding the rate of viral clearance, duration of infection, and the progression to cirrhosis. In the pediatric population, vertical transmission of hepatitis C virus infection from mother to infant is the most common route...
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| Veröffentlicht in: | Journal of pediatric gastroenterology and nutrition 2014-03, Vol.58 (3), p.278-282 |
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| container_title | Journal of pediatric gastroenterology and nutrition |
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| creator | Wen, Jessica W Haber, Barbara A |
| description | ABSTRACTChildren with hepatitis C virus infection often differ from adults regarding the rate of viral clearance, duration of infection, and the progression to cirrhosis. In the pediatric population, vertical transmission of hepatitis C virus infection from mother to infant is the most common route of infection. In the present review, we explore the factors that may influence the natural history of hepatitis C virus infection in children who acquire the infection through maternal–fetal transmission. There is particular focus on how viral diversity and the infant immune system may affect viral transmission. An enhanced understanding of maternal–fetal transmission of hepatitis C virus infection has the potential to affect effective drug and vaccine development for both children and adults. |
| doi_str_mv | 10.1097/MPG.0000000000000258 |
| format | Article |
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In the pediatric population, vertical transmission of hepatitis C virus infection from mother to infant is the most common route of infection. In the present review, we explore the factors that may influence the natural history of hepatitis C virus infection in children who acquire the infection through maternal–fetal transmission. There is particular focus on how viral diversity and the infant immune system may affect viral transmission. 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An enhanced understanding of maternal–fetal transmission of hepatitis C virus infection has the potential to affect effective drug and vaccine development for both children and adults.</description><subject>Female</subject><subject>Fetus</subject><subject>Hepacivirus</subject><subject>Hepatitis C - immunology</subject><subject>Hepatitis C - transmission</subject><subject>Hepatitis C - virology</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Infectious Disease Transmission, Vertical</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Infectious - virology</subject><issn>0277-2116</issn><issn>1536-4801</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1Kw0AQxxdRbK2-gcgevaTuJtkvL1KL_YAWhVb0FibbDY2mSc1uKN58B9_QJ3GlVcSDc5nD_P4zww-hU0q6lChxMb0bdsnvCpncQ23KIh7EktB91CahEEFIKW-hI2ufPCNiRg5RK4yjmMmItdHjFJypSyg-3t4HxkGB5zWUdpVbm1clrjI8Mmtwucst7uNxmRnt_OASPyzB4bHFswrP1kbnPtlLq8bha0hzY6-O0UEGhTUnu95B94ObeX8UTG6H435vEuiIMBkoBZBqrTIumVScAxMsXQgWK5nGQoWaASwiTpiATBMOC6NCGutQcmYoz7Kog863e9d19dIY6xL_uzZFAaWpGptQRmgkBFHco_EW1XVlbW2yZF3nK6hfE0qSL6eJd5r8depjZ7sLTboyi5_Qt0QPyC2wqQov0z4XzcbUydJA4Zb_7_4EVruCeQ</recordid><startdate>201403</startdate><enddate>201403</enddate><creator>Wen, Jessica W</creator><creator>Haber, Barbara A</creator><general>by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201403</creationdate><title>Maternal–Fetal Transmission of Hepatitis C Infection: What Is So Special About Babies?</title><author>Wen, Jessica W ; Haber, Barbara A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3058-99aabcc9f6858966a575bd75498b4792c5aad36057afc06ade9214c2865e16ff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Female</topic><topic>Fetus</topic><topic>Hepacivirus</topic><topic>Hepatitis C - immunology</topic><topic>Hepatitis C - transmission</topic><topic>Hepatitis C - virology</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Infectious Disease Transmission, Vertical</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Infectious - virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wen, Jessica W</creatorcontrib><creatorcontrib>Haber, Barbara A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pediatric gastroenterology and nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wen, Jessica W</au><au>Haber, Barbara A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Maternal–Fetal Transmission of Hepatitis C Infection: What Is So Special About Babies?</atitle><jtitle>Journal of pediatric gastroenterology and nutrition</jtitle><addtitle>J Pediatr Gastroenterol Nutr</addtitle><date>2014-03</date><risdate>2014</risdate><volume>58</volume><issue>3</issue><spage>278</spage><epage>282</epage><pages>278-282</pages><issn>0277-2116</issn><eissn>1536-4801</eissn><abstract>ABSTRACTChildren with hepatitis C virus infection often differ from adults regarding the rate of viral clearance, duration of infection, and the progression to cirrhosis. 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| ispartof | Journal of pediatric gastroenterology and nutrition, 2014-03, Vol.58 (3), p.278-282 |
| issn | 0277-2116 1536-4801 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Journals@Ovid Complete |
| subjects | Female Fetus Hepacivirus Hepatitis C - immunology Hepatitis C - transmission Hepatitis C - virology Humans Infant, Newborn Infectious Disease Transmission, Vertical Pregnancy Pregnancy Complications, Infectious - virology |
| title | Maternal–Fetal Transmission of Hepatitis C Infection: What Is So Special About Babies? |
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